RXP-407 [Ligand Id: 7894] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1235767
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Angiotensin-converting enzyme in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1808] [GtoPdb: 1613] [UniProtKB: P12821]
ChEMBL Inhibition of human ACE C-terminal domain expressed in CHO cells after 90 mins by fluorescence assay B 5.12 pKi 7500 nM Ki J Med Chem (2011) 54: 5955-5980 [PMID:21780776]
ChEMBL Inhibition of human ACE N-terminal domain expressed in CHO cells after 90 mins by fluorescence assay B 8.15 pKi 7 nM Ki J Med Chem (2011) 54: 5955-5980 [PMID:21780776]
GtoPdb - - 8.15 pIC50 7 nM IC50 Biol Chem (2012) 393: 485-93 [PMID:22628311]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]