bafetinib [Ligand Id: 7906] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL206834 (Bafetinib, INNO-406, NS-187, CNS-9)
  • ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519]
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  • LYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Lyn in Human [ChEMBL: CHEMBL3905] [GtoPdb: 2060] [UniProtKB: P07948]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519]
ChEMBL Inhibition of human Abl kinase expressed in Sf9 cells B 7.59 pIC50 26 nM IC50 Bioorg. Med. Chem. Lett. (2007) 17: 2712-2717 [PMID:17376680]
GtoPdb - - 8.24 pIC50 5.8 nM IC50 Bioorg. Med. Chem. Lett. (2007) 17: 2712-7 [PMID:17376680];
Blood (2005) 106: 3948-54 [PMID:16105974]
LYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Lyn in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3905] [GtoPdb: 2060] [UniProtKB: P07948]
ChEMBL Inhibition of human Lyn kinase expressed in Sf9 cells B 7.96 pIC50 11 nM IC50 Bioorg. Med. Chem. Lett. (2007) 17: 2712-2717 [PMID:17376680]
GtoPdb - - 7.96 pIC50 11 nM IC50 Bioorg. Med. Chem. Lett. (2007) 17: 2712-7 [PMID:17376680]

ChEMBL data shown on this page come from version 25:

A.P. Bento, A. Gaulton, A. Hersey, et al. (2014). The ChEMBL bioactivity database: an update. Nucl. Acids Res. Database Issue. 42 D1083-D1090. [PMID:24214965]