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ChEMBL ligand: CHEMBL1236539 (7-Hydroxystaurosporine) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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checkpoint kinase 1/Serine/threonine-protein kinase Chk1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4630] [GtoPdb: 1987] [UniProtKB: O14757] | ||||||||
ChEMBL | Inhibition of CHK1 (unknown origin) using FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH peptide substrate incubated for 1 hr by caliper microfluidic assay | B | 8.01 | pIC50 | 9.88 | nM | IC50 | Eur J Med Chem (2015) 92: 459-470 [PMID:25594740] |
GtoPdb | - | - | 8.15 | pIC50 | 7 | nM | IC50 |
Mol Cancer Ther (2004) 3: 1221-7 [PMID:15486189]; Cancer Cell (2007) 11: 175-89 [PMID:17292828]; Cancer Res (2000) 60: 2108-12 [PMID:10786669] |
protein kinase C alpha in Human [GtoPdb: 1482] [UniProtKB: P17252] | ||||||||
GtoPdb | - | - | 7.54 | pIC50 | 29 | nM | IC50 | Mol Pharmacol (1994) 45: 1207-14 [PMID:8022414] |
protein kinase C beta in Human [GtoPdb: 1483] [UniProtKB: P05771] | ||||||||
GtoPdb | - | - | 7.54 | pIC50 | 34 | nM | IC50 | Mol Pharmacol (1994) 45: 1207-14 [PMID:8022414] |
protein kinase C gamma in Human [GtoPdb: 1484] [UniProtKB: P05129] | ||||||||
GtoPdb | - | - | 7.52 | pIC50 | 30 | nM | IC50 | Mol Pharmacol (1994) 45: 1207-14 [PMID:8022414] |
protein kinase C delta in Human [GtoPdb: 1485] [UniProtKB: Q05655] | ||||||||
GtoPdb | - | - | 6.23 | pIC50 | 590 | nM | IC50 | Mol Pharmacol (1994) 45: 1207-14 [PMID:8022414] |
protein kinase C epsilon in Human [GtoPdb: 1486] [UniProtKB: Q02156] | ||||||||
GtoPdb | - | - | 6.28 | pIC50 | 530 | nM | IC50 | Mol Pharmacol (1994) 45: 1207-14 [PMID:8022414] |
mitogen-activated protein kinase 14 in Human [GtoPdb: 1499] [UniProtKB: Q16539] | ||||||||
GtoPdb | - | - | 7.02 | pIC50 | 95 | nM | IC50 | Cancer Cell (2007) 11: 175-89 [PMID:17292828] |
3-phosphoinositide dependent protein kinase 1 in Human [GtoPdb: 1519] [UniProtKB: O15530] | ||||||||
GtoPdb | - | - | 7.48 | pIC50 | 33 | nM | IC50 | Oncogene (2002) 21: 1727-38 [PMID:11896604] |
protein kinase A in Rat [GtoPdb: 1694] | ||||||||
GtoPdb | - | - | 6 | pIC50 | 1000 | nM | IC50 | Mol Cancer Ther (2004) 3: 1221-7 [PMID:15486189] |
cyclin dependent kinase 1 in Human [GtoPdb: 1961] [UniProtKB: P06493] | ||||||||
GtoPdb | - | - | 7.3 | pIC50 | 50 | nM | IC50 | Mol Cancer Ther (2004) 3: 1221-7 [PMID:15486189] |
checkpoint kinase 2 in Human [GtoPdb: 1988] [UniProtKB: O96017] | ||||||||
GtoPdb | - | - | 5.98 | pIC50 | 1040 | nM | IC50 | Cancer Res (2000) 60: 2108-12 [PMID:10786669] |
glycogen synthase kinase 3 beta in Human [GtoPdb: 2030] [UniProtKB: P49841] | ||||||||
GtoPdb | - | - | 6.3 | pIC50 | 500 | nM | IC50 | Mol Cancer Ther (2004) 3: 1221-7 [PMID:15486189] |
LCK proto-oncogene, Src family tyrosine kinase in Human [GtoPdb: 2053] [UniProtKB: P06239] | ||||||||
GtoPdb | - | - | 7.3 | pIC50 | 50 | nM | IC50 | Mol Cancer Ther (2004) 3: 1221-7 [PMID:15486189] |
microtubule affinity regulating kinase 1 in Human [GtoPdb: 2097] [UniProtKB: Q9P0L2] | ||||||||
GtoPdb | - | - | 7.57 | pIC50 | 27 | nM | IC50 | Cancer Res (2000) 60: 2108-12 [PMID:10786669] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]