GNE-9605 [Ligand Id: 7919] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL3122117
  • leucine rich repeat kinase 2/Leucine-rich repeat serine/threonine-protein kinase 2 in Human [ChEMBL: CHEMBL1075104] [GtoPdb: 2059] [UniProtKB: Q5S007]
  • This target only has 1 pki data point
  • 8.7
1 CHEMBL3122117_lig_chart_1 Leucine-rich repeat serine/threonine-protein kinase 2 Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
leucine rich repeat kinase 2/Leucine-rich repeat serine/threonine-protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075104] [GtoPdb: 2059] [UniProtKB: Q5S007]
ChEMBL Inhibition of LRRK2 (unknown origin) B 8.7 pKi 2 nM Ki J. Med. Chem. (2014) 57: 921-936 [PMID:24354345]
GtoPdb - - 7.72 pIC50 19 nM IC50 J Med Chem (2014) 57: 921-36 [PMID:24354345]
ChEMBL Inhibition of LRRK2 (unknown origin) phosphorylation by cell-based assay B 7.73 pIC50 18.7 nM IC50 J. Med. Chem. (2014) 57: 921-936 [PMID:24354345]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]