binimetinib [Ligand Id: 7921] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL3187723 (MEK162, MEK-162, Mektovi, Binimetinib, ARRY-162, NVP-MEK162, Mek-162, ARRY 438162, ARRY-438162)
  • mitogen-activated protein kinase kinase 1 in Human [GtoPdb: 2062] [UniProtKB: Q02750]
  • This target only has 0 pki data point
  • 0
1 CHEMBL3187723_lig_chart_1 mitogen-activated protein kinase kinase 1 Human
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  • mitogen-activated protein kinase kinase 2 in Human [GtoPdb: 2063] [UniProtKB: P36507]
  • This target only has 0 pki data point
  • 0
2 CHEMBL3187723_lig_chart_2 mitogen-activated protein kinase kinase 2 Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
mitogen-activated protein kinase kinase 1 in Human [GtoPdb: 2062] [UniProtKB: Q02750]
GtoPdb - - 7.92 pIC50 12 nM IC50 American College of Rheumatology 2006 Annual Scientific Meeting (2006) : Abstract 794
mitogen-activated protein kinase kinase 2 in Human [GtoPdb: 2063] [UniProtKB: P36507]
GtoPdb - - 7.92 pIC50 12 nM IC50 American College of Rheumatology 2006 Annual Scientific Meeting (2006) : Abstract 794

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]