XL388 [Ligand Id: 7973] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2333365
  • 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3/6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 in Human [ChEMBL: CHEMBL2331053] [GtoPdb: 2937] [UniProtKB: Q16875]
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  • ALK receptor tyrosine kinase/ALK tyrosine kinase receptor in Human [ChEMBL: CHEMBL4247] [GtoPdb: 1839] [UniProtKB: Q9UM73]
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  • protein kinase AMP-activated non-catalytic subunit beta 1/AMP-activated protein kinase, beta-1 subunit in Human [ChEMBL: CHEMBL3847] [GtoPdb: 1543] [UniProtKB: Q9Y478]
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  • BR serine/threonine kinase 1/BR serine/threonine-protein kinase 1 in Human [ChEMBL: CHEMBL5650] [GtoPdb: 1946] [UniProtKB: Q8TDC3]
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  • calcium/calmodulin dependent protein kinase I/CaM kinase I alpha in Human [ChEMBL: CHEMBL2493] [GtoPdb: 1952] [UniProtKB: Q14012]
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  • calcium/calmodulin dependent protein kinase IV/CaM kinase IV in Human [ChEMBL: CHEMBL2494] [GtoPdb: 1955] [UniProtKB: Q16566]
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  • casein kinase 1 delta/Casein kinase I delta in Human [ChEMBL: CHEMBL2828] [GtoPdb: 1997] [UniProtKB: P48730]
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  • casein kinase 2, alpha prime polypeptide subunit/casein kinase 2, beta polypeptide subunit/casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II in Human [ChEMBL: CHEMBL2095191] [GtoPdb: 155015511549] [UniProtKB: P19784P67870P68400]
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  • cell division cycle 7/Cell division cycle 7-related protein kinase in Human [ChEMBL: CHEMBL5443] [GtoPdb: 1960] [UniProtKB: O00311]
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  • Protein kinase G (PKG) 1/cGMP-dependent protein kinase 1 beta in Human [ChEMBL: CHEMBL4273] [GtoPdb: 1492] [UniProtKB: Q13976]
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  • mitogen-activated protein kinase 8/c-Jun N-terminal kinase 1 in Human [ChEMBL: CHEMBL2276] [GtoPdb: 1496] [UniProtKB: P45983]
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  • mitogen-activated protein kinase 10/c-Jun N-terminal kinase 3 in Human [ChEMBL: CHEMBL2637] [GtoPdb: 1498] [UniProtKB: P53779]
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  • cyclin dependent kinase 5/Cyclin-dependent kinase 5/CDK5 activator 1 in Human [ChEMBL: CHEMBL1907600] [GtoPdb: 1977] [UniProtKB: Q00535Q15078]
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  • death associated protein kinase 2/Death-associated protein kinase 2 in Human [ChEMBL: CHEMBL3123] [GtoPdb: 2003] [UniProtKB: Q9UIK4]
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  • death associated protein kinase 3/Death-associated protein kinase 3 in Human [ChEMBL: CHEMBL2468] [GtoPdb: 2004] [UniProtKB: O43293]
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  • discoidin domain receptor tyrosine kinase 2/Discoidin domain-containing receptor 2 in Human [ChEMBL: CHEMBL5122] [GtoPdb: 1844] [UniProtKB: Q16832]
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  • protein kinase, DNA-activated, catalytic subunit/DNA-dependent protein kinase in Human [ChEMBL: CHEMBL3142] [GtoPdb: 2800] [UniProtKB: P78527]
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  • mitogen-activated protein kinase kinase 1/Dual specificity mitogen-activated protein kinase kinase 1 in Human [ChEMBL: CHEMBL3587] [GtoPdb: 2062] [UniProtKB: Q02750]
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  • mitogen-activated protein kinase kinase 4/Dual specificity mitogen-activated protein kinase kinase 4 in Human [ChEMBL: CHEMBL2897] [GtoPdb: 2065] [UniProtKB: P45985]
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  • mitogen-activated protein kinase kinase 6/Dual specificity mitogen-activated protein kinase kinase 6 in Human [ChEMBL: CHEMBL2171] [GtoPdb: 2067] [UniProtKB: P52564]
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  • mitogen-activated protein kinase kinase 7/Dual specificity mitogen-activated protein kinase kinase 7 in Human [ChEMBL: CHEMBL3530] [GtoPdb: 2068] [UniProtKB: O14733]
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  • CDC like kinase 2/Dual specificity protein kinase CLK2 in Human [ChEMBL: CHEMBL4225] [GtoPdb: 1991] [UniProtKB: P49760]
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  • dual specificity tyrosine phosphorylation regulated kinase 2/Dual-specificity tyrosine-phosphorylation regulated kinase 2 in Human [ChEMBL: CHEMBL4376] [GtoPdb: 2011] [UniProtKB: Q92630]
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  • EPH receptor A2/Ephrin type-A receptor 2 in Human [ChEMBL: CHEMBL2068] [GtoPdb: 1822] [UniProtKB: P29317]
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  • EPH receptor B1/Ephrin type-B receptor 1 in Human [ChEMBL: CHEMBL5072] [GtoPdb: 1830] [UniProtKB: P54762]
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  • epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
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  • fibroblast growth factor receptor 1/Fibroblast growth factor receptor 1 in Human [ChEMBL: CHEMBL3650] [GtoPdb: 1808] [UniProtKB: P11362]
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  • fibroblast growth factor receptor 2/Fibroblast growth factor receptor 2 in Human [ChEMBL: CHEMBL4142] [GtoPdb: 1809] [UniProtKB: P21802]
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  • fibroblast growth factor receptor 3/Fibroblast growth factor receptor 3 in Human [ChEMBL: CHEMBL2742] [GtoPdb: 1810] [UniProtKB: P22607]
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  • fibroblast growth factor receptor 4/Fibroblast growth factor receptor 4 in Human [ChEMBL: CHEMBL3973] [GtoPdb: 1811] [UniProtKB: P22455]
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  • protein tyrosine kinase 2/Focal adhesion kinase 1 in Human [ChEMBL: CHEMBL2695] [GtoPdb: 2180] [UniProtKB: Q05397]
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  • glycogen synthase kinase 3 alpha/Glycogen synthase kinase-3 alpha in Human [ChEMBL: CHEMBL2850] [GtoPdb: 2029] [UniProtKB: P49840]
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  • glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841]
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  • G protein-coupled receptor kinase 5 in Human [ChEMBL: CHEMBL5678] [GtoPdb: 1469] [UniProtKB: P34947]
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  • heat shock protein 90 alpha family class B member 1/Heat shock protein HSP 90-beta in Human [ChEMBL: CHEMBL4303] [GtoPdb: 2907] [UniProtKB: P08238]
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  • MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581]
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  • homeodomain interacting protein kinase 2/Homeodomain-interacting protein kinase 2 in Human [ChEMBL: CHEMBL4576] [GtoPdb: 2034] [UniProtKB: Q9H2X6]
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  • component of inhibitor of nuclear factor kappa B kinase complex/Inhibitor of nuclear factor kappa B kinase alpha subunit in Human [ChEMBL: CHEMBL3476] [GtoPdb: 1989] [UniProtKB: O15111]
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  • inhibitor of nuclear factor kappa B kinase subunit beta/Inhibitor of nuclear factor kappa B kinase beta subunit in Human [ChEMBL: CHEMBL1991] [GtoPdb: 2039] [UniProtKB: O14920]
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  • Insulin-like growth factor I receptor in Human [ChEMBL: CHEMBL1957] [GtoPdb: 1801] [UniProtKB: P08069]
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  • interleukin 1 receptor associated kinase 1/Interleukin-1 receptor-associated kinase 1 in Human [ChEMBL: CHEMBL3357] [GtoPdb: 2042] [UniProtKB: P51617]
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  • MAPK activated protein kinase 2/MAP kinase-activated protein kinase 2 in Human [ChEMBL: CHEMBL2208] [GtoPdb: 2094] [UniProtKB: P49137]
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  • MAPK activated protein kinase 3/MAP kinase-activated protein kinase 3 in Human [ChEMBL: CHEMBL4670] [GtoPdb: 2095] [UniProtKB: Q16644]
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  • MAPK activated protein kinase 5/MAP kinase-activated protein kinase 5 in Human [ChEMBL: CHEMBL3094] [GtoPdb: 2096] [UniProtKB: Q8IW41]
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  • mitogen-activated protein kinase 1/MAP kinase ERK2 in Human [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482]
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  • MAPK interacting serine/threonine kinase 2/MAP kinase signal-integrating kinase 2 in Human [ChEMBL: CHEMBL4204] [GtoPdb: 2105] [UniProtKB: Q9HBH9]
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  • misshapen like kinase 1/Misshapen-like kinase 1 in Human [ChEMBL: CHEMBL5518] [GtoPdb: 2103] [UniProtKB: Q8N4C8]
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  • mitogen-activated protein kinase kinase kinase 5/Mitogen-activated protein kinase kinase kinase 5 in Human [ChEMBL: CHEMBL5285] [GtoPdb: 2080] [UniProtKB: Q99683]
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  • mitogen-activated protein kinase kinase kinase 9/Mitogen-activated protein kinase kinase kinase 9 in Human [ChEMBL: CHEMBL2872] [GtoPdb: 2084] [UniProtKB: P80192]
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  • mitogen-activated protein kinase kinase kinase kinase 2/Mitogen-activated protein kinase kinase kinase kinase 2 in Human [ChEMBL: CHEMBL5330] [GtoPdb: 2086] [UniProtKB: Q12851]
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  • muscle associated receptor tyrosine kinase/Muscle, skeletal receptor tyrosine protein kinase in Human [ChEMBL: CHEMBL5684] [GtoPdb: 1847] [UniProtKB: O15146]
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  • Testicular receptor 4/Nuclear receptor subfamily 2 group C member 2 in Human [ChEMBL: CHEMBL5716] [GtoPdb: 614] [UniProtKB: P49116]
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  • PAS domain containing serine/threonine kinase/PAS domain-containing serine/threonine-protein kinase in Human [ChEMBL: CHEMBL6054] [GtoPdb: 2139] [UniProtKB: Q96RG2]
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  • phosphatidylinositol 3-kinase catalytic subunit type 3/Phosphatidylinositol 3-kinase catalytic subunit type 3 in Human [ChEMBL: CHEMBL1075165] [GtoPdb: 2152] [UniProtKB: Q8NEB9]
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  • phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/PI3-kinase p110-alpha subunit in Human [ChEMBL: CHEMBL4005] [GtoPdb: 2153] [UniProtKB: P42336]
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  • phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta/PI3-kinase p110-beta subunit in Human [ChEMBL: CHEMBL3145] [GtoPdb: 2154] [UniProtKB: P42338]
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  • phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta/PI3-kinase p110-delta subunit in Human [ChEMBL: CHEMBL3130] [GtoPdb: 2155] [UniProtKB: O00329]
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  • phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma/PI3-kinase p110-gamma subunit in Human [ChEMBL: CHEMBL3267] [GtoPdb: 2156] [UniProtKB: P48736]
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  • platelet derived growth factor receptor beta/Platelet-derived growth factor receptor beta in Human [ChEMBL: CHEMBL1913] [GtoPdb: 1804] [UniProtKB: P09619]
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  • protein kinase C alpha/Protein kinase C alpha in Human [ChEMBL: CHEMBL299] [GtoPdb: 1482] [UniProtKB: P17252]
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  • protein kinase C beta/Protein kinase C beta in Human [ChEMBL: CHEMBL3045] [GtoPdb: 1483] [UniProtKB: P05771]
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  • protein kinase C delta/Protein kinase C delta in Human [ChEMBL: CHEMBL2996] [GtoPdb: 1485] [UniProtKB: Q05655]
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  • protein kinase C epsilon/Protein kinase C epsilon in Human [ChEMBL: CHEMBL3582] [GtoPdb: 1486] [UniProtKB: Q02156]
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  • protein kinase C eta/Protein kinase C eta in Human [ChEMBL: CHEMBL3616] [GtoPdb: 1487] [UniProtKB: P24723]
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  • protein kinase C gamma/Protein kinase C gamma in Human [ChEMBL: CHEMBL2938] [GtoPdb: 1484] [UniProtKB: P05129]
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  • protein kinase C iota/Protein kinase C iota in Human [ChEMBL: CHEMBL2598] [GtoPdb: 1490] [UniProtKB: P41743]
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  • protein kinase D1/Protein kinase C mu in Human [ChEMBL: CHEMBL3863] [GtoPdb: 1489] [UniProtKB: Q15139]
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  • protein kinase C theta/Protein kinase C theta in Human [ChEMBL: CHEMBL3920] [GtoPdb: 1488] [UniProtKB: Q04759]
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  • protein kinase C zeta/Protein kinase C zeta in Human [ChEMBL: CHEMBL3438] [GtoPdb: 1491] [UniProtKB: Q05513]
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  • protein kinase N2/Protein kinase N2 in Human [ChEMBL: CHEMBL3032] [GtoPdb: 1521] [UniProtKB: Q16513]
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  • protein tyrosine kinase 2 beta/Protein tyrosine kinase 2 beta in Human [ChEMBL: CHEMBL5469] [GtoPdb: 2181] [UniProtKB: Q14289]
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  • MER proto-oncogene, tyrosine kinase/Proto-oncogene tyrosine-protein kinase MER in Human [ChEMBL: CHEMBL5331] [GtoPdb: 1837] [UniProtKB: Q12866]
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  • c-ros oncogene 1, receptor tyrosine kinase/Proto-oncogene tyrosine-protein kinase ROS in Human [ChEMBL: CHEMBL5568] [GtoPdb: 1840] [UniProtKB: P08922]
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  • pyruvate dehydrogenase kinase 1/Pyruvate dehydrogenase kinase isoform 1 in Human [ChEMBL: CHEMBL4766] [GtoPdb: 2915] [UniProtKB: Q15118]
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  • erb-b2 receptor tyrosine kinase 2/Receptor protein-tyrosine kinase erbB-2 in Human [ChEMBL: CHEMBL1824] [GtoPdb: 2019] [UniProtKB: P04626]
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  • Rho associated coiled-coil containing protein kinase 1/Rho-associated protein kinase 1 in Human [ChEMBL: CHEMBL3231] [GtoPdb: 1503] [UniProtKB: Q13464]
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  • Rho associated coiled-coil containing protein kinase 2/Rho-associated protein kinase 2 in Human [ChEMBL: CHEMBL2973] [GtoPdb: 1504] [UniProtKB: O75116]
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  • ribosomal protein S6 kinase B1/Ribosomal protein S6 kinase 1 in Human [ChEMBL: CHEMBL4501] [GtoPdb: 1525] [UniProtKB: P23443]
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  • ribosomal protein S6 kinase A1/Ribosomal protein S6 kinase alpha 1 in Human [ChEMBL: CHEMBL2553] [GtoPdb: 1527] [UniProtKB: Q15418]
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  • ribosomal protein S6 kinase A2/Ribosomal protein S6 kinase alpha 2 in Human [ChEMBL: CHEMBL3906] [GtoPdb: 1529] [UniProtKB: Q15349]
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  • ribosomal protein S6 kinase A3/Ribosomal protein S6 kinase alpha 3 in Human [ChEMBL: CHEMBL2345] [GtoPdb: 1528] [UniProtKB: P51812]
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  • ribosomal protein S6 kinase A5/Ribosomal protein S6 kinase alpha 5 in Human [ChEMBL: CHEMBL4237] [GtoPdb: 1523] [UniProtKB: O75582]
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  • ribosomal protein S6 kinase A6/Ribosomal protein S6 kinase alpha 6 in Human [ChEMBL: CHEMBL4924] [GtoPdb: 1530] [UniProtKB: Q9UK32]
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  • serine/threonine kinase 10/Serine/threonine-protein kinase 10 in Human [ChEMBL: CHEMBL3981] [GtoPdb: 2211] [UniProtKB: O94804]
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  • serine/threonine kinase 11/Serine/threonine-protein kinase 11 in Human [ChEMBL: CHEMBL5606] [GtoPdb: 2212] [UniProtKB: Q15831]
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  • serine/threonine kinase 33/Serine/threonine-protein kinase 33 in Human [ChEMBL: CHEMBL6005] [GtoPdb: 2221] [UniProtKB: Q9BYT3]
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  • AKT serine/threonine kinase 1/Serine/threonine-protein kinase AKT in Human [ChEMBL: CHEMBL4282] [GtoPdb: 1479] [UniProtKB: P31749]
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  • AKT serine/threonine kinase 2/Serine/threonine-protein kinase AKT2 in Human [ChEMBL: CHEMBL2431] [GtoPdb: 1480] [UniProtKB: P31751]
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  • AKT serine/threonine kinase 3/Serine/threonine-protein kinase AKT3 in Human [ChEMBL: CHEMBL4816] [GtoPdb: 2286] [UniProtKB: Q9Y243]
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  • aurora kinase A/Serine/threonine-protein kinase Aurora-A in Human [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965]
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  • checkpoint kinase 1/Serine/threonine-protein kinase Chk1 in Human [ChEMBL: CHEMBL4630] [GtoPdb: 1987] [UniProtKB: O14757]
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  • checkpoint kinase 2/Serine/threonine-protein kinase Chk2 in Human [ChEMBL: CHEMBL2527] [GtoPdb: 1988] [UniProtKB: O96017]
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  • protein kinase D2/Serine/threonine-protein kinase D2 in Human [ChEMBL: CHEMBL4900] [GtoPdb: 2173] [UniProtKB: Q9BZL6]
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  • histone H3 associated protein kinase/Serine/threonine-protein kinase haspin in Human [ChEMBL: CHEMBL1075163] [GtoPdb: 2028] [UniProtKB: Q8TF76]
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  • microtubule affinity regulating kinase 1/Serine/threonine-protein kinase MARK1 in Human [ChEMBL: CHEMBL5940] [GtoPdb: 2097] [UniProtKB: Q9P0L2]
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  • serine/threonine kinase 4/Serine/threonine-protein kinase MST1 in Human [ChEMBL: CHEMBL4598] [GtoPdb: 2225] [UniProtKB: Q13043]
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  • NIMA related kinase 2/Serine/threonine-protein kinase NEK2 in Human [ChEMBL: CHEMBL3835] [GtoPdb: 2117] [UniProtKB: P51955]
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  • NIMA related kinase 7/Serine/threonine-protein kinase NEK7 in Human [ChEMBL: CHEMBL4849] [GtoPdb: 2122] [UniProtKB: Q8TDX7]
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  • nemo like kinase/Serine/threonine protein kinase NLK in Human [ChEMBL: CHEMBL5364] [GtoPdb: 2125] [UniProtKB: Q9UBE8]
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  • p21 (RAC1) activated kinase 3/Serine/threonine-protein kinase PAK 3 in Human [ChEMBL: CHEMBL2999] [GtoPdb: 2135] [UniProtKB: O75914]
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  • p21 (RAC1) activated kinase 6/Serine/threonine-protein kinase PAK6 in Human [ChEMBL: CHEMBL4311] [GtoPdb: 2137] [UniProtKB: Q9NQU5]
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  • Pim-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM1 in Human [ChEMBL: CHEMBL2147] [GtoPdb: 2158] [UniProtKB: P11309]
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  • polo like kinase 1/Serine/threonine-protein kinase PLK1 in Human [ChEMBL: CHEMBL3024] [GtoPdb: 2168] [UniProtKB: P53350]
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  • polo like kinase 3/Serine/threonine-protein kinase PLK3 in Human [ChEMBL: CHEMBL4897] [GtoPdb: 2170] [UniProtKB: Q9H4B4]
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  • Raf-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase RAF in Human [ChEMBL: CHEMBL1906] [GtoPdb: 2184] [UniProtKB: P04049]
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  • receptor interacting serine/threonine kinase 2/Serine/threonine-protein kinase RIPK2 in Human [ChEMBL: CHEMBL5014] [GtoPdb: 2190] [UniProtKB: O43353]
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  • serum/glucocorticoid regulated kinase 1/Serine/threonine-protein kinase Sgk1 in Human [ChEMBL: CHEMBL2343] [GtoPdb: 1534] [UniProtKB: O00141]
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  • serum/glucocorticoid regulated kinase 2/Serine/threonine-protein kinase Sgk2 in Human [ChEMBL: CHEMBL5794] [GtoPdb: 1535] [UniProtKB: Q9HBY8]
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  • serum/glucocorticoid regulated kinase family member 3/Serine/threonine-protein kinase Sgk3 in Human [ChEMBL: CHEMBL6186] [GtoPdb: 1536] [UniProtKB: Q96BR1]
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  • SRSF protein kinase 3/Serine/threonine-protein kinase SRPK3 in Human [ChEMBL: CHEMBL5415] [GtoPdb: 2210] [UniProtKB: Q9UPE1]
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  • TAO kinase 1/Serine/threonine-protein kinase TAO1 in Human [ChEMBL: CHEMBL5261] [GtoPdb: 2233] [UniProtKB: Q7L7X3]
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  • TANK binding kinase 1/Serine/threonine-protein kinase TBK1 in Human [ChEMBL: CHEMBL5408] [GtoPdb: 2237] [UniProtKB: Q9UHD2]
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  • unc-51 like autophagy activating kinase 2/Serine/threonine-protein kinase ULK2 in Human [ChEMBL: CHEMBL5435] [GtoPdb: 2272] [UniProtKB: Q8IYT8]
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  • VRK serine/threonine kinase 2/Serine/threonine-protein kinase VRK2 in Human [ChEMBL: CHEMBL1649059] [GtoPdb: 2276] [UniProtKB: Q86Y07]
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  • WNK lysine deficient protein kinase 2/Serine/threonine-protein kinase WNK2 in Human [ChEMBL: CHEMBL5639] [GtoPdb: 2281] [UniProtKB: Q9Y3S1]
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  • KIT proto-oncogene, receptor tyrosine kinase/Stem cell growth factor receptor in Human [ChEMBL: CHEMBL1936] [GtoPdb: 1805] [UniProtKB: P10721]
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  • testis specific serine kinase 1B/Testis-specific serine/threonine-protein kinase 1 in Human [ChEMBL: CHEMBL6003] [GtoPdb: 2257] [UniProtKB: Q9BXA7]
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  • tyrosine kinase non receptor 2/Tyrosine kinase non-receptor protein 2 in Human [ChEMBL: CHEMBL4599] [GtoPdb: 2246] [UniProtKB: Q07912]
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  • ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519]
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  • ABL proto-oncogene 2, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL2 in Human [ChEMBL: CHEMBL4014] [GtoPdb: 1924] [UniProtKB: P42684]
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  • BLK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase BLK in Human [ChEMBL: CHEMBL2250] [GtoPdb: 1940] [UniProtKB: P51451]
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  • protein tyrosine kinase 6/Tyrosine-protein kinase BRK in Human [ChEMBL: CHEMBL4601] [GtoPdb: 2182] [UniProtKB: Q13882]
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  • C-terminal Src kinase/Tyrosine-protein kinase CSK in Human [ChEMBL: CHEMBL2634] [GtoPdb: 1994] [UniProtKB: P41240]
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  • FES proto-oncogene, tyrosine kinase/Tyrosine-protein kinase FES in Human [ChEMBL: CHEMBL5455] [GtoPdb: 2023] [UniProtKB: P07332]
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  • HCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase HCK in Human [ChEMBL: CHEMBL3234] [GtoPdb: 2032] [UniProtKB: P08631]
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  • IL2 inducible T cell kinase/Tyrosine-protein kinase ITK/TSK in Human [ChEMBL: CHEMBL2959] [GtoPdb: 2046] [UniProtKB: Q08881]
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  • Janus kinase 2/Tyrosine-protein kinase JAK2 in Human [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674]
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  • LYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Lyn in Human [ChEMBL: CHEMBL3905] [GtoPdb: 2060] [UniProtKB: P07948]
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  • fms related receptor tyrosine kinase 3/Tyrosine-protein kinase receptor FLT3 in Human [ChEMBL: CHEMBL1974] [GtoPdb: 1807] [UniProtKB: P36888]
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  • ret proto-oncogene/Tyrosine-protein kinase receptor RET in Human [ChEMBL: CHEMBL2041] [GtoPdb: 2185] [UniProtKB: P07949]
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  • TYRO3 protein tyrosine kinase/Tyrosine-protein kinase receptor TYRO3 in Human [ChEMBL: CHEMBL5314] [GtoPdb: 1836] [UniProtKB: Q06418]
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  • AXL receptor tyrosine kinase/Tyrosine-protein kinase receptor UFO in Human [ChEMBL: CHEMBL4895] [GtoPdb: 1835] [UniProtKB: P30530]
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  • SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931]
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  • YES proto-oncogene 1, Src family tyrosine kinase/Tyrosine-protein kinase YES in Human [ChEMBL: CHEMBL2073] [GtoPdb: 2284] [UniProtKB: P07947]
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  • zeta chain of T cell receptor associated protein kinase 70/Tyrosine-protein kinase ZAP-70 in Human [ChEMBL: CHEMBL2803] [GtoPdb: 2285] [UniProtKB: P43403]
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  • fms related receptor tyrosine kinase 1/Vascular endothelial growth factor receptor 1 in Human [ChEMBL: CHEMBL1868] [GtoPdb: 1812] [UniProtKB: P17948]
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  • kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968]
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  • mechanistic target of rapamycin kinase in Human [GtoPdb: 2109] [UniProtKB: P42345]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3/6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2331053] [GtoPdb: 2937] [UniProtKB: Q16875]
ChEMBL Inhibition of IPFK2 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
ALK receptor tyrosine kinase/ALK tyrosine kinase receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4247] [GtoPdb: 1839] [UniProtKB: Q9UM73]
ChEMBL Inhibition of ALK (unknown origin) B 5.46 pIC50 >3500 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
protein kinase AMP-activated non-catalytic subunit beta 1/AMP-activated protein kinase, beta-1 subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3847] [GtoPdb: 1543] [UniProtKB: Q9Y478]
ChEMBL Inhibition of AMPK (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
BR serine/threonine kinase 1/BR serine/threonine-protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5650] [GtoPdb: 1946] [UniProtKB: Q8TDC3]
ChEMBL Inhibition of BRSK1 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
calcium/calmodulin dependent protein kinase I/CaM kinase I alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2493] [GtoPdb: 1952] [UniProtKB: Q14012]
ChEMBL Inhibition of CAMK1 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
calcium/calmodulin dependent protein kinase IV/CaM kinase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2494] [GtoPdb: 1955] [UniProtKB: Q16566]
ChEMBL Inhibition of CAMK4 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
casein kinase 1 delta/Casein kinase I delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2828] [GtoPdb: 1997] [UniProtKB: P48730]
ChEMBL Inhibition of CK1delta (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
casein kinase 2, alpha prime polypeptide subunit/casein kinase 2, beta polypeptide subunit/casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2095191] [GtoPdb: 155015511549] [UniProtKB: P19784P67870P68400]
ChEMBL Inhibition of CK2 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
cyclin dependent kinase 3/CDK3/cyclin E in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2111444] [GtoPdb: 1975] [UniProtKB: O96020P24864Q00526]
ChEMBL Inhibition of CDK3/Cyclin E (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
cell division cycle 7/Cell division cycle 7-related protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5443] [GtoPdb: 1960] [UniProtKB: O00311]
ChEMBL Inhibition of CDC7 (unknown origin) B 5.46 pIC50 >3500 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
Protein kinase G (PKG) 1/cGMP-dependent protein kinase 1 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4273] [GtoPdb: 1492] [UniProtKB: Q13976]
ChEMBL Inhibition of PKG1beta (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
mitogen-activated protein kinase 8/c-Jun N-terminal kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2276] [GtoPdb: 1496] [UniProtKB: P45983]
ChEMBL Inhibition of JNK1alpha2 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
ChEMBL Inhibition of JNK1alpha1 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
mitogen-activated protein kinase 10/c-Jun N-terminal kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2637] [GtoPdb: 1498] [UniProtKB: P53779]
ChEMBL Inhibition of JNK3 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
cyclin dependent kinase 5/Cyclin-dependent kinase 5/CDK5 activator 1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907600] [GtoPdb: 1977] [UniProtKB: Q00535Q15078]
ChEMBL Inhibition of CDK5/P25 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
death associated protein kinase 2/Death-associated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3123] [GtoPdb: 2003] [UniProtKB: Q9UIK4]
ChEMBL Inhibition of DAPK2 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
death associated protein kinase 3/Death-associated protein kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2468] [GtoPdb: 2004] [UniProtKB: O43293]
ChEMBL Inhibition of ZIPK (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
discoidin domain receptor tyrosine kinase 2/Discoidin domain-containing receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5122] [GtoPdb: 1844] [UniProtKB: Q16832]
ChEMBL Inhibition of DDR2 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
protein kinase, DNA-activated, catalytic subunit/DNA-dependent protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3142] [GtoPdb: 2800] [UniProtKB: P78527]
ChEMBL Inhibition of DNA-PK (unknown origin) B 5.05 pIC50 8831 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
mitogen-activated protein kinase kinase 1/Dual specificity mitogen-activated protein kinase kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3587] [GtoPdb: 2062] [UniProtKB: Q02750]
ChEMBL Inhibition of MEK1 (unknown origin) B 5.46 pIC50 >3500 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
mitogen-activated protein kinase kinase 4/Dual specificity mitogen-activated protein kinase kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2897] [GtoPdb: 2065] [UniProtKB: P45985]
ChEMBL Inhibition of MKK4 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
mitogen-activated protein kinase kinase 6/Dual specificity mitogen-activated protein kinase kinase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2171] [GtoPdb: 2067] [UniProtKB: P52564]
ChEMBL Inhibition of MKK6 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
mitogen-activated protein kinase kinase 7/Dual specificity mitogen-activated protein kinase kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3530] [GtoPdb: 2068] [UniProtKB: O14733]
ChEMBL Inhibition of MKK7beta (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
CDC like kinase 2/Dual specificity protein kinase CLK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4225] [GtoPdb: 1991] [UniProtKB: P49760]
ChEMBL Inhibition of CLK2 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
dual specificity tyrosine phosphorylation regulated kinase 2/Dual-specificity tyrosine-phosphorylation regulated kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4376] [GtoPdb: 2011] [UniProtKB: Q92630]
ChEMBL Inhibition of DYRK2 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
EPH receptor A2/Ephrin type-A receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2068] [GtoPdb: 1822] [UniProtKB: P29317]
ChEMBL Inhibition of EPHA2 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
EPH receptor B1/Ephrin type-B receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5072] [GtoPdb: 1830] [UniProtKB: P54762]
ChEMBL Inhibition of EPHB1 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
ChEMBL Inhibition of EGFR (unknown origin) B 5.46 pIC50 >3500 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
fibroblast growth factor receptor 1/Fibroblast growth factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3650] [GtoPdb: 1808] [UniProtKB: P11362]
ChEMBL Inhibition of FGFR1 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
fibroblast growth factor receptor 2/Fibroblast growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4142] [GtoPdb: 1809] [UniProtKB: P21802]
ChEMBL Inhibition of FGFR2 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
fibroblast growth factor receptor 3/Fibroblast growth factor receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2742] [GtoPdb: 1810] [UniProtKB: P22607]
ChEMBL Inhibition of FGFR3 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
fibroblast growth factor receptor 4/Fibroblast growth factor receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3973] [GtoPdb: 1811] [UniProtKB: P22455]
ChEMBL Inhibition of FGFR4 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
protein tyrosine kinase 2/Focal adhesion kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2695] [GtoPdb: 2180] [UniProtKB: Q05397]
ChEMBL Inhibition of FAK (unknown origin) B 5.46 pIC50 >3500 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
glycogen synthase kinase 3 alpha/Glycogen synthase kinase-3 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2850] [GtoPdb: 2029] [UniProtKB: P49840]
ChEMBL Inhibition of GSK3alpha (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841]
ChEMBL Inhibition of GSK3beta (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
G protein-coupled receptor kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5678] [GtoPdb: 1469] [UniProtKB: P34947]
ChEMBL Inhibition of GRK5 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
heat shock protein 90 alpha family class B member 1/Heat shock protein HSP 90-beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4303] [GtoPdb: 2907] [UniProtKB: P08238]
ChEMBL Inhibition of HSP90 (unknown origin) B 5.46 pIC50 >3500 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581]
ChEMBL Inhibition of MET (unknown origin) B 5.46 pIC50 >3500 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
homeodomain interacting protein kinase 2/Homeodomain-interacting protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4576] [GtoPdb: 2034] [UniProtKB: Q9H2X6]
ChEMBL Inhibition of HIPK2 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
component of inhibitor of nuclear factor kappa B kinase complex/Inhibitor of nuclear factor kappa B kinase alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3476] [GtoPdb: 1989] [UniProtKB: O15111]
ChEMBL Inhibition of IKKalpha (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
inhibitor of nuclear factor kappa B kinase subunit beta/Inhibitor of nuclear factor kappa B kinase beta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1991] [GtoPdb: 2039] [UniProtKB: O14920]
ChEMBL Inhibition of IKKbeta (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
Insulin-like growth factor I receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1957] [GtoPdb: 1801] [UniProtKB: P08069]
ChEMBL Inhibition of IGF1R (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
interleukin 1 receptor associated kinase 1/Interleukin-1 receptor-associated kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3357] [GtoPdb: 2042] [UniProtKB: P51617]
ChEMBL Inhibition of IRAK1 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
LIM domain kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3836] [GtoPdb: 2054] [UniProtKB: P53667]
ChEMBL Inhibition of LIMK1 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
MAPK activated protein kinase 2/MAP kinase-activated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2208] [GtoPdb: 2094] [UniProtKB: P49137]
ChEMBL Inhibition of MAPK2 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
MAPK activated protein kinase 3/MAP kinase-activated protein kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4670] [GtoPdb: 2095] [UniProtKB: Q16644]
ChEMBL Inhibition of MAPKAPK3 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
MAPK activated protein kinase 5/MAP kinase-activated protein kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3094] [GtoPdb: 2096] [UniProtKB: Q8IW41]
ChEMBL Inhibition of PRAK (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
mitogen-activated protein kinase 1/MAP kinase ERK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482]
ChEMBL Inhibition of MAPK1 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
MAPK interacting serine/threonine kinase 2/MAP kinase signal-integrating kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4204] [GtoPdb: 2105] [UniProtKB: Q9HBH9]
ChEMBL Inhibition of MNK2 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
misshapen like kinase 1/Misshapen-like kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5518] [GtoPdb: 2103] [UniProtKB: Q8N4C8]
ChEMBL Inhibition of MINK (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
mitogen-activated protein kinase kinase kinase 5/Mitogen-activated protein kinase kinase kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5285] [GtoPdb: 2080] [UniProtKB: Q99683]
ChEMBL Inhibition of ASK1 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
mitogen-activated protein kinase kinase kinase 9/Mitogen-activated protein kinase kinase kinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2872] [GtoPdb: 2084] [UniProtKB: P80192]
ChEMBL Inhibition of MLK1 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
mitogen-activated protein kinase kinase kinase kinase 2/Mitogen-activated protein kinase kinase kinase kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5330] [GtoPdb: 2086] [UniProtKB: Q12851]
ChEMBL Inhibition of GCK (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
muscle associated receptor tyrosine kinase/Muscle, skeletal receptor tyrosine protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5684] [GtoPdb: 1847] [UniProtKB: O15146]
ChEMBL Inhibition of MUSK (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
Testicular receptor 4/Nuclear receptor subfamily 2 group C member 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5716] [GtoPdb: 614] [UniProtKB: P49116]
ChEMBL Inhibition of TAK1 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
PAS domain containing serine/threonine kinase/PAS domain-containing serine/threonine-protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6054] [GtoPdb: 2139] [UniProtKB: Q96RG2]
ChEMBL Inhibition of PASK (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
phosphatidylinositol 3-kinase catalytic subunit type 3/Phosphatidylinositol 3-kinase catalytic subunit type 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075165] [GtoPdb: 2152] [UniProtKB: Q8NEB9]
ChEMBL Inhibition of VPS34 (unknown origin) B 5.46 pIC50 >3500 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/PI3-kinase p110-alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4005] [GtoPdb: 2153] [UniProtKB: P42336]
ChEMBL Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate after 2 hrs by luminescence assay B 5.52 pIC50 >3000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
ChEMBL Inhibition of PI3Kalpha (unknown origin) B 5.52 pIC50 >3000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta/PI3-kinase p110-beta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3145] [GtoPdb: 2154] [UniProtKB: P42338]
ChEMBL Inhibition of PI3Kbeta (unknown origin) B 5.3 pIC50 >5000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta/PI3-kinase p110-delta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3130] [GtoPdb: 2155] [UniProtKB: O00329]
ChEMBL Inhibition of PI3Kdelta (unknown origin) B 5.3 pIC50 >5000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma/PI3-kinase p110-gamma subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3267] [GtoPdb: 2156] [UniProtKB: P48736]
ChEMBL Inhibition of PI3Kgamma (unknown origin) B 5.3 pIC50 >5000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
platelet derived growth factor receptor beta/Platelet-derived growth factor receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1913] [GtoPdb: 1804] [UniProtKB: P09619]
ChEMBL Inhibition of PDGFRbeta (unknown origin) B 5.46 pIC50 >3500 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
protein kinase C alpha/Protein kinase C alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL299] [GtoPdb: 1482] [UniProtKB: P17252]
ChEMBL Inhibition of PKCalpha (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
protein kinase C beta/Protein kinase C beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3045] [GtoPdb: 1483] [UniProtKB: P05771]
ChEMBL Inhibition of PKCbeta2 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
ChEMBL Inhibition of PKCbeta1 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
protein kinase C delta/Protein kinase C delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2996] [GtoPdb: 1485] [UniProtKB: Q05655]
ChEMBL Inhibition of PKCdelta (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
protein kinase C epsilon/Protein kinase C epsilon in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3582] [GtoPdb: 1486] [UniProtKB: Q02156]
ChEMBL Inhibition of PKCepsilon (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
protein kinase C eta/Protein kinase C eta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3616] [GtoPdb: 1487] [UniProtKB: P24723]
ChEMBL Inhibition of PKCeta (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
protein kinase C gamma/Protein kinase C gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2938] [GtoPdb: 1484] [UniProtKB: P05129]
ChEMBL Inhibition of PKCgamma (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
protein kinase C iota/Protein kinase C iota in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2598] [GtoPdb: 1490] [UniProtKB: P41743]
ChEMBL Inhibition of PKCiota (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
protein kinase D1/Protein kinase C mu in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3863] [GtoPdb: 1489] [UniProtKB: Q15139]
ChEMBL Inhibition of PKCmu (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
protein kinase C theta/Protein kinase C theta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3920] [GtoPdb: 1488] [UniProtKB: Q04759]
ChEMBL Inhibition of PKCtheta (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
protein kinase C zeta/Protein kinase C zeta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3438] [GtoPdb: 1491] [UniProtKB: Q05513]
ChEMBL Inhibition of PKCzeta (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
protein kinase N2/Protein kinase N2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3032] [GtoPdb: 1521] [UniProtKB: Q16513]
ChEMBL Inhibition of PRK2 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
protein tyrosine kinase 2 beta/Protein tyrosine kinase 2 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5469] [GtoPdb: 2181] [UniProtKB: Q14289]
ChEMBL Inhibition of PYK2 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
MER proto-oncogene, tyrosine kinase/Proto-oncogene tyrosine-protein kinase MER in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5331] [GtoPdb: 1837] [UniProtKB: Q12866]
ChEMBL Inhibition of MER (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
c-ros oncogene 1, receptor tyrosine kinase/Proto-oncogene tyrosine-protein kinase ROS in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5568] [GtoPdb: 1840] [UniProtKB: P08922]
ChEMBL Inhibition of ROS (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
pyruvate dehydrogenase kinase 1/Pyruvate dehydrogenase kinase isoform 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4766] [GtoPdb: 2915] [UniProtKB: Q15118]
ChEMBL Inhibition of PDK1 (unknown origin) B 5.46 pIC50 >3500 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
erb-b2 receptor tyrosine kinase 2/Receptor protein-tyrosine kinase erbB-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1824] [GtoPdb: 2019] [UniProtKB: P04626]
ChEMBL Inhibition of ERBB2 (unknown origin) B 5.46 pIC50 >3500 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
Rho associated coiled-coil containing protein kinase 1/Rho-associated protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3231] [GtoPdb: 1503] [UniProtKB: Q13464]
ChEMBL Inhibition of ROCK1 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
Rho associated coiled-coil containing protein kinase 2/Rho-associated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2973] [GtoPdb: 1504] [UniProtKB: O75116]
ChEMBL Inhibition of ROCK2 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
ribosomal protein S6 kinase B1/Ribosomal protein S6 kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4501] [GtoPdb: 1525] [UniProtKB: P23443]
ChEMBL Inhibition of p70S6K (unknown origin) B 5.46 pIC50 >3500 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
ribosomal protein S6 kinase A1/Ribosomal protein S6 kinase alpha 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2553] [GtoPdb: 1527] [UniProtKB: Q15418]
ChEMBL Inhibition of RSK1 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
ribosomal protein S6 kinase A2/Ribosomal protein S6 kinase alpha 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3906] [GtoPdb: 1529] [UniProtKB: Q15349]
ChEMBL Inhibition of RSK3 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
ribosomal protein S6 kinase A3/Ribosomal protein S6 kinase alpha 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2345] [GtoPdb: 1528] [UniProtKB: P51812]
ChEMBL Inhibition of RSK2 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
ribosomal protein S6 kinase A5/Ribosomal protein S6 kinase alpha 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4237] [GtoPdb: 1523] [UniProtKB: O75582]
ChEMBL Inhibition of MSK1 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
ribosomal protein S6 kinase A6/Ribosomal protein S6 kinase alpha 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4924] [GtoPdb: 1530] [UniProtKB: Q9UK32]
ChEMBL Inhibition of RSK4 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
serine/threonine kinase 10/Serine/threonine-protein kinase 10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3981] [GtoPdb: 2211] [UniProtKB: O94804]
ChEMBL Inhibition of LOK (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
serine/threonine kinase 11/Serine/threonine-protein kinase 11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5606] [GtoPdb: 2212] [UniProtKB: Q15831]
ChEMBL Inhibition of LKB1 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
serine/threonine kinase 33/Serine/threonine-protein kinase 33 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6005] [GtoPdb: 2221] [UniProtKB: Q9BYT3]
ChEMBL Inhibition of STK33 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
AKT serine/threonine kinase 1/Serine/threonine-protein kinase AKT in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4282] [GtoPdb: 1479] [UniProtKB: P31749]
ChEMBL Inhibition of AKT1 (unknown origin) B 5.46 pIC50 >3500 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
AKT serine/threonine kinase 2/Serine/threonine-protein kinase AKT2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2431] [GtoPdb: 1480] [UniProtKB: P31751]
ChEMBL Inhibition of AKT2 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
AKT serine/threonine kinase 3/Serine/threonine-protein kinase AKT3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4816] [GtoPdb: 2286] [UniProtKB: Q9Y243]
ChEMBL Inhibition of AKT3 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
aurora kinase A/Serine/threonine-protein kinase Aurora-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965]
ChEMBL Inhibition of Aurora kinase A (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
checkpoint kinase 1/Serine/threonine-protein kinase Chk1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4630] [GtoPdb: 1987] [UniProtKB: O14757]
ChEMBL Inhibition of CHK1 (unknown origin) B 5.46 pIC50 >3500 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
checkpoint kinase 2/Serine/threonine-protein kinase Chk2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2527] [GtoPdb: 1988] [UniProtKB: O96017]
ChEMBL Inhibition of CHK2 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
protein kinase D2/Serine/threonine-protein kinase D2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4900] [GtoPdb: 2173] [UniProtKB: Q9BZL6]
ChEMBL Inhibition of PKD2 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
histone H3 associated protein kinase/Serine/threonine-protein kinase haspin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075163] [GtoPdb: 2028] [UniProtKB: Q8TF76]
ChEMBL Inhibition of Haspin (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
microtubule affinity regulating kinase 1/Serine/threonine-protein kinase MARK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5940] [GtoPdb: 2097] [UniProtKB: Q9P0L2]
ChEMBL Inhibition of MARK1 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
serine/threonine kinase 4/Serine/threonine-protein kinase MST1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4598] [GtoPdb: 2225] [UniProtKB: Q13043]
ChEMBL Inhibition of MST1 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
NIMA related kinase 2/Serine/threonine-protein kinase NEK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3835] [GtoPdb: 2117] [UniProtKB: P51955]
ChEMBL Inhibition of NEK2 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
NIMA related kinase 7/Serine/threonine-protein kinase NEK7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4849] [GtoPdb: 2122] [UniProtKB: Q8TDX7]
ChEMBL Inhibition of NEK7 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
nemo like kinase/Serine/threonine protein kinase NLK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5364] [GtoPdb: 2125] [UniProtKB: Q9UBE8]
ChEMBL Inhibition of NLK (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
p21 (RAC1) activated kinase 3/Serine/threonine-protein kinase PAK 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2999] [GtoPdb: 2135] [UniProtKB: O75914]
ChEMBL Inhibition of PAK3 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
p21 (RAC1) activated kinase 6/Serine/threonine-protein kinase PAK6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4311] [GtoPdb: 2137] [UniProtKB: Q9NQU5]
ChEMBL Inhibition of PAK6 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
Pim-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2147] [GtoPdb: 2158] [UniProtKB: P11309]
ChEMBL Inhibition of PIM1 (unknown origin) B 5.46 pIC50 >3500 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
polo like kinase 1/Serine/threonine-protein kinase PLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3024] [GtoPdb: 2168] [UniProtKB: P53350]
ChEMBL Inhibition of PLK1 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
polo like kinase 3/Serine/threonine-protein kinase PLK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4897] [GtoPdb: 2170] [UniProtKB: Q9H4B4]
ChEMBL Inhibition of PLK3 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
Raf-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase RAF in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1906] [GtoPdb: 2184] [UniProtKB: P04049]
ChEMBL Inhibition of cRAF (unknown origin) B 5.46 pIC50 >3500 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
receptor interacting serine/threonine kinase 2/Serine/threonine-protein kinase RIPK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5014] [GtoPdb: 2190] [UniProtKB: O43353]
ChEMBL Inhibition of RIPK2 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
serum/glucocorticoid regulated kinase 1/Serine/threonine-protein kinase Sgk1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2343] [GtoPdb: 1534] [UniProtKB: O00141]
ChEMBL Inhibition of SGK (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
serum/glucocorticoid regulated kinase 2/Serine/threonine-protein kinase Sgk2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5794] [GtoPdb: 1535] [UniProtKB: Q9HBY8]
ChEMBL Inhibition of SGK2 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
serum/glucocorticoid regulated kinase family member 3/Serine/threonine-protein kinase Sgk3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6186] [GtoPdb: 1536] [UniProtKB: Q96BR1]
ChEMBL Inhibition of SGK3 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
SRSF protein kinase 3/Serine/threonine-protein kinase SRPK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5415] [GtoPdb: 2210] [UniProtKB: Q9UPE1]
ChEMBL Inhibition of MSSK1 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
TAO kinase 1/Serine/threonine-protein kinase TAO1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5261] [GtoPdb: 2233] [UniProtKB: Q7L7X3]
ChEMBL Inhibition of TAO1 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
TANK binding kinase 1/Serine/threonine-protein kinase TBK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5408] [GtoPdb: 2237] [UniProtKB: Q9UHD2]
ChEMBL Inhibition of TBK1 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
unc-51 like autophagy activating kinase 2/Serine/threonine-protein kinase ULK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5435] [GtoPdb: 2272] [UniProtKB: Q8IYT8]
ChEMBL Inhibition of ULK2 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
VRK serine/threonine kinase 2/Serine/threonine-protein kinase VRK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1649059] [GtoPdb: 2276] [UniProtKB: Q86Y07]
ChEMBL Inhibition of VRK2 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
WNK lysine deficient protein kinase 2/Serine/threonine-protein kinase WNK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5639] [GtoPdb: 2281] [UniProtKB: Q9Y3S1]
ChEMBL Inhibition of WNK2 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
KIT proto-oncogene, receptor tyrosine kinase/Stem cell growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1936] [GtoPdb: 1805] [UniProtKB: P10721]
ChEMBL Inhibition of KIT (unknown origin) B 5.46 pIC50 >3500 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
testis specific serine kinase 1B/Testis-specific serine/threonine-protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6003] [GtoPdb: 2257] [UniProtKB: Q9BXA7]
ChEMBL Inhibition of TSSK1 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
tyrosine kinase non receptor 2/Tyrosine kinase non-receptor protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4599] [GtoPdb: 2246] [UniProtKB: Q07912]
ChEMBL Inhibition of ACK1 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519]
ChEMBL Inhibition of ABL (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
ABL proto-oncogene 2, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4014] [GtoPdb: 1924] [UniProtKB: P42684]
ChEMBL Inhibition of ARG (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
BLK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase BLK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2250] [GtoPdb: 1940] [UniProtKB: P51451]
ChEMBL Inhibition of BLK (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
protein tyrosine kinase 6/Tyrosine-protein kinase BRK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4601] [GtoPdb: 2182] [UniProtKB: Q13882]
ChEMBL Inhibition of BRK (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
C-terminal Src kinase/Tyrosine-protein kinase CSK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2634] [GtoPdb: 1994] [UniProtKB: P41240]
ChEMBL Inhibition of CSK (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
FES proto-oncogene, tyrosine kinase/Tyrosine-protein kinase FES in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5455] [GtoPdb: 2023] [UniProtKB: P07332]
ChEMBL Inhibition of FES (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
HCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase HCK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3234] [GtoPdb: 2032] [UniProtKB: P08631]
ChEMBL Inhibition of HCK (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
IL2 inducible T cell kinase/Tyrosine-protein kinase ITK/TSK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2959] [GtoPdb: 2046] [UniProtKB: Q08881]
ChEMBL Inhibition of ITK (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
Janus kinase 2/Tyrosine-protein kinase JAK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674]
ChEMBL Inhibition of JAK2 (unknown origin) B 5.46 pIC50 >3500 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
LYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Lyn in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3905] [GtoPdb: 2060] [UniProtKB: P07948]
ChEMBL Inhibition of LYN (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
fms related receptor tyrosine kinase 3/Tyrosine-protein kinase receptor FLT3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1974] [GtoPdb: 1807] [UniProtKB: P36888]
ChEMBL Inhibition of FLT3 (unknown origin) B 5.46 pIC50 >3500 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
ret proto-oncogene/Tyrosine-protein kinase receptor RET in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2041] [GtoPdb: 2185] [UniProtKB: P07949]
ChEMBL Inhibition of RET (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
TYRO3 protein tyrosine kinase/Tyrosine-protein kinase receptor TYRO3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5314] [GtoPdb: 1836] [UniProtKB: Q06418]
ChEMBL Inhibition of RSE (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
AXL receptor tyrosine kinase/Tyrosine-protein kinase receptor UFO in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4895] [GtoPdb: 1835] [UniProtKB: P30530]
ChEMBL Inhibition of AXL (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931]
ChEMBL Inhibition of SRC (unknown origin) B 5.46 pIC50 >3500 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
YES proto-oncogene 1, Src family tyrosine kinase/Tyrosine-protein kinase YES in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073] [GtoPdb: 2284] [UniProtKB: P07947]
ChEMBL Inhibition of YES (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
zeta chain of T cell receptor associated protein kinase 70/Tyrosine-protein kinase ZAP-70 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2803] [GtoPdb: 2285] [UniProtKB: P43403]
ChEMBL Inhibition of ZAP70 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
fms related receptor tyrosine kinase 1/Vascular endothelial growth factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1868] [GtoPdb: 1812] [UniProtKB: P17948]
ChEMBL Inhibition of FLT1 (unknown origin) B 5.46 pIC50 >3500 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968]
ChEMBL Inhibition of KDR (unknown origin) B 5.46 pIC50 >3500 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
mechanistic target of rapamycin kinase in Human [GtoPdb: 2109] [UniProtKB: P42345]
GtoPdb - - 8 pIC50 9.9 nM IC50 J Med Chem (2013) 56: 2218-34 [PMID:23394126]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]