[3H]ancriviroc [Ligand Id: 802] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL78535 (SCH351125, Ancriviroc)
  • CCR5/C-C chemokine receptor type 5 in Human [ChEMBL: CHEMBL274] [GtoPdb: 62] [UniProtKB: P51681]
  • CCR5/C-C chemokine receptor type 5 in Mouse [ChEMBL: CHEMBL3676] [GtoPdb: 62] [UniProtKB: P51682]
  • 8.68
1 CHEMBL78535_lig_chart_1 C-C chemokine receptor type 5 HumanMouse
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
CCR5/C-C chemokine receptor type 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL274] [GtoPdb: 62] [UniProtKB: P51681]
GtoPdb - - 8.9 pKd - - - Antimicrob Agents Chemother (2005) 49: 4911-9 [PMID:16304152]
ChEMBL Inhibition of RANTES binding to C-C chemokine receptor type 5 B 8.68 pKi 2.1 nM Ki J. Med. Chem. (2001) 44: 3339-3342 [PMID:11585437]
ChEMBL Inhibition of RANTES binding to the human C-C chemokine receptor type 5 (CCR5) B 8.68 pKi 2.1 nM Ki J. Med. Chem. (2003) 46: 4501-4515 [PMID:14521412]
CCR5/C-C chemokine receptor type 5 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3676] [GtoPdb: 62] [UniProtKB: P51682]
ChEMBL Inhibition of RANTES binding to Chemokine receptor type 5 receptor from NIH 3T3 cells B 8.68 pKi 2.1 nM Ki J. Med. Chem. (2002) 45: 3143-3160 [PMID:12086500]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]