[3H]ancriviroc [Ligand Id: 802] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL78535 (Ancriviroc, SCH-351125, SCH351125) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CCR5/C-C chemokine receptor type 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL274] [GtoPdb: 62] [UniProtKB: P51681] | ||||||||
| GtoPdb | - | - | 8.9 | pKd | - | - | - | Antimicrob Agents Chemother (2005) 49: 4911-9 [PMID:16304152] |
| ChEMBL | Inhibition of RANTES binding to C-C chemokine receptor type 5 | B | 8.68 | pKi | 2.1 | nM | Ki | J Med Chem (2001) 44: 3339-3342 [PMID:11585437] |
| ChEMBL | Inhibition of RANTES binding to the human C-C chemokine receptor type 5 (CCR5) | B | 8.68 | pKi | 2.1 | nM | Ki | J Med Chem (2003) 46: 4501-4515 [PMID:14521412] |
| ChEMBL | Binding affinity to CCR5 | B | 8.7 | pKi | 2 | nM | Ki | J Med Chem (2012) 55: 9363-9392 [PMID:22931505] |
| CCR5/C-C chemokine receptor type 5 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3676] [GtoPdb: 62] [UniProtKB: P51682] | ||||||||
| ChEMBL | Inhibition of RANTES binding to Chemokine receptor type 5 receptor from NIH 3T3 cells | B | 8.68 | pKi | 2.1 | nM | Ki | J Med Chem (2002) 45: 3143-3160 [PMID:12086500] |
ChEMBL data shown on this page come from version 35:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
