HX 531 [Ligand Id: 8079] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL326525
  • Retinoid X receptor-α/Retinoid X receptor alpha in Human [ChEMBL: CHEMBL2061] [GtoPdb: 610] [UniProtKB: P19793]
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  • Retinoid X receptor-β/Retinoid X receptor beta in Human [ChEMBL: CHEMBL1870] [GtoPdb: 611] [UniProtKB: P28702]
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  • Retinoid X receptor-γ/Retinoid X receptor gamma in Human [ChEMBL: CHEMBL2004] [GtoPdb: 612] [UniProtKB: P48443]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Retinoid X receptor-α/Retinoid X receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2061] [GtoPdb: 610] [UniProtKB: P19793]
ChEMBL Antagonist activity at human RXRalpha expressed in EK293 cells assessed as inhibition of LG-100268-induced transactivation F 5.92 pIC50 1200 nM IC50 Bioorg. Med. Chem. Lett. (2007) 17: 4808-4811 [PMID:17651969]
ChEMBL Antagonist activity at human RXRalpha expressed in EK293 cells assessed as inhibition of 9-cis-retinoic acid-induced transactivation F 6.05 pIC50 900 nM IC50 Bioorg. Med. Chem. Lett. (2007) 17: 4808-4811 [PMID:17651969]
GtoPdb Measuring inhibition of agonist-induced activation of RXRα. - 6.05 pIC50 900 nM IC50 Bioorg. Med. Chem. Lett. (2007) 17: 4808-11 [PMID:17651969]
ChEMBL Antagonist activity at RXRalpha expressed in african green monkey COS1 cells assessed as inhibition of LGD-1069-induced agonist activity F 6.54 pIC50 290 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 1001-1003 [PMID:19095448]
Retinoid X receptor-β/Retinoid X receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1870] [GtoPdb: 611] [UniProtKB: P28702]
ChEMBL Antagonist activity at RXRbeta expressed in african green monkey COS1 cells assessed as inhibition of LGD-1069-induced agonist activity F 7.36 pIC50 44 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 1001-1003 [PMID:19095448]
Retinoid X receptor-γ/Retinoid X receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2004] [GtoPdb: 612] [UniProtKB: P48443]
ChEMBL Antagonist activity at RXRgamma expressed in african green monkey COS1 cells assessed as inhibition of LGD-1069-induced agonist activity F 6.42 pIC50 380 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 1001-1003 [PMID:19095448]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]