HX 531 [Ligand Id: 8079] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL326525 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Retinoid X receptor-α/Retinoid X receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2061] [GtoPdb: 610] [UniProtKB: P19793] | ||||||||
| ChEMBL | Antagonist activity at human RXRalpha expressed in EK293 cells assessed as inhibition of LG-100268-induced transactivation | F | 5.92 | pIC50 | 1200 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 4808-4811 [PMID:17651969] |
| ChEMBL | Antagonist activity at human RXRalpha expressed in EK293 cells assessed as inhibition of 9-cis-retinoic acid-induced transactivation | F | 6.05 | pIC50 | 900 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 4808-4811 [PMID:17651969] |
| GtoPdb | Measuring inhibition of agonist-induced activation of RXRα. | - | 6.05 | pIC50 | 900 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 4808-11 [PMID:17651969] |
| ChEMBL | Antagonist activity at RXRalpha expressed in african green monkey COS1 cells assessed as inhibition of LGD-1069-induced agonist activity | F | 6.54 | pIC50 | 290 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 1001-1003 [PMID:19095448] |
| Retinoid X receptor-β/Retinoid X receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1870] [GtoPdb: 611] [UniProtKB: P28702] | ||||||||
| ChEMBL | Antagonist activity at RXRbeta expressed in african green monkey COS1 cells assessed as inhibition of LGD-1069-induced agonist activity | F | 7.36 | pIC50 | 44 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 1001-1003 [PMID:19095448] |
| Retinoid X receptor-γ/Retinoid X receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2004] [GtoPdb: 612] [UniProtKB: P48443] | ||||||||
| ChEMBL | Antagonist activity at RXRgamma expressed in african green monkey COS1 cells assessed as inhibition of LGD-1069-induced agonist activity | F | 6.42 | pIC50 | 380 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 1001-1003 [PMID:19095448] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
