Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
ChEMBL ligand: CHEMBL501724 |
---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
---|---|---|---|---|---|---|---|---|
casein kinase 2, beta polypeptide subunit/casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II alpha/beta in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3038477] [GtoPdb: 1551, 1549] [UniProtKB: P67870, P68400] | ||||||||
ChEMBL | Inhibition of human tertrameric CK2alphabeta holoenzyme using casein as substrate after 1 to 2 hrs by chemiluminescence assay in presence of 2 uM ATP | B | 7.72 | pIC50 | 19 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 3727-3731 [PMID:22560567] |
cell division cycle 7/Cell division cycle 7-related protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5443] [GtoPdb: 1960] [UniProtKB: O00311] | ||||||||
ChEMBL | Inhibition of CDC7-DBF4 | B | 8.52 | pIC50 | 3 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 4482-4485 [PMID:18672368] |
GtoPdb | - | - | 8.85 | pIC50 | 1.4 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 3727-31 [PMID:22560567] |
ChEMBL | Inhibition of N-terminus Myc-tagged human CDC7 expressed in Escherichia coli by chemiluminescence assay in presence of ATP | B | 8.85 | pIC50 | 1.4 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 3727-3731 [PMID:22560567] |
CDC like kinase 1/Dual specificty protein kinase CLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4224] [GtoPdb: 1990] [UniProtKB: P49759] | ||||||||
ChEMBL | Inhibition of CLK1 | B | 6.68 | pIC50 | 210 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 1429-1433 [PMID:21295469] |
GtoPdb | - | - | 6.68 | pIC50 | 210 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 1429-33 [PMID:21295469] |
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841] | ||||||||
ChEMBL | Inhibition of human GSK3-beta expressed in CHO AA8 cells co-expressing human tau protein after 2 hrs | B | 5.28 | pIC50 | >5280 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 1429-1433 [PMID:21295469] |
GtoPdb | - | - | 7.76 | pIC50 | 17.2 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 1429-33 [PMID:21295469] |
ChEMBL | Inhibition of human recombinant GSK3-beta expressed in baculovirus infected SF9 cells after 60 mins | B | 7.76 | pIC50 | 17.2 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 1429-1433 [PMID:21295469] |
Pim-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2147] [GtoPdb: 2158] [UniProtKB: P11309] | ||||||||
ChEMBL | Inhibition of N-terminus His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by chemiluminescence assay | B | 6.48 | pIC50 | 332 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 3727-3731 [PMID:22560567] |
GtoPdb | - | - | 6.48 | pIC50 | 332 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 3727-31 [PMID:22560567] |
Casein kinase 2 in Human [GtoPdb: 1548] | ||||||||
GtoPdb | - | - | 7.72 | pIC50 | 19 | nM | IC50 |
Bioorg Med Chem Lett (2012) 22: 3727-31 [PMID:22560567]; Bioorg Med Chem Lett (2011) 21: 1429-33 [PMID:21295469] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]