ChEMBL ligand: CHEMBL2070615
testis associated actin remodelling kinase 1/Dual specificity testis-specific protein kinase 1 in Human [ChEMBL: CHEMBL5604] [GtoPdb: 2239] [UniProtKB: Q15569] There should be some charts here, you may need to enable JavaScript!
testis associated actin remodelling kinase 2/Dual specificity testis-specific protein kinase 2 in Human [ChEMBL: CHEMBL2069163] [GtoPdb: 2240] [UniProtKB: Q96S53] There should be some charts here, you may need to enable JavaScript!
LIM domain kinase 1 in Human [ChEMBL: CHEMBL3836] [GtoPdb: 2054] [UniProtKB: P53667] There should be some charts here, you may need to enable JavaScript!
LIM domain kinase 2 in Human [ChEMBL: CHEMBL5932] [GtoPdb: 2055] [UniProtKB: P53671] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
testis associated actin remodelling kinase 1/Dual specificity testis-specific protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5604] [GtoPdb: 2239] [UniProtKB: Q15569]
GtoPdb	-	-	6.34	pIC50	455	nM	IC50	Bioorg Med Chem Lett (2012) 22: 5995-8 [PMID:22902653]
ChEMBL	Inhibition of TESK1	B	6.34	pIC50	455	nM	IC50	Bioorg. Med. Chem. Lett. (2012) 22: 5995-5998 [PMID:22902653]
testis associated actin remodelling kinase 2/Dual specificity testis-specific protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2069163] [GtoPdb: 2240] [UniProtKB: Q96S53]
ChEMBL	Inhibition of TESK2	B	6.6	pIC50	252	nM	IC50	Bioorg. Med. Chem. Lett. (2012) 22: 5995-5998 [PMID:22902653]
GtoPdb	-	-	6.6	pIC50	252	nM	IC50	Bioorg Med Chem Lett (2012) 22: 5995-8 [PMID:22902653]
LIM domain kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3836] [GtoPdb: 2054] [UniProtKB: P53667]
ChEMBL	Inhibition of LIMK1	B	7.24	pIC50	58	nM	IC50	Bioorg. Med. Chem. Lett. (2012) 22: 5995-5998 [PMID:22902653]
GtoPdb	-	-	7.24	pIC50	58	nM	IC50	Bioorg Med Chem Lett (2012) 22: 5995-8 [PMID:22902653]
ChEMBL	Inhibition of LIMK1 (unknown origin) assessed as ADP formation using cofilin-2 protein as substrate measured after 60 mins incubation with enzyme by Transcreener assay	B	7.27	pIC50	54	nM	IC50	MedChemComm (2011) 2: 982-986
ChEMBL	Inhibition of LIMK1-catalyzed cofilin phosphorylation in human ZR-75-1 cells	B	9	pIC50	1	nM	IC50	MedChemComm (2011) 2: 982-986
LIM domain kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5932] [GtoPdb: 2055] [UniProtKB: P53671]
ChEMBL	Inhibition of LIMK2 (unknown origin)	B	6.16	pIC50	696	nM	IC50	MedChemComm (2011) 2: 982-986
GtoPdb	-	-	7.42	pIC50	38	nM	IC50	Bioorg Med Chem Lett (2012) 22: 5995-8 [PMID:22902653]
ChEMBL	Inhibition of LIMK2	B	7.42	pIC50	38	nM	IC50	Bioorg. Med. Chem. Lett. (2012) 22: 5995-5998 [PMID:22902653]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]