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ChEMBL ligand: CHEMBL2070615 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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testis associated actin remodelling kinase 1/Dual specificity testis-specific protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5604] [GtoPdb: 2239] [UniProtKB: Q15569] | ||||||||
GtoPdb | - | - | 6.34 | pIC50 | 455 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 5995-8 [PMID:22902653] |
ChEMBL | Inhibition of TESK1 | B | 6.34 | pIC50 | 455 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 5995-5998 [PMID:22902653] |
testis associated actin remodelling kinase 2/Dual specificity testis-specific protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2069163] [GtoPdb: 2240] [UniProtKB: Q96S53] | ||||||||
ChEMBL | Inhibition of TESK2 | B | 6.6 | pIC50 | 252 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 5995-5998 [PMID:22902653] |
GtoPdb | - | - | 6.6 | pIC50 | 252 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 5995-8 [PMID:22902653] |
LIM domain kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3836] [GtoPdb: 2054] [UniProtKB: P53667] | ||||||||
ChEMBL | Inhibition of LIMK1 | B | 7.24 | pIC50 | 58 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 5995-5998 [PMID:22902653] |
GtoPdb | - | - | 7.24 | pIC50 | 58 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 5995-8 [PMID:22902653] |
ChEMBL | Inhibition of LIMK1 (unknown origin) assessed as ADP formation using cofilin-2 protein as substrate measured after 60 mins incubation with enzyme by Transcreener assay | B | 7.27 | pIC50 | 54 | nM | IC50 | Medchemcomm (2011) 2: 982-986 |
ChEMBL | Inhibition of LIMK1-catalyzed cofilin phosphorylation in human ZR-75-1 cells | B | 9 | pIC50 | 1 | nM | IC50 | Medchemcomm (2011) 2: 982-986 |
LIM domain kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5932] [GtoPdb: 2055] [UniProtKB: P53671] | ||||||||
ChEMBL | Inhibition of LIMK2 (unknown origin) | B | 6.16 | pIC50 | 696 | nM | IC50 | Medchemcomm (2011) 2: 982-986 |
GtoPdb | - | - | 7.42 | pIC50 | 38 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 5995-8 [PMID:22902653] |
ChEMBL | Inhibition of LIMK2 | B | 7.42 | pIC50 | 38 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 5995-5998 [PMID:22902653] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]