compound 13d [PMID: 23639540] [Ligand Id: 8120] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2385582
  • activin A receptor type 1/Activin receptor type-1 in Human [ChEMBL: CHEMBL5903] [GtoPdb: 1785] [UniProtKB: Q04771]
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  • activin A receptor type 1B/Activin receptor type-1B in Human [ChEMBL: CHEMBL5310] [GtoPdb: 1787] [UniProtKB: P36896]
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  • protein kinase AMP-activated non-catalytic subunit beta 1/AMP-activated protein kinase, beta-1 subunit in Human [ChEMBL: CHEMBL3847] [GtoPdb: 1543] [UniProtKB: Q9Y478]
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  • bone morphogenetic protein receptor type IA/Bone morphogenetic protein receptor type-1A in Human [ChEMBL: CHEMBL5275] [GtoPdb: 1786] [UniProtKB: P36894]
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  • bone morphogenetic protein receptor type IB/Bone morphogenetic protein receptor type-1B in Human [ChEMBL: CHEMBL5476] [GtoPdb: 1789] [UniProtKB: O00238]
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  • bone morphogenetic protein receptor type 2/Bone morphogenetic protein receptor type-2 in Human [ChEMBL: CHEMBL5467] [GtoPdb: 1794] [UniProtKB: Q13873]
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  • activin A receptor type IL/Serine/threonine-protein kinase receptor R3 in Human [ChEMBL: CHEMBL5311] [GtoPdb: 1784] [UniProtKB: P37023]
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  • transforming growth factor beta receptor 1/TGF-beta receptor type I in Human [ChEMBL: CHEMBL4439] [GtoPdb: 1788] [UniProtKB: P36897]
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  • transforming growth factor beta receptor 2/TGF-beta receptor type II in Human [ChEMBL: CHEMBL4267] [GtoPdb: 1795] [UniProtKB: P37173]
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  • kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
activin A receptor type 1/Activin receptor type-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5903] [GtoPdb: 1785] [UniProtKB: Q04771]
GtoPdb - - 8.3 pIC50 <5 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 3248-52 [PMID:23639540]
ChEMBL Inhibition of ALK2 (unknown origin) B 8.3 pIC50 <5 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 3248-3252 [PMID:23639540]
activin A receptor type 1B/Activin receptor type-1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5310] [GtoPdb: 1787] [UniProtKB: P36896]
ChEMBL Inhibition of ALK4 (unknown origin) B 6.49 pIC50 326 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 3248-3252 [PMID:23639540]
GtoPdb - - 6.49 pIC50 326 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 3248-52 [PMID:23639540]
protein kinase AMP-activated non-catalytic subunit beta 1/AMP-activated protein kinase, beta-1 subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3847] [GtoPdb: 1543] [UniProtKB: Q9Y478]
ChEMBL Inhibition of AMPK (unknown origin) B 5.57 pIC50 2680 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 3248-3252 [PMID:23639540]
Bone morphogenetic protein 4 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2384894] [UniProtKB: P21275]
ChEMBL Inhibition of BMP4 in mouse C2C12BRA cells after 14 hrs by luciferase reporter gene assay B 9 pIC50 <1 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 3248-3252 [PMID:23639540]
bone morphogenetic protein receptor type IA/Bone morphogenetic protein receptor type-1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5275] [GtoPdb: 1786] [UniProtKB: P36894]
GtoPdb - - 8.3 pIC50 <5 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 3248-52 [PMID:23639540]
ChEMBL Inhibition of ALK3 (unknown origin) B 8.3 pIC50 <5 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 3248-3252 [PMID:23639540]
bone morphogenetic protein receptor type IB/Bone morphogenetic protein receptor type-1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5476] [GtoPdb: 1789] [UniProtKB: O00238]
GtoPdb - - 8.3 pIC50 <5 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 3248-52 [PMID:23639540]
ChEMBL Inhibition of ALK6 (unknown origin) B 8.3 pIC50 <5 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 3248-3252 [PMID:23639540]
bone morphogenetic protein receptor type 2/Bone morphogenetic protein receptor type-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5467] [GtoPdb: 1794] [UniProtKB: Q13873]
ChEMBL Inhibition of BMPR2 (unknown origin) B 5.44 pIC50 3640 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 3248-3252 [PMID:23639540]
activin A receptor type IL/Serine/threonine-protein kinase receptor R3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5311] [GtoPdb: 1784] [UniProtKB: P37023]
GtoPdb - - 8.3 pIC50 <5 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 3248-52 [PMID:23639540]
ChEMBL Inhibition of ALK1 (unknown origin) B 8.3 pIC50 <5 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 3248-3252 [PMID:23639540]
transforming growth factor beta receptor 1/TGF-beta receptor type I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4439] [GtoPdb: 1788] [UniProtKB: P36897]
ChEMBL Inhibition of ALK5 (unknown origin) B 6.75 pIC50 178 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 3248-3252 [PMID:23639540]
GtoPdb - - 6.75 pIC50 178 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 3248-52 [PMID:23639540]
transforming growth factor beta receptor 2/TGF-beta receptor type II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4267] [GtoPdb: 1795] [UniProtKB: P37173]
ChEMBL Inhibition of TGFBR2 (unknown origin) B 7.59 pIC50 26 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 3248-3252 [PMID:23639540]
GtoPdb - - 7.59 pIC50 26 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 3248-52 [PMID:23639540]
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968]
ChEMBL Inhibition of KDR (unknown origin) B 5.27 pIC50 5330 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 3248-3252 [PMID:23639540]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]