ML347 [Ligand Id: 8121] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL502351 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| activin A receptor type 1/Activin receptor type-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5903] [GtoPdb: 1785] [UniProtKB: Q04771] | ||||||||
| GtoPdb | - | - | 7.49 | pIC50 | 32 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3248-52 [PMID:23639540] |
| ChEMBL | Inhibition of ALK2 (unknown origin) | B | 7.49 | pIC50 | 32 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3248-3252 [PMID:23639540] |
| Bone morphogenetic protein 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5350] [UniProtKB: P12644] | ||||||||
| ChEMBL | Inhibition of BMP4-induced phosphorylation of SMAD 1/5/8 by cytoblot cellular ELISA | B | 5.52 | pIC50 | 3000 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 4388-4392 [PMID:18621530] |
| Bone morphogenetic protein 4 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2384894] [UniProtKB: P21275] | ||||||||
| ChEMBL | Inhibition of BMP4 in mouse C2C12BRA cells after 14 hrs by luciferase reporter gene assay | B | 6.82 | pIC50 | 152 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3248-3252 [PMID:23639540] |
| bone morphogenetic protein receptor type IA/Bone morphogenetic protein receptor type-1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5275] [GtoPdb: 1786] [UniProtKB: P36894] | ||||||||
| ChEMBL | Inhibition of ALK3 (unknown origin) | B | 4.97 | pIC50 | 10800 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3248-3252 [PMID:23639540] |
| GtoPdb | - | - | 4.97 | pIC50 | 10800 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3248-52 [PMID:23639540] |
| bone morphogenetic protein receptor type IB/Bone morphogenetic protein receptor type-1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5476] [GtoPdb: 1789] [UniProtKB: O00238] | ||||||||
| ChEMBL | Inhibition of ALK6 (unknown origin) | B | 5.01 | pIC50 | 9830 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3248-3252 [PMID:23639540] |
| activin A receptor type IL/Serine/threonine-protein kinase receptor R3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5311] [GtoPdb: 1784] [UniProtKB: P37023] | ||||||||
| ChEMBL | Inhibition of ALK1 (unknown origin) | B | 7.34 | pIC50 | 46 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3248-3252 [PMID:23639540] |
| GtoPdb | - | - | 7.34 | pIC50 | 46 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3248-52 [PMID:23639540] |
| kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968] | ||||||||
| ChEMBL | Inhibition of KDR (unknown origin) | B | 4.71 | pIC50 | 19700 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3248-3252 [PMID:23639540] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
