ML347 [Ligand Id: 8121] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL502351
  • activin A receptor type 1/Activin receptor type-1 in Human [ChEMBL: CHEMBL5903] [GtoPdb: 1785] [UniProtKB: Q04771]
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  • bone morphogenetic protein receptor type IA/Bone morphogenetic protein receptor type-1A in Human [ChEMBL: CHEMBL5275] [GtoPdb: 1786] [UniProtKB: P36894]
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  • bone morphogenetic protein receptor type IB/Bone morphogenetic protein receptor type-1B in Human [ChEMBL: CHEMBL5476] [GtoPdb: 1789] [UniProtKB: O00238]
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  • activin A receptor type IL/Serine/threonine-protein kinase receptor R3 in Human [ChEMBL: CHEMBL5311] [GtoPdb: 1784] [UniProtKB: P37023]
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  • kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
activin A receptor type 1/Activin receptor type-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5903] [GtoPdb: 1785] [UniProtKB: Q04771]
GtoPdb - - 7.49 pIC50 32 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 3248-52 [PMID:23639540]
ChEMBL Inhibition of ALK2 (unknown origin) B 7.49 pIC50 32 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 3248-3252 [PMID:23639540]
Bone morphogenetic protein 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5350] [UniProtKB: P12644]
ChEMBL Inhibition of BMP4-induced phosphorylation of SMAD 1/5/8 by cytoblot cellular ELISA B 5.52 pIC50 3000 nM IC50 Bioorg. Med. Chem. Lett. (2008) 18: 4388-4392 [PMID:18621530]
Bone morphogenetic protein 4 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2384894] [UniProtKB: P21275]
ChEMBL Inhibition of BMP4 in mouse C2C12BRA cells after 14 hrs by luciferase reporter gene assay B 6.82 pIC50 152 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 3248-3252 [PMID:23639540]
bone morphogenetic protein receptor type IA/Bone morphogenetic protein receptor type-1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5275] [GtoPdb: 1786] [UniProtKB: P36894]
ChEMBL Inhibition of ALK3 (unknown origin) B 4.97 pIC50 10800 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 3248-3252 [PMID:23639540]
GtoPdb - - 4.97 pIC50 10800 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 3248-52 [PMID:23639540]
bone morphogenetic protein receptor type IB/Bone morphogenetic protein receptor type-1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5476] [GtoPdb: 1789] [UniProtKB: O00238]
ChEMBL Inhibition of ALK6 (unknown origin) B 5.01 pIC50 9830 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 3248-3252 [PMID:23639540]
activin A receptor type IL/Serine/threonine-protein kinase receptor R3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5311] [GtoPdb: 1784] [UniProtKB: P37023]
ChEMBL Inhibition of ALK1 (unknown origin) B 7.34 pIC50 46 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 3248-3252 [PMID:23639540]
GtoPdb - - 7.34 pIC50 46 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 3248-52 [PMID:23639540]
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968]
ChEMBL Inhibition of KDR (unknown origin) B 4.71 pIC50 19700 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 3248-3252 [PMID:23639540]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]