compound 23 [PMID: 17600705] [Ligand Id: 8146] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL249317
  • LCK proto-oncogene, Src family tyrosine kinase in Human [GtoPdb: 2053] [UniProtKB: P06239]
  • LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Mouse [ChEMBL: CHEMBL2480] [GtoPdb: 2053] [UniProtKB: P06240]
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  • LYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Lyn in Human [ChEMBL: CHEMBL3905] [GtoPdb: 2060] [UniProtKB: P07948]
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  • spleen associated tyrosine kinase/Tyrosine-protein kinase SYK in Human [ChEMBL: CHEMBL2599] [GtoPdb: 2230] [UniProtKB: P43405]
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  • TXK tyrosine kinase/Tyrosine-protein kinase TXK in Human [ChEMBL: CHEMBL4367] [GtoPdb: 2268] [UniProtKB: P42681]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
LCK proto-oncogene, Src family tyrosine kinase in Human [GtoPdb: 2053] [UniProtKB: P06239]
GtoPdb - - 8.07 pIC50 8.5 nM IC50 Bioorg Med Chem Lett (2007) 17: 4363-8 [PMID:17600705]
LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2480] [GtoPdb: 2053] [UniProtKB: P06240]
ChEMBL Inhibition of murine Lck by TR-FRET assay B 8.07 pIC50 8.5 nM IC50 Bioorg. Med. Chem. Lett. (2007) 17: 4363-4368 [PMID:17600705]
LYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Lyn in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3905] [GtoPdb: 2060] [UniProtKB: P07948]
GtoPdb - - 9 pIC50 1 nM IC50 Bioorg Med Chem Lett (2007) 17: 4363-8 [PMID:17600705]
ChEMBL Inhibition of Lyn B 9 pIC50 1 nM IC50 Bioorg. Med. Chem. Lett. (2007) 17: 4363-4368 [PMID:17600705]
spleen associated tyrosine kinase/Tyrosine-protein kinase SYK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2599] [GtoPdb: 2230] [UniProtKB: P43405]
ChEMBL Inhibition of Syk B 8.4 pIC50 4 nM IC50 Bioorg. Med. Chem. Lett. (2007) 17: 4363-4368 [PMID:17600705]
GtoPdb - - 8.4 pIC50 4 nM IC50 Bioorg Med Chem Lett (2007) 17: 4363-8 [PMID:17600705]
TXK tyrosine kinase/Tyrosine-protein kinase TXK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4367] [GtoPdb: 2268] [UniProtKB: P42681]
ChEMBL Inhibition of Txk B 9.4 pIC50 0.4 nM IC50 Bioorg. Med. Chem. Lett. (2007) 17: 4363-4368 [PMID:17600705]
GtoPdb - - 9.4 pIC50 0.4 nM IC50 Bioorg Med Chem Lett (2007) 17: 4363-8 [PMID:17600705]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]