compound 14 [PMID: 19831390] [Ligand Id: 8151] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL570126
  • LIM domain kinase 1 in Human [ChEMBL: CHEMBL3836] [GtoPdb: 2054] [UniProtKB: P53667]
  • This target only has 0 pki data point
  • 0
1 CHEMBL570126_lig_chart_1 LIM domain kinase 1 Human
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  • LIM domain kinase 2 in Human [ChEMBL: CHEMBL5932] [GtoPdb: 2055] [UniProtKB: P53671]
  • This target only has 0 pki data point
  • 0
2 CHEMBL570126_lig_chart_2 LIM domain kinase 2 Human
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  • Rho associated coiled-coil containing protein kinase 1/Rho-associated protein kinase 1 in Human [ChEMBL: CHEMBL3231] [GtoPdb: 1503] [UniProtKB: Q13464]
  • This target only has 0 pki data point
  • 0
3 CHEMBL570126_lig_chart_3 Rho-associated protein kinase 1 Human
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  • Rho associated coiled-coil containing protein kinase 2/Rho-associated protein kinase 2 in Human [ChEMBL: CHEMBL2973] [GtoPdb: 1504] [UniProtKB: O75116]
  • This target only has 0 pki data point
  • 0
4 CHEMBL570126_lig_chart_4 Rho-associated protein kinase 2 Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
LIM domain kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3836] [GtoPdb: 2054] [UniProtKB: P53667]
GtoPdb - - 9.3 pIC50 0.5 nM IC50 J Med Chem (2009) 52: 6515-8 [PMID:19831390]
ChEMBL Inhibition of LIMK1 B 9.3 pIC50 0.5 nM IC50 J. Med. Chem. (2009) 52: 6515-6518 [PMID:19831390]
LIM domain kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5932] [GtoPdb: 2055] [UniProtKB: P53671]
ChEMBL Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation counting B 9.05 pIC50 0.9 nM IC50 J. Med. Chem. (2009) 52: 6515-6518 [PMID:19831390]
GtoPdb - - 9.05 pIC50 0.9 nM IC50 J Med Chem (2009) 52: 6515-8 [PMID:19831390]
Rho associated coiled-coil containing protein kinase 1/Rho-associated protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3231] [GtoPdb: 1503] [UniProtKB: Q13464]
ChEMBL Inhibition of human ROCK1 expressed in baculovirus system B 6.59 pIC50 260 nM IC50 J. Med. Chem. (2009) 52: 6515-6518 [PMID:19831390]
Rho associated coiled-coil containing protein kinase 2/Rho-associated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2973] [GtoPdb: 1504] [UniProtKB: O75116]
ChEMBL Inhibition of human ROCK2 B 5.57 pIC50 2700 nM IC50 J. Med. Chem. (2009) 52: 6515-6518 [PMID:19831390]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]