compound 14 [PMID: 19831390] [Ligand Id: 8151] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL570126
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  • Rho associated coiled-coil containing protein kinase 1/Rho-associated protein kinase 1 in Human [ChEMBL: CHEMBL3231] [GtoPdb: 1503] [UniProtKB: Q13464]
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  • Rho associated coiled-coil containing protein kinase 2/Rho-associated protein kinase 2 in Human [ChEMBL: CHEMBL2973] [GtoPdb: 1504] [UniProtKB: O75116]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
LIM domain kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3836] [GtoPdb: 2054] [UniProtKB: P53667]
GtoPdb - - 9.3 pIC50 0.5 nM IC50 J Med Chem (2009) 52: 6515-8 [PMID:19831390]
ChEMBL Inhibition of LIMK1 B 9.3 pIC50 0.5 nM IC50 J Med Chem (2009) 52: 6515-6518 [PMID:19831390]
LIM domain kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5932] [GtoPdb: 2055] [UniProtKB: P53671]
ChEMBL Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation counting B 9.05 pIC50 0.9 nM IC50 J Med Chem (2009) 52: 6515-6518 [PMID:19831390]
GtoPdb - - 9.05 pIC50 0.9 nM IC50 J Med Chem (2009) 52: 6515-8 [PMID:19831390]
Rho associated coiled-coil containing protein kinase 1/Rho-associated protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3231] [GtoPdb: 1503] [UniProtKB: Q13464]
ChEMBL Inhibition of human ROCK1 expressed in baculovirus system B 6.59 pIC50 260 nM IC50 J Med Chem (2009) 52: 6515-6518 [PMID:19831390]
Rho associated coiled-coil containing protein kinase 2/Rho-associated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2973] [GtoPdb: 1504] [UniProtKB: O75116]
ChEMBL Inhibition of human ROCK2 B 5.57 pIC50 2700 nM IC50 J Med Chem (2009) 52: 6515-6518 [PMID:19831390]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]