compound 17 [PMID: 23642479] [Ligand Id: 8161] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2392364
  • CDC like kinase 2/Dual specificity protein kinase CLK2 in Human [ChEMBL: CHEMBL4225] [GtoPdb: 1991] [UniProtKB: P49760]
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  • CDC like kinase 3/Dual specificity protein kinase CLK3 in Human [ChEMBL: CHEMBL4226] [GtoPdb: 1992] [UniProtKB: P49761]
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  • CDC like kinase 4/Dual specificity protein kinase CLK4 in Human [ChEMBL: CHEMBL4203] [GtoPdb: 1993] [UniProtKB: Q9HAZ1]
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  • dual specificity tyrosine phosphorylation regulated kinase 1A/Dual-specificity tyrosine-phosphorylation regulated kinase 1A in Human [ChEMBL: CHEMBL2292] [GtoPdb: 2009] [UniProtKB: Q13627]
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  • dual specificity tyrosine phosphorylation regulated kinase 1B/Dual specificity tyrosine-phosphorylation-regulated kinase 1B in Human [ChEMBL: CHEMBL5543] [GtoPdb: 2010] [UniProtKB: Q9Y463]
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  • CDC like kinase 1/Dual specificty protein kinase CLK1 in Human [ChEMBL: CHEMBL4224] [GtoPdb: 1990] [UniProtKB: P49759]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
CDC like kinase 2/Dual specificity protein kinase CLK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4225] [GtoPdb: 1991] [UniProtKB: P49760]
ChEMBL Inhibition of CLK2 (unknown origin) B 7.64 pIC50 23 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 3654-3661 [PMID:23642479]
GtoPdb - - 7.64 pIC50 23 nM IC50 Bioorg Med Chem Lett (2013) 23: 3654-61 [PMID:23642479]
CDC like kinase 3/Dual specificity protein kinase CLK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4226] [GtoPdb: 1992] [UniProtKB: P49761]
ChEMBL Inhibition of CLK3 (unknown origin) B 5 pIC50 >10000 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 3654-3661 [PMID:23642479]
CDC like kinase 4/Dual specificity protein kinase CLK4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4203] [GtoPdb: 1993] [UniProtKB: Q9HAZ1]
ChEMBL Inhibition of CLK4 (unknown origin) by bioluminescence assay B 7.3 pIC50 50 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 3654-3661 [PMID:23642479]
ChEMBL Inhibition of CLK4 (unknown origin) B 8.4 pIC50 4 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 3654-3661 [PMID:23642479]
GtoPdb - - 8.4 pIC50 4 nM IC50 Bioorg Med Chem Lett (2013) 23: 3654-61 [PMID:23642479]
dual specificity tyrosine phosphorylation regulated kinase 1A/Dual-specificity tyrosine-phosphorylation regulated kinase 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2292] [GtoPdb: 2009] [UniProtKB: Q13627]
ChEMBL Inhibition of DYRK1A (unknown origin) by bioluminescence assay B 7.3 pIC50 50 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 3654-3661 [PMID:23642479]
ChEMBL Inhibition of DYRK1A (unknown origin) B 8.4 pIC50 4 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 3654-3661 [PMID:23642479]
GtoPdb - - 8.4 pIC50 4 nM IC50 Bioorg Med Chem Lett (2013) 23: 3654-61 [PMID:23642479]
dual specificity tyrosine phosphorylation regulated kinase 1B/Dual specificity tyrosine-phosphorylation-regulated kinase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5543] [GtoPdb: 2010] [UniProtKB: Q9Y463]
GtoPdb - - 8.15 pIC50 7 nM IC50 Bioorg Med Chem Lett (2013) 23: 3654-61 [PMID:23642479]
ChEMBL Inhibition of DYRK1B (unknown origin) B 8.15 pIC50 7 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 3654-3661 [PMID:23642479]
CDC like kinase 1/Dual specificty protein kinase CLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4224] [GtoPdb: 1990] [UniProtKB: P49759]
ChEMBL Inhibition of CLK1 (unknown origin) B 8.7 pIC50 2 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 3654-3661 [PMID:23642479]
GtoPdb - - 8.7 pIC50 2 nM IC50 Bioorg Med Chem Lett (2013) 23: 3654-61 [PMID:23642479]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]