compound 33 [PMID: 19364658] [Ligand Id: 8163] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL511410
  • casein kinase 1 gamma 1/Casein kinase I gamma 1 in Human [ChEMBL: CHEMBL2426] [GtoPdb: 1999] [UniProtKB: Q9HCP0]
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  • component of inhibitor of nuclear factor kappa B kinase complex/Inhibitor of nuclear factor kappa B kinase alpha subunit in Human [ChEMBL: CHEMBL3476] [GtoPdb: 1989] [UniProtKB: O15111]
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  • MAPK activated protein kinase 2/MAP kinase-activated protein kinase 2 in Human [ChEMBL: CHEMBL2208] [GtoPdb: 2094] [UniProtKB: P49137]
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  • mitogen-activated protein kinase 1/MAP kinase ERK2 in Human [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482]
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  • mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539]
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  • platelet derived growth factor receptor alpha/Platelet-derived growth factor receptor alpha in Human [ChEMBL: CHEMBL2007] [GtoPdb: 1803] [UniProtKB: P16234]
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  • protein kinase C alpha/Protein kinase C alpha in Human [ChEMBL: CHEMBL299] [GtoPdb: 1482] [UniProtKB: P17252]
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  • Rho associated coiled-coil containing protein kinase 1/Rho-associated protein kinase 1 in Human [ChEMBL: CHEMBL3231] [GtoPdb: 1503] [UniProtKB: Q13464]
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  • ribosomal protein S6 kinase A1/Ribosomal protein S6 kinase alpha 1 in Human [ChEMBL: CHEMBL2553] [GtoPdb: 1527] [UniProtKB: Q15418]
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  • aurora kinase B/Serine/threonine-protein kinase Aurora-B in Human [ChEMBL: CHEMBL2185] [GtoPdb: 1937] [UniProtKB: Q96GD4]
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  • FYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FYN in Human [ChEMBL: CHEMBL1841] [GtoPdb: 2026] [UniProtKB: P06241]
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  • SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931]
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  • protein kinase A in Human [GtoPdb: 1694]
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  • checkpoint kinase 1 in Human [GtoPdb: 1987] [UniProtKB: O14757]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
casein kinase 1 gamma 1/Casein kinase I gamma 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2426] [GtoPdb: 1999] [UniProtKB: Q9HCP0]
ChEMBL Inhibition of CK1-gamma1 B 6.8 pIC50 160 nM IC50 Bioorg. Med. Chem. (2009) 17: 3342-3351 [PMID:19364658]
GtoPdb - - 6.8 pIC50 160 nM IC50 Bioorg Med Chem (2009) 17: 3342-51 [PMID:19364658]
component of inhibitor of nuclear factor kappa B kinase complex/Inhibitor of nuclear factor kappa B kinase alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3476] [GtoPdb: 1989] [UniProtKB: O15111]
ChEMBL Inhibition of IKKalpha B 4.3 pIC50 >50000 nM IC50 Bioorg. Med. Chem. (2009) 17: 3342-3351 [PMID:19364658]
MAPK activated protein kinase 2/MAP kinase-activated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2208] [GtoPdb: 2094] [UniProtKB: P49137]
ChEMBL Inhibition of human recombinant MK2 B 6.41 pIC50 390 nM IC50 Bioorg. Med. Chem. (2009) 17: 3342-3351 [PMID:19364658]
GtoPdb - - 6.41 pIC50 390 nM IC50 Bioorg Med Chem (2009) 17: 3342-51 [PMID:19364658]
mitogen-activated protein kinase 1/MAP kinase ERK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482]
ChEMBL Inhibition of ERK2 B 5.38 pIC50 4200 nM IC50 Bioorg. Med. Chem. (2009) 17: 3342-3351 [PMID:19364658]
mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539]
ChEMBL Inhibition of p38alpha B 4.3 pIC50 >50000 nM IC50 Bioorg. Med. Chem. (2009) 17: 3342-3351 [PMID:19364658]
platelet derived growth factor receptor alpha/Platelet-derived growth factor receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2007] [GtoPdb: 1803] [UniProtKB: P16234]
ChEMBL Inhibition of PDGFRalpha B 4.95 pIC50 11100 nM IC50 Bioorg. Med. Chem. (2009) 17: 3342-3351 [PMID:19364658]
protein kinase C alpha/Protein kinase C alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL299] [GtoPdb: 1482] [UniProtKB: P17252]
ChEMBL Inhibition of PKCalpha B 4.47 pIC50 33600 nM IC50 Bioorg. Med. Chem. (2009) 17: 3342-3351 [PMID:19364658]
Rho associated coiled-coil containing protein kinase 1/Rho-associated protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3231] [GtoPdb: 1503] [UniProtKB: Q13464]
GtoPdb - - 7.22 pIC50 60 nM IC50 Bioorg Med Chem (2009) 17: 3342-51 [PMID:19364658]
ChEMBL Inhibition of ROCK1 B 7.22 pIC50 60 nM IC50 Bioorg. Med. Chem. (2009) 17: 3342-3351 [PMID:19364658]
ribosomal protein S6 kinase A1/Ribosomal protein S6 kinase alpha 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2553] [GtoPdb: 1527] [UniProtKB: Q15418]
ChEMBL Inhibition of RSK1 B 6.54 pIC50 290 nM IC50 Bioorg. Med. Chem. (2009) 17: 3342-3351 [PMID:19364658]
GtoPdb - - 6.54 pIC50 290 nM IC50 Bioorg Med Chem (2009) 17: 3342-51 [PMID:19364658]
aurora kinase B/Serine/threonine-protein kinase Aurora-B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2185] [GtoPdb: 1937] [UniProtKB: Q96GD4]
ChEMBL Inhibition of Aurora B B 5.85 pIC50 1400 nM IC50 Bioorg. Med. Chem. (2009) 17: 3342-3351 [PMID:19364658]
FYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FYN in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1841] [GtoPdb: 2026] [UniProtKB: P06241]
ChEMBL Inhibition of FYN B 4.3 pIC50 >50000 nM IC50 Bioorg. Med. Chem. (2009) 17: 3342-3351 [PMID:19364658]
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931]
ChEMBL Inhibition of SRC B 4.3 pIC50 >50000 nM IC50 Bioorg. Med. Chem. (2009) 17: 3342-3351 [PMID:19364658]
protein kinase A in Human [GtoPdb: 1694]
GtoPdb - - 6.57 pIC50 270 nM IC50 Bioorg Med Chem (2009) 17: 3342-51 [PMID:19364658]
checkpoint kinase 1 in Human [GtoPdb: 1987] [UniProtKB: O14757]
GtoPdb - - 7.05 pIC50 90 nM IC50 Bioorg Med Chem (2009) 17: 3342-51 [PMID:19364658]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]