compound 33 [PMID: 19364658] | Ligand Activity Charts

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compound 33 [PMID: 19364658]
Ligand Activity Charts

compound 33 [PMID: 19364658] [Ligand Id: 8163] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL511410
casein kinase 1 gamma 1/Casein kinase I gamma 1 in Human [ChEMBL: CHEMBL2426] [GtoPdb: 1999] [UniProtKB: Q9HCP0] There should be some charts here, you may need to enable JavaScript!
component of inhibitor of nuclear factor kappa B kinase complex/Inhibitor of nuclear factor kappa B kinase alpha subunit in Human [ChEMBL: CHEMBL3476] [GtoPdb: 1989] [UniProtKB: O15111] There should be some charts here, you may need to enable JavaScript!
MAPK activated protein kinase 2/MAP kinase-activated protein kinase 2 in Human [ChEMBL: CHEMBL2208] [GtoPdb: 2094] [UniProtKB: P49137] There should be some charts here, you may need to enable JavaScript!
mitogen-activated protein kinase 1/MAP kinase ERK2 in Human [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482] There should be some charts here, you may need to enable JavaScript!
mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539] There should be some charts here, you may need to enable JavaScript!
platelet derived growth factor receptor alpha/Platelet-derived growth factor receptor alpha in Human [ChEMBL: CHEMBL2007] [GtoPdb: 1803] [UniProtKB: P16234] There should be some charts here, you may need to enable JavaScript!
protein kinase C alpha/Protein kinase C alpha in Human [ChEMBL: CHEMBL299] [GtoPdb: 1482] [UniProtKB: P17252] There should be some charts here, you may need to enable JavaScript!
Rho associated coiled-coil containing protein kinase 1/Rho-associated protein kinase 1 in Human [ChEMBL: CHEMBL3231] [GtoPdb: 1503] [UniProtKB: Q13464] There should be some charts here, you may need to enable JavaScript!
ribosomal protein S6 kinase A1/Ribosomal protein S6 kinase alpha 1 in Human [ChEMBL: CHEMBL2553] [GtoPdb: 1527] [UniProtKB: Q15418] There should be some charts here, you may need to enable JavaScript!
aurora kinase B/Serine/threonine-protein kinase Aurora-B in Human [ChEMBL: CHEMBL2185] [GtoPdb: 1937] [UniProtKB: Q96GD4] There should be some charts here, you may need to enable JavaScript!
FYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FYN in Human [ChEMBL: CHEMBL1841] [GtoPdb: 2026] [UniProtKB: P06241] There should be some charts here, you may need to enable JavaScript!
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931] There should be some charts here, you may need to enable JavaScript!
protein kinase A in Human [GtoPdb: 1694] There should be some charts here, you may need to enable JavaScript!
checkpoint kinase 1 in Human [GtoPdb: 1987] [UniProtKB: O14757] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
casein kinase 1 gamma 1/Casein kinase I gamma 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2426] [GtoPdb: 1999] [UniProtKB: Q9HCP0]
ChEMBL	Inhibition of CK1-gamma1	B	6.8	pIC50	160	nM	IC50	Bioorg Med Chem (2009) 17: 3342-3351 [PMID:19364658]
GtoPdb	-	-	6.8	pIC50	160	nM	IC50	Bioorg Med Chem (2009) 17: 3342-51 [PMID:19364658]
component of inhibitor of nuclear factor kappa B kinase complex/Inhibitor of nuclear factor kappa B kinase alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3476] [GtoPdb: 1989] [UniProtKB: O15111]
ChEMBL	Inhibition of IKKalpha	B	4.3	pIC50	>50000	nM	IC50	Bioorg Med Chem (2009) 17: 3342-3351 [PMID:19364658]
MAPK activated protein kinase 2/MAP kinase-activated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2208] [GtoPdb: 2094] [UniProtKB: P49137]
ChEMBL	Inhibition of human recombinant MK2	B	6.41	pIC50	390	nM	IC50	Bioorg Med Chem (2009) 17: 3342-3351 [PMID:19364658]
GtoPdb	-	-	6.41	pIC50	390	nM	IC50	Bioorg Med Chem (2009) 17: 3342-51 [PMID:19364658]
mitogen-activated protein kinase 1/MAP kinase ERK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482]
ChEMBL	Inhibition of ERK2	B	5.38	pIC50	4200	nM	IC50	Bioorg Med Chem (2009) 17: 3342-3351 [PMID:19364658]
mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539]
ChEMBL	Inhibition of p38alpha	B	4.3	pIC50	>50000	nM	IC50	Bioorg Med Chem (2009) 17: 3342-3351 [PMID:19364658]
platelet derived growth factor receptor alpha/Platelet-derived growth factor receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2007] [GtoPdb: 1803] [UniProtKB: P16234]
ChEMBL	Inhibition of PDGFRalpha	B	4.95	pIC50	11100	nM	IC50	Bioorg Med Chem (2009) 17: 3342-3351 [PMID:19364658]
protein kinase C alpha/Protein kinase C alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL299] [GtoPdb: 1482] [UniProtKB: P17252]
ChEMBL	Inhibition of PKCalpha	B	4.47	pIC50	33600	nM	IC50	Bioorg Med Chem (2009) 17: 3342-3351 [PMID:19364658]
Rho associated coiled-coil containing protein kinase 1/Rho-associated protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3231] [GtoPdb: 1503] [UniProtKB: Q13464]
GtoPdb	-	-	7.22	pIC50	60	nM	IC50	Bioorg Med Chem (2009) 17: 3342-51 [PMID:19364658]
ChEMBL	Inhibition of ROCK1	B	7.22	pIC50	60	nM	IC50	Bioorg Med Chem (2009) 17: 3342-3351 [PMID:19364658]
ribosomal protein S6 kinase A1/Ribosomal protein S6 kinase alpha 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2553] [GtoPdb: 1527] [UniProtKB: Q15418]
ChEMBL	Inhibition of RSK1	B	6.54	pIC50	290	nM	IC50	Bioorg Med Chem (2009) 17: 3342-3351 [PMID:19364658]
GtoPdb	-	-	6.54	pIC50	290	nM	IC50	Bioorg Med Chem (2009) 17: 3342-51 [PMID:19364658]
aurora kinase B/Serine/threonine-protein kinase Aurora-B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2185] [GtoPdb: 1937] [UniProtKB: Q96GD4]
ChEMBL	Inhibition of Aurora B	B	5.85	pIC50	1400	nM	IC50	Bioorg Med Chem (2009) 17: 3342-3351 [PMID:19364658]
FYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FYN in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1841] [GtoPdb: 2026] [UniProtKB: P06241]
ChEMBL	Inhibition of FYN	B	4.3	pIC50	>50000	nM	IC50	Bioorg Med Chem (2009) 17: 3342-3351 [PMID:19364658]
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931]
ChEMBL	Inhibition of SRC	B	4.3	pIC50	>50000	nM	IC50	Bioorg Med Chem (2009) 17: 3342-3351 [PMID:19364658]
protein kinase A in Human [GtoPdb: 1694]
GtoPdb	-	-	6.57	pIC50	270	nM	IC50	Bioorg Med Chem (2009) 17: 3342-51 [PMID:19364658]
checkpoint kinase 1 in Human [GtoPdb: 1987] [UniProtKB: O14757]
GtoPdb	-	-	7.05	pIC50	90	nM	IC50	Bioorg Med Chem (2009) 17: 3342-51 [PMID:19364658]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]