compound 35 [PMID: 20684608] [Ligand Id: 8209] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1215304
  • mitogen-activated protein kinase 10/c-Jun N-terminal kinase 3 in Human [ChEMBL: CHEMBL2637] [GtoPdb: 1498] [UniProtKB: P53779]
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  • Rho associated coiled-coil containing protein kinase 1/Rho-associated protein kinase 1 in Human [ChEMBL: CHEMBL3231] [GtoPdb: 1503] [UniProtKB: Q13464]
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  • Rho associated coiled-coil containing protein kinase 2/Rho-associated protein kinase 2 in Human [ChEMBL: CHEMBL2973] [GtoPdb: 1504] [UniProtKB: O75116]
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  • CDC42 binding protein kinase alpha/Serine/threonine-protein kinase MRCK-A in Human [ChEMBL: CHEMBL4516] [GtoPdb: 1507] [UniProtKB: Q5VT25]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
mitogen-activated protein kinase 10/c-Jun N-terminal kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2637] [GtoPdb: 1498] [UniProtKB: P53779]
ChEMBL Inhibition of JNK3 B 4.7 pIC50 >20000 nM IC50 J. Med. Chem. (2010) 53: 5727-5737 [PMID:20684608]
Rho associated coiled-coil containing protein kinase 1/Rho-associated protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3231] [GtoPdb: 1503] [UniProtKB: Q13464]
GtoPdb - - 8 pIC50 10 nM IC50 J. Med. Chem. (2010) 53: 5727-37 [PMID:20684608]
ChEMBL Inhibition of ROCK1 B 8 pIC50 10 nM IC50 J. Med. Chem. (2010) 53: 5727-5737 [PMID:20684608]
Rho associated coiled-coil containing protein kinase 2/Rho-associated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2973] [GtoPdb: 1504] [UniProtKB: O75116]
ChEMBL Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assay B 7.29 pIC50 51 nM IC50 J. Med. Chem. (2010) 53: 5727-5737 [PMID:20684608]
GtoPdb - - 9 pIC50 <1 nM IC50 J. Med. Chem. (2010) 53: 5727-37 [PMID:20684608]
ChEMBL Inhibition of ROCK2 B 9 pIC50 <1 nM IC50 J. Med. Chem. (2010) 53: 5727-5737 [PMID:20684608]
CDC42 binding protein kinase alpha/Serine/threonine-protein kinase MRCK-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4516] [GtoPdb: 1507] [UniProtKB: Q5VT25]
ChEMBL Inhibition of MRCKalpha B 6.17 pIC50 669 nM IC50 J. Med. Chem. (2010) 53: 5727-5737 [PMID:20684608]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]