CXCL8 [Ligand Id: 821] activity data from GtoPdb

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  • CXCR1 in Human [GtoPdb: 68] [UniProtKB: P25024]
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  • CXCR2 in Human [GtoPdb: 69] [UniProtKB: P25025]
  • CXCR2 in Mouse [GtoPdb: 69] [UniProtKB: P35343]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
CXCR1 in Human [GtoPdb: 68] [UniProtKB: P25024]
GtoPdb - - 8.1 pKd 8 nM Kd Blood (2012) 119: 2274-83 [PMID:22262769]
GtoPdb - - 9.5 pKi - - - J. Biol. Chem. (1992) 267: 16283-7 [PMID:1379593];
Br. J. Pharmacol. (1999) 126: 810-8 [PMID:10188995];
J. Biol. Chem. (2005) 280: 28663-74 [PMID:15946947];
J. Biol. Chem. (1996) 271: 31202-9 [PMID:8940121];
Proc. Natl. Acad. Sci. U.S.A. (2004) 101: 11791-6 [PMID:15282370]
CXCR2 in Human [GtoPdb: 69] [UniProtKB: P25025]
GtoPdb - - 9.5 pKi - - - J. Biol. Chem. (1992) 267: 16283-7 [PMID:1379593];
Br. J. Pharmacol. (1999) 126: 810-8 [PMID:10188995];
J. Biol. Chem. (2005) 280: 28663-74 [PMID:15946947];
J. Biol. Chem. (1996) 271: 31202-9 [PMID:8940121];
Proc. Natl. Acad. Sci. U.S.A. (2004) 101: 11791-6 [PMID:15282370]
CXCR2 in Mouse [GtoPdb: 69] [UniProtKB: P35343]
GtoPdb - - 6.4 pKi - - - J. Biol. Chem. (1994) 269: 29355-8 [PMID:7961909]

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.