ChEMBL ligand: CHEMBL146927
Gamma-amino-N-butyrate transaminase in Pig [ChEMBL: CHEMBL2266] [UniProtKB: P80147] There should be some charts here, you may need to enable JavaScript!
4-aminobutyrate aminotransferase in Human [GtoPdb: 2464] [UniProtKB: P80404] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Gamma-amino-N-butyrate transaminase in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2266] [UniProtKB: P80147]
ChEMBL	Binding affinity pig brain GABA-AT assessed as inactivation constant using GABA as substrate in presence of NADP+ and alpha-ketoglutarate by SSDH coupled enzyme based UV-Vis spectrophotometry	B	4.23	pKi	59000	nM	Ki	ACS Med Chem Lett (2020) 11: 1949-1955 [PMID:33062178]
ChEMBL	Tested for inhibitory activity against gamma-aminobutyric acid aminotransferase from pig brain	B	4.51	pKi	31000	nM	Ki	J Med Chem (2003) 46: 5292-5293 [PMID:14640537]
4-aminobutyrate aminotransferase in Human [GtoPdb: 2464] [UniProtKB: P80404]
GtoPdb	-	-	5.01	pKi	9700	nM	Ki	J Med Chem (2012) 55: 567-75 [PMID:22168767]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]