ChEMBL ligand: CHEMBL146927
Gamma-amino-N-butyrate transaminase in Pig [ChEMBL: CHEMBL2266] [UniProtKB: P80147] There should be some charts here, you may need to enable JavaScript!
4-aminobutyrate aminotransferase in Human [GtoPdb: 2464] [UniProtKB: P80404] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Gamma-amino-N-butyrate transaminase in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2266] [UniProtKB: P80147]
ChEMBL	Binding affinity pig brain GABA-AT assessed as inactivation constant using GABA as substrate in presence of NADP+ and alpha-ketoglutarate by SSDH coupled enzyme based UV-Vis spectrophotometry	B	4.23	pKi	59000	nM	Ki	ACS Med Chem Lett (2020) 11: 1949-1955 [PMID:33062178]
ChEMBL	Tested for inhibitory activity against gamma-aminobutyric acid aminotransferase from pig brain	B	4.51	pKi	31000	nM	Ki	J Med Chem (2003) 46: 5292-5293 [PMID:14640537]
4-aminobutyrate aminotransferase in Human [GtoPdb: 2464] [UniProtKB: P80404]
GtoPdb	-	-	5.01	pKi	9700	nM	Ki	J Med Chem (2012) 55: 567-75 [PMID:22168767]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]