AAE-M-PBP-amine [Ligand Id: 8289] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3260987 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| MT1 receptor/Melatonin receptor 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1945] [GtoPdb: 287] [UniProtKB: P48039] | ||||||||
| GtoPdb | - | - | 8.9 | pKi | - | - | - | ChemMedChem (2012) 7: 1954-64 [PMID:22927210] |
| ChEMBL | Agonist activity at MT1 receptor (unknown origin) expressed in mouse NIH3T3 cells assessed as inhibition of forskolin-induced cAMP accumulation | F | 8.93 | pKi | 1.17 | nM | Ki | J Med Chem (2014) 57: 3161-3185 [PMID:24228714] |
| ChEMBL | Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in rat NIH3T3 cells after 90 mins | B | 8.93 | pKi | 1.17 | nM | Ki | Medchemcomm (2015) 6: 1340-1344 |
| MT2 receptor/Melatonin receptor 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1946] [GtoPdb: 288] [UniProtKB: P49286] | ||||||||
| ChEMBL | Agonist activity at MT2 receptor (unknown origin) expressed in mouse NIH3T3 cells assessed as inhibition of forskolin-induced cAMP accumulation | F | 7.04 | pKi | 91.2 | nM | Ki | J Med Chem (2014) 57: 3161-3185 [PMID:24228714] |
| ChEMBL | Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in rat NIH3T3 cells after 90 mins | B | 7.04 | pKi | 91 | nM | Ki | Medchemcomm (2015) 6: 1340-1344 |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
