ML321 [Ligand Id: 8368] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL3234544
  • D2 receptor/Dopamine D2 receptor in Human [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
1 CHEMBL3234544_lig_chart_1 Dopamine D2 receptor Human
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  • D3 receptor/Dopamine D3 receptor in Human [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462]
  • This target only has 1 pki data point
2 CHEMBL3234544_lig_chart_2 Dopamine D3 receptor Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
GtoPdb - - 7 pKi 100 nM Ki J. Med. Chem. (2014) 57: 3450-63 [PMID:24666157];
Probe Reports from the NIH Molecular Libraries Program (2010) : [PMID:24260782]
ChEMBL Displacement of [3H]methylspiperone from human D2L receptor expressed in HEK cell membrane after 90 mins by scintillation counting analysis B 7 pKi 100 nM Ki J. Med. Chem. (2014) 57: 3450-3463 [PMID:24666157]
D3 receptor/Dopamine D3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462]
ChEMBL Displacement of [3H]methylspiperone from human D3 receptor expressed in HEK293 cell membrane after 90 mins by scintillation counting analysis B 5.39 pKi 4100 nM Ki J. Med. Chem. (2014) 57: 3450-3463 [PMID:24666157]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]