VS-5584 [Ligand Id: 8382] activity data from GtoPdb

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  • mechanistic target of rapamycin kinase in Human [GtoPdb: 2109] [UniProtKB: P42345]
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  • phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha in Human [GtoPdb: 2153] [UniProtKB: P42336]
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  • phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta in Human [GtoPdb: 2154] [UniProtKB: P42338]
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  • phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta in Human [GtoPdb: 2155] [UniProtKB: O00329]
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  • phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma in Human [GtoPdb: 2156] [UniProtKB: P48736]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
mechanistic target of rapamycin kinase in Human [GtoPdb: 2109] [UniProtKB: P42345]
GtoPdb - - 7.43 pIC50 37 nM IC50 Mol. Cancer Ther. (2013) 12: 151-61 [PMID:23270925]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha in Human [GtoPdb: 2153] [UniProtKB: P42336]
GtoPdb - - 7.8 pIC50 16 nM IC50 Mol. Cancer Ther. (2013) 12: 151-61 [PMID:23270925]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta in Human [GtoPdb: 2154] [UniProtKB: P42338]
GtoPdb - - 7.17 pIC50 68 nM IC50 Mol. Cancer Ther. (2013) 12: 151-61 [PMID:23270925]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta in Human [GtoPdb: 2155] [UniProtKB: O00329]
GtoPdb - - 7.38 pIC50 42 nM IC50 Mol. Cancer Ther. (2013) 12: 151-61 [PMID:23270925]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma in Human [GtoPdb: 2156] [UniProtKB: P48736]
GtoPdb - - 7.6 pIC50 25 nM IC50 Mol. Cancer Ther. (2013) 12: 151-61 [PMID:23270925]

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.