retosiban [Ligand Id: 8403] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL429736 (GSK-221149, GSK221149, GSK-221149A, GSK221149A, Retosiban) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| OT receptor/Oxytocin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2049] [GtoPdb: 369] [UniProtKB: P30559] | ||||||||
| ChEMBL | Binding affinity to recombinant oxytocin receptor | B | 8.39 | pKi | 4.1 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 90-94 [PMID:18032036] |
| ChEMBL | Binding affinity to human oxytocin receptor | B | 9 | pKi | 1 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 90-94 [PMID:18032036] |
| ChEMBL | Binding affinity to human oxytocin receptor | B | 9.19 | pKi | 0.65 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 90-94 [PMID:18032036] |
| GtoPdb | - | - | 9.19 | pKi | 0.65 | nM | Ki |
Am J Physiol Regul Integr Comp Physiol (2007) 293: R299-305 [PMID:17395790]; Bioorg Med Chem Lett (2008) 18: 90-4 [PMID:18032036] |
| ChEMBL | Displacement of [3H]-oxytocin from oxytocin receptor in human uterus tissue | B | 9.2 | pKi | 0.63 | nM | Ki | J Med Chem (2010) 53: 6525-6538 [PMID:20550119] |
| V1A receptor/Vasopressin V1a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1889] [GtoPdb: 366] [UniProtKB: P37288] | ||||||||
| ChEMBL | Binding affinity to human vasopressin V1a receptor | B | 4.92 | pKi | >12000 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 90-94 [PMID:18032036] |
| V1B receptor/Vasopressin V1b receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1921] [GtoPdb: 367] [UniProtKB: P47901] | ||||||||
| ChEMBL | Binding affinity to human vasopressin V1b receptor | B | 5 | pKi | >10000 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 90-94 [PMID:18032036] |
| V2 receptor/Vasopressin V2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1790] [GtoPdb: 368] [UniProtKB: P30518] | ||||||||
| ChEMBL | Binding affinity to human vasopressin V2 receptor | B | 6.02 | pKi | 950 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 90-94 [PMID:18032036] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
