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ChEMBL ligand: CHEMBL429736 (GSK221149, GSK-221149, GSK221149A, GSK-221149A, Retosiban) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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OT receptor/Oxytocin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2049] [GtoPdb: 369] [UniProtKB: P30559] | ||||||||
ChEMBL | Binding affinity to recombinant oxytocin receptor | B | 8.39 | pKi | 4.1 | nM | Ki | Bioorg. Med. Chem. Lett. (2008) 18: 90-94 [PMID:18032036] |
ChEMBL | Binding affinity to human oxytocin receptor | B | 9 | pKi | 1 | nM | Ki | Bioorg. Med. Chem. Lett. (2008) 18: 90-94 [PMID:18032036] |
ChEMBL | Binding affinity to human oxytocin receptor | B | 9.19 | pKi | 0.65 | nM | Ki | Bioorg. Med. Chem. Lett. (2008) 18: 90-94 [PMID:18032036] |
GtoPdb | - | - | 9.19 | pKi | 0.65 | nM | Ki |
Am J Physiol Regul Integr Comp Physiol (2007) 293: R299-305 [PMID:17395790]; Bioorg Med Chem Lett (2008) 18: 90-4 [PMID:18032036] |
ChEMBL | Displacement of [3H]-oxytocin from oxytocin receptor in human uterus tissue | B | 9.2 | pKi | 0.63 | nM | Ki | J. Med. Chem. (2010) 53: 6525-6538 [PMID:20550119] |
V1A receptor/Vasopressin V1a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1889] [GtoPdb: 366] [UniProtKB: P37288] | ||||||||
ChEMBL | Binding affinity to human vasopressin V1a receptor | B | 4.92 | pKi | >12000 | nM | Ki | Bioorg. Med. Chem. Lett. (2008) 18: 90-94 [PMID:18032036] |
V1B receptor/Vasopressin V1b receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1921] [GtoPdb: 367] [UniProtKB: P47901] | ||||||||
ChEMBL | Binding affinity to human vasopressin V1b receptor | B | 5 | pKi | >10000 | nM | Ki | Bioorg. Med. Chem. Lett. (2008) 18: 90-94 [PMID:18032036] |
V2 receptor/Vasopressin V2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1790] [GtoPdb: 368] [UniProtKB: P30518] | ||||||||
ChEMBL | Binding affinity to human vasopressin V2 receptor | B | 6.02 | pKi | 950 | nM | Ki | Bioorg. Med. Chem. Lett. (2008) 18: 90-94 [PMID:18032036] |
ChEMBL data shown on this page come from version 31:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]