SKF-83959 [Ligand Id: 8443] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL574558
  • D1 receptor/Dopamine D1 receptor in Human [ChEMBL: CHEMBL2056] [GtoPdb: 214] [UniProtKB: P21728]
1 CHEMBL574558_lig_chart_1 Dopamine D1 receptor Human
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  • 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
  • This target only has 1 pki data point
2 CHEMBL574558_lig_chart_2 Serotonin 1a (5-HT1a) receptor Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
D1 receptor/Dopamine D1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2056] [GtoPdb: 214] [UniProtKB: P21728]
ChEMBL Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting B 8.71 pKi 1.93 nM Ki Bioorg. Med. Chem. (2009) 17: 4873-4880 [PMID:19559623]
ChEMBL Agonist activity at dopamine D1 receptor F 8.93 pKi 1.18 nM Ki Bioorg. Med. Chem. (2009) 17: 4873-4880 [PMID:19559623]
GtoPdb Biased towards G-protein signalling in a cellular assay expressing only D1 receptor. - 9.7 pEC50 0.2 nM EC50 ACS Chem Neurosci (2015) 6: 681-92 [PMID:25660762]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
ChEMBL Displacement of [3H]8-OH-DPAT from 5HT1A receptor expressed in CHO cells by liquid scintillation counting B 6 pKi >1000 nM Ki Bioorg. Med. Chem. (2009) 17: 4873-4880 [PMID:19559623]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]