AZD5438 [Ligand Id: 8473] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL488436 (AZD-5438)
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  • cyclin dependent kinase 1/Cyclin-dependent kinase 1 in Human [ChEMBL: CHEMBL308] [GtoPdb: 1961] [UniProtKB: P06493]
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  • cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941]
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  • cyclin dependent kinase 4/Cyclin-dependent kinase 4 in Human [ChEMBL: CHEMBL331] [GtoPdb: 1976] [UniProtKB: P11802]
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  • G2/mitotic-specific cyclin B1 in Human [ChEMBL: CHEMBL2412] [UniProtKB: P14635]
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  • cyclin dependent kinase 9 in Human [GtoPdb: 1981] [UniProtKB: P50750]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Cyclin A2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2582] [UniProtKB: P20248]
ChEMBL Inhibition of Cyclin A/CDK2 B 7.35 pIC50 45 nM IC50 Bioorg. Med. Chem. Lett. (2008) 18: 5487-5492 [PMID:18815031]
cyclin dependent kinase 1/Cyclin-dependent kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL308] [GtoPdb: 1961] [UniProtKB: P06493]
ChEMBL Inhibition of CDK1 B 7.21 pIC50 62 nM IC50 Bioorg. Med. Chem. Lett. (2008) 18: 6369-6373 [PMID:18996007]
GtoPdb CDK1/cyclin B1 complex. - 7.8 pIC50 16 nM IC50 Mol. Cancer Ther. (2009) 8: 1856-66 [PMID:19509270]
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941]
GtoPdb CDK2/cyclin E complex. - 8.22 pIC50 6 nM IC50 Mol. Cancer Ther. (2009) 8: 1856-66 [PMID:19509270]
ChEMBL Inhibition of CDK2 B 8.22 pIC50 6 nM IC50 Bioorg. Med. Chem. Lett. (2008) 18: 5487-5492 [PMID:18815031]
ChEMBL Inhibition of CDK2 B 8.22 pIC50 <6 nM IC50 Bioorg. Med. Chem. Lett. (2008) 18: 6486-6489 [PMID:18986805]
ChEMBL Inhibition of CDK2 B 8.22 pIC50 6 nM IC50 Bioorg. Med. Chem. Lett. (2008) 18: 6369-6373 [PMID:18996007]
cyclin dependent kinase 4/Cyclin-dependent kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL331] [GtoPdb: 1976] [UniProtKB: P11802]
ChEMBL Inhibition of CDK4 B 6.35 pIC50 450 nM IC50 Bioorg. Med. Chem. Lett. (2008) 18: 5487-5492 [PMID:18815031]
Cyclin T1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2108] [UniProtKB: O60563]
ChEMBL Inhibition of Cyclin T/CDK9 B 7.7 pIC50 20 nM IC50 Bioorg. Med. Chem. Lett. (2008) 18: 5487-5492 [PMID:18815031]
G1/S-specific cyclin D3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2422] [UniProtKB: P30281]
ChEMBL Inhibition of Cyclin D3/CDK6 B 7.68 pIC50 21 nM IC50 Bioorg. Med. Chem. Lett. (2008) 18: 5487-5492 [PMID:18815031]
G1/S-specific cyclin E1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3617] [UniProtKB: P24864]
ChEMBL Inhibition of Cyclin E/CDK2 B 8.22 pIC50 6 nM IC50 Bioorg. Med. Chem. Lett. (2008) 18: 5487-5492 [PMID:18815031]
G2/mitotic-specific cyclin B1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2412] [UniProtKB: P14635]
ChEMBL Inhibition of Cyclin B1/CDK1 B 7.8 pIC50 16 nM IC50 Bioorg. Med. Chem. Lett. (2008) 18: 5487-5492 [PMID:18815031]
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL Inhibition of human ERG by patch clamp assay B 5.49 pIC50 3200 nM IC50 Bioorg. Med. Chem. Lett. (2008) 18: 6486-6489 [PMID:18986805]
cyclin dependent kinase 9 in Human [GtoPdb: 1981] [UniProtKB: P50750]
GtoPdb CDK9/cyclin T complex. - 7.7 pIC50 20 nM IC50 Mol. Cancer Ther. (2009) 8: 1856-66 [PMID:19509270]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]