compound 22e [PMID: 20167483] [Ligand Id: 8504] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1089721 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| BB3 receptor/Bombesin receptor subtype-3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4080] [GtoPdb: 40] [UniProtKB: P32247] | ||||||||
| GtoPdb | - | - | 7.6 | pIC50 | 25 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 1913-7 [PMID:20167483] |
| ChEMBL | Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation counting | B | 7.96 | pIC50 | 11 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 2074-2077 [PMID:20219372] |
| ChEMBL | Binding affinity to human BRS3 | B | 7.96 | pIC50 | 11 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 2912-2915 [PMID:20347296] |
| ChEMBL | Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin | F | 7 | pEC50 | 101 | nM | EC50 | Bioorg Med Chem Lett (2010) 20: 2074-2077 [PMID:20219372] |
| ChEMBL | Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay | F | 7.6 | pEC50 | 25 | nM | EC50 | Bioorg Med Chem Lett (2010) 20: 1913-1917 [PMID:20167483] |
| ChEMBL | Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay | F | 7.6 | pEC50 | 25 | nM | EC50 | Bioorg Med Chem Lett (2010) 20: 2074-2077 [PMID:20219372] |
| ChEMBL | Agonist activity at human BRS3 | F | 7.6 | pEC50 | 25 | nM | EC50 | Bioorg Med Chem Lett (2010) 20: 2912-2915 [PMID:20347296] |
| BB3 receptor/Bombesin receptor subtype-3 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075140] [GtoPdb: 40] [UniProtKB: O54798] | ||||||||
| ChEMBL | Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin | F | 7.03 | pEC50 | 94 | nM | EC50 | Bioorg Med Chem Lett (2010) 20: 2074-2077 [PMID:20219372] |
| ChEMBL | Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay | F | 8.02 | pEC50 | 9.6 | nM | EC50 | Bioorg Med Chem Lett (2010) 20: 1913-1917 [PMID:20167483] |
| ChEMBL | Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay | F | 8.02 | pEC50 | 9.6 | nM | EC50 | Bioorg Med Chem Lett (2010) 20: 2074-2077 [PMID:20219372] |
| ChEMBL | Agonist activity at mouse BRS3 | F | 8.02 | pEC50 | 9.6 | nM | EC50 | Bioorg Med Chem Lett (2010) 20: 2912-2915 [PMID:20347296] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
