compound 22e [PMID: 20167483] [Ligand Id: 8504] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1089721
  • BB3 receptor/Bombesin receptor subtype-3 in Human [ChEMBL: CHEMBL4080] [GtoPdb: 40] [UniProtKB: P32247]
  • BB3 receptor/Bombesin receptor subtype-3 in Mouse [ChEMBL: CHEMBL1075140] [GtoPdb: 40] [UniProtKB: O54798]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
BB3 receptor/Bombesin receptor subtype-3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4080] [GtoPdb: 40] [UniProtKB: P32247]
GtoPdb - - 7.6 pIC50 25 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 1913-7 [PMID:20167483]
ChEMBL Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation counting B 7.96 pIC50 11 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 2074-2077 [PMID:20219372]
ChEMBL Binding affinity to human BRS3 B 7.96 pIC50 11 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 2912-2915 [PMID:20347296]
ChEMBL Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin F 7 pEC50 101 nM EC50 Bioorg. Med. Chem. Lett. (2010) 20: 2074-2077 [PMID:20219372]
ChEMBL Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay F 7.6 pEC50 25 nM EC50 Bioorg. Med. Chem. Lett. (2010) 20: 1913-1917 [PMID:20167483]
ChEMBL Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay F 7.6 pEC50 25 nM EC50 Bioorg. Med. Chem. Lett. (2010) 20: 2074-2077 [PMID:20219372]
ChEMBL Agonist activity at human BRS3 F 7.6 pEC50 25 nM EC50 Bioorg. Med. Chem. Lett. (2010) 20: 2912-2915 [PMID:20347296]
BB3 receptor/Bombesin receptor subtype-3 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075140] [GtoPdb: 40] [UniProtKB: O54798]
ChEMBL Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin F 7.03 pEC50 94 nM EC50 Bioorg. Med. Chem. Lett. (2010) 20: 2074-2077 [PMID:20219372]
ChEMBL Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay F 8.02 pEC50 9.6 nM EC50 Bioorg. Med. Chem. Lett. (2010) 20: 1913-1917 [PMID:20167483]
ChEMBL Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay F 8.02 pEC50 9.6 nM EC50 Bioorg. Med. Chem. Lett. (2010) 20: 2074-2077 [PMID:20219372]
ChEMBL Agonist activity at mouse BRS3 F 8.02 pEC50 9.6 nM EC50 Bioorg. Med. Chem. Lett. (2010) 20: 2912-2915 [PMID:20347296]

ChEMBL data shown on this page come from version 25:

A.P. Bento, A. Gaulton, A. Hersey, et al. (2014). The ChEMBL bioactivity database: an update. Nucl. Acids Res. Database Issue. 42 D1083-D1090. [PMID:24214965]