compound 22e [PMID: 20167483] [Ligand Id: 8504] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1089721 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| BB3 receptor/Bombesin receptor subtype-3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4080] [GtoPdb: 40] [UniProtKB: P32247] | ||||||||
| GtoPdb | - | - | 7.6 | pIC50 | 25 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 1913-7 [PMID:20167483] |
| ChEMBL | Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation counting | B | 7.96 | pIC50 | 11 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 2074-2077 [PMID:20219372] |
| ChEMBL | Binding affinity to human BRS3 | B | 7.96 | pIC50 | 11 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 2912-2915 [PMID:20347296] |
| ChEMBL | Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin | F | 7 | pEC50 | 101 | nM | EC50 | Bioorg Med Chem Lett (2010) 20: 2074-2077 [PMID:20219372] |
| ChEMBL | Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay | F | 7.6 | pEC50 | 25 | nM | EC50 | Bioorg Med Chem Lett (2010) 20: 1913-1917 [PMID:20167483] |
| ChEMBL | Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay | F | 7.6 | pEC50 | 25 | nM | EC50 | Bioorg Med Chem Lett (2010) 20: 2074-2077 [PMID:20219372] |
| ChEMBL | Agonist activity at human BRS3 | F | 7.6 | pEC50 | 25 | nM | EC50 | Bioorg Med Chem Lett (2010) 20: 2912-2915 [PMID:20347296] |
| BB3 receptor/Bombesin receptor subtype-3 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075140] [GtoPdb: 40] [UniProtKB: O54798] | ||||||||
| ChEMBL | Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin | F | 7.03 | pEC50 | 94 | nM | EC50 | Bioorg Med Chem Lett (2010) 20: 2074-2077 [PMID:20219372] |
| ChEMBL | Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay | F | 8.02 | pEC50 | 9.6 | nM | EC50 | Bioorg Med Chem Lett (2010) 20: 1913-1917 [PMID:20167483] |
| ChEMBL | Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay | F | 8.02 | pEC50 | 9.6 | nM | EC50 | Bioorg Med Chem Lett (2010) 20: 2074-2077 [PMID:20219372] |
| ChEMBL | Agonist activity at mouse BRS3 | F | 8.02 | pEC50 | 9.6 | nM | EC50 | Bioorg Med Chem Lett (2010) 20: 2912-2915 [PMID:20347296] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
