compound 3 [PMID: 17942791] [Ligand Id: 8556] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1979298
  • Ras converting CAAX endopeptidase 1/Prenyl protein specific protease in Human [ChEMBL: CHEMBL3411] [GtoPdb: 2412] [UniProtKB: Q9Y256]
  • This target only has 0 pki data point
  • 0
1 CHEMBL1979298_lig_chart_1 Prenyl protein specific protease Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Ras converting CAAX endopeptidase 1/Prenyl protein specific protease in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3411] [GtoPdb: 2412] [UniProtKB: Q9Y256]
GtoPdb - - 5.05 pIC50 9000 nM IC50 J Biomol Screen (2007) 12: 983-93 [PMID:17942791]
ChEMBL Inhibition of human Rce1-mediated CaaX protease activity using ABZ-KSKTKC(farnesyl)QIIM and ABZ-KSKTKC(farnesyl)VIQI as substrate assessed as residual activity measured every 30 to 60 seconds for 60 mins B 5.16 pIC50 6900 nM IC50 Bioorg. Med. Chem. (2016) 24: 160-178 [PMID:26706114]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]