JZL195 [Ligand Id: 8606] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL606201
  • Fatty acid amide hydrolase in Human [GtoPdb: 1400] [UniProtKB: O00519]
  • Fatty acid amide hydrolase/Anandamide amidohydrolase in Mouse [ChEMBL: CHEMBL3455] [GtoPdb: 1400] [UniProtKB: O08914]
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  • αβ-Hydrolase 6/Monoacylglycerol lipase ABHD6 in Mouse [ChEMBL: CHEMBL5010] [GtoPdb: 2919] [UniProtKB: Q8R2Y0]
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  • Monoacylglycerol lipase in Human [GtoPdb: 1399] [UniProtKB: Q99685]
  • Monoacylglycerol lipase/Monoglyceride lipase in Mouse [ChEMBL: CHEMBL5774] [GtoPdb: 1399] [UniProtKB: O35678]
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  • acyloxyacyl hydrolase in Human [GtoPdb: 2873] [UniProtKB: P28039]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Fatty acid amide hydrolase in Human [GtoPdb: 1400] [UniProtKB: O00519]
GtoPdb in vitro assay - 8.7 pIC50 2 nM IC50 Proc. Natl. Acad. Sci. U.S.A. (2009) 106: 20270-5 [PMID:19918051]
Fatty acid amide hydrolase/Anandamide amidohydrolase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3455] [GtoPdb: 1400] [UniProtKB: O08914]
ChEMBL Inhibition of FAAH in mouse brain membrane B 7.89 pIC50 13 nM IC50 J. Med. Chem. (2010) 53: 1830-1842 [PMID:20099888]
αβ-Hydrolase 6/Monoacylglycerol lipase ABHD6 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5010] [GtoPdb: 2919] [UniProtKB: Q8R2Y0]
ChEMBL Inhibition of ABHD6 in mouse brain membrane B 7.3 pIC50 50 nM IC50 J. Med. Chem. (2010) 53: 1830-1842 [PMID:20099888]
Monoacylglycerol lipase in Human [GtoPdb: 1399] [UniProtKB: Q99685]
GtoPdb in vitro assay - 8.4 pIC50 4 nM IC50 Proc. Natl. Acad. Sci. U.S.A. (2009) 106: 20270-5 [PMID:19918051]
Monoacylglycerol lipase/Monoglyceride lipase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5774] [GtoPdb: 1399] [UniProtKB: O35678]
ChEMBL Inhibition of MAGL in mouse brain membrane B 7.72 pIC50 19 nM IC50 J. Med. Chem. (2010) 53: 1830-1842 [PMID:20099888]
Neuropathy target esterase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3259506] [UniProtKB: Q3TRM4]
ChEMBL Inhibition of NTE in mouse brain membrane B 4.3 pIC50 >50000 nM IC50 J. Med. Chem. (2010) 53: 1830-1842 [PMID:20099888]
acyloxyacyl hydrolase in Human [GtoPdb: 2873] [UniProtKB: P28039]
GtoPdb - - 7.36 pIC50 44 nM IC50 Nat. Chem. Biol. (2014) 10: 656-63 [PMID:24997602]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]