ABL127 [Ligand Id: 8608] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1475741
  • protein phosphatase methylesterase 1/Protein phosphatase methylesterase 1 in Human [ChEMBL: CHEMBL1293320] [GtoPdb: 2875] [UniProtKB: Q9Y570]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
protein phosphatase methylesterase 1/Protein phosphatase methylesterase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293320] [GtoPdb: 2875] [UniProtKB: Q9Y570]
GtoPdb - - 7.92 pIC50 12 nM IC50 Nat Chem Biol (2014) 10: 656-63 [PMID:24997602]
ChEMBL Inhibition of PME1 binding to FP-rhodamine in human MDA-MB-231 cells after 30 mins by fluorescence polarization activity-based protein profiling assay B 8 pIC50 10 nM IC50 J. Med. Chem. (2011) 54: 5229-5236 [PMID:21639134]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]