compound 4b [PMID: 20690647] [Ligand Id: 8614] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1240873
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  • calpain 1 in Pig [GtoPdb: 2336]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Calpain 1 in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4062] [UniProtKB: P35750]
ChEMBL Inhibition of porcine erythrocyte calpain 1 B 7.64 pKi 23 nM Ki J Med Chem (2010) 53: 6326-6336 [PMID:20690647]
Calpain 2 in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4143] [UniProtKB: P43367]
ChEMBL Inhibition of porcine kidney calpain 2 B 7.11 pKi 77 nM Ki J Med Chem (2010) 53: 6326-6336 [PMID:20690647]
cathepsin B/Cathepsin B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4072] [GtoPdb: 2343] [UniProtKB: P07858]
ChEMBL Inhibition of human liver cathepsin B B 6.06 pKi 880 nM Ki J Med Chem (2010) 53: 6326-6336 [PMID:20690647]
calpain 1 in Pig [GtoPdb: 2336]
GtoPdb - - 7.64 pKi 23 nM Ki J Med Chem (2010) 53: 6326-36 [PMID:20690647]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]