compound 1b [PMID: 18078750] [Ligand Id: 8627] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL163454
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  • Carboxypeptidase A1 (pancreatic)/Carboxypeptidase A1 in Human [ChEMBL: CHEMBL2088] [GtoPdb: 1587] [UniProtKB: P15085]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Angiotensin-converting enzyme in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1808] [GtoPdb: 1613] [UniProtKB: P12821]
ChEMBL Inhibition of human recombinant ACE by fluorescence assay B 6.28 pKi 520 nM Ki Bioorg. Med. Chem. Lett. (2008) 18: 732-737 [PMID:18078750]
Angiotensin-converting enzyme 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3736] [GtoPdb: 1614] [UniProtKB: Q9BYF1]
ChEMBL Inhibition of human recombinant ACE2 by fluorescence assay B 5.85 pKi 1400 nM Ki Bioorg. Med. Chem. Lett. (2008) 18: 732-737 [PMID:18078750]
Carboxypeptidase A1 (pancreatic)/Carboxypeptidase A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2088] [GtoPdb: 1587] [UniProtKB: P15085]
ChEMBL Inhibition of human recombinant carboxy peptidase A1 by fluorescence assay B 6.51 pKi 310 nM Ki Bioorg. Med. Chem. Lett. (2008) 18: 732-737 [PMID:18078750]
GtoPdb - - 6.51 pKi 310 nM Ki Bioorg Med Chem Lett (2008) 18: 732-7 [PMID:18078750]
Neutral endopeptidase/Neprilysin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1944] [GtoPdb: 1611] [UniProtKB: P08473]
ChEMBL Inhibition of human recombinant NEP by fluorescence assay B 8.89 pKi 1.3 nM Ki Bioorg. Med. Chem. Lett. (2008) 18: 732-737 [PMID:18078750]
GtoPdb - - 8.89 pKi 1.3 nM Ki Bioorg Med Chem Lett (2008) 18: 732-7 [PMID:18078750]
Neutral endopeptidase/Neprilysin in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3369] [GtoPdb: 1611] [UniProtKB: P07861]
ChEMBL Inhibition of neutral endopeptidase (NEP) 24.11 B 7 pIC50 100 nM IC50 Bioorg. Med. Chem. Lett. (1995) 5: 735-738

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]