SL422 [Ligand Id: 8629] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL88520 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| ADAM17 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3706] [GtoPdb: 1662] [UniProtKB: P78536] | ||||||||
| ChEMBL | Inhibition of LPS-stimulated TNF-alpha release in human whole blood | F | 6.66 | pIC50 | 220 | nM | IC50 | J Med Chem (2001) 44: 2636-2660 [PMID:11472217] |
| ADAM17 in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3332] [UniProtKB: O77636] | ||||||||
| ChEMBL | Inhibition of porcine TNF-alpha converting enzyme (pTACE). | B | 7.92 | pKi | 12 | nM | Ki | J Med Chem (2001) 44: 2636-2660 [PMID:11472217] |
| MMP1/Matrix metalloproteinase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL332] [GtoPdb: 1628] [UniProtKB: P03956] | ||||||||
| ChEMBL | In vitro inhibition of human MMP-1. | B | 8.52 | pKi | 3 | nM | Ki | J Med Chem (2001) 44: 2636-2660 [PMID:11472217] |
| MMP13/Matrix metalloproteinase 13 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL280] [GtoPdb: 1637] [UniProtKB: P45452] | ||||||||
| ChEMBL | Inhibition of matrix metalloprotease-13 | B | 9.35 | pKi | 0.45 | nM | Ki | J Med Chem (2001) 44: 2636-2660 [PMID:11472217] |
| GtoPdb | - | - | 9.35 | pKi | 0.45 | nM | Ki | J Med Chem (2001) 44: 2636-60 [PMID:11472217] |
| MMP14/Matrix metalloproteinase 14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3869] [GtoPdb: 1638] [UniProtKB: P50281] | ||||||||
| ChEMBL | Inhibition of matrix metalloprotease-14 | B | 7.03 | pKi | 94 | nM | Ki | J Med Chem (2001) 44: 2636-2660 [PMID:11472217] |
| MMP15/Matrix metalloproteinase 15 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2963] [GtoPdb: 1639] [UniProtKB: P51511] | ||||||||
| ChEMBL | Inhibition of matrix metalloprotease-15 | B | 7.7 | pKi | 20 | nM | Ki | J Med Chem (2001) 44: 2636-2660 [PMID:11472217] |
| GtoPdb | - | - | 7.7 | pKi | 20 | nM | Ki | J Med Chem (2001) 44: 2636-60 [PMID:11472217] |
| MMP16/Matrix metalloproteinase 16 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2200] [GtoPdb: 1640] [UniProtKB: P51512] | ||||||||
| ChEMBL | Inhibition of matrix metalloprotease-16 | B | 7.46 | pKi | 35 | nM | Ki | J Med Chem (2001) 44: 2636-2660 [PMID:11472217] |
| GtoPdb | - | - | 7.46 | pKi | 35 | nM | Ki | J Med Chem (2001) 44: 2636-60 [PMID:11472217] |
| MMP2/Matrix metalloproteinase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL333] [GtoPdb: 1629] [UniProtKB: P08253] | ||||||||
| ChEMBL | Inhibition of matrix metalloprotease-2 | B | 8.96 | pKi | 1.1 | nM | Ki | J Med Chem (2001) 44: 2636-2660 [PMID:11472217] |
| MMP3/Matrix metalloproteinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL283] [GtoPdb: 1630] [UniProtKB: P08254] | ||||||||
| ChEMBL | Inhibition of human MMP-3. | B | 7.85 | pKi | 14 | nM | Ki | J Med Chem (2001) 44: 2636-2660 [PMID:11472217] |
| MMP7/Matrix metalloproteinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4073] [GtoPdb: 1631] [UniProtKB: P09237] | ||||||||
| ChEMBL | Inhibition of matrix metalloprotease-7 | B | 9.1 | pKi | 0.8 | nM | Ki | J Med Chem (2001) 44: 2636-2660 [PMID:11472217] |
| GtoPdb | - | - | 9.1 | pKi | 0.8 | nM | Ki | J Med Chem (2001) 44: 2636-60 [PMID:11472217] |
| MMP8/Matrix metalloproteinase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4588] [GtoPdb: 1632] [UniProtKB: P22894] | ||||||||
| GtoPdb | - | - | 9.3 | pKi | 0.5 | nM | Ki | J Med Chem (2001) 44: 2636-60 [PMID:11472217] |
| ChEMBL | Inhibition of matrix metalloprotease-8 | B | 9.3 | pKi | 0.5 | nM | Ki | J Med Chem (2001) 44: 2636-2660 [PMID:11472217] |
| MMP9/Matrix metalloproteinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL321] [GtoPdb: 1633] [UniProtKB: P14780] | ||||||||
| ChEMBL | In vitro inhibition of human MMP-9. | B | 9.05 | pKi | 0.9 | nM | Ki | J Med Chem (2001) 44: 2636-2660 [PMID:11472217] |
| GtoPdb | - | - | 9.05 | pKi | 0.9 | nM | Ki | J Med Chem (2001) 44: 2636-60 [PMID:11472217] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
