SL422 [Ligand Id: 8629] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL88520 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| ADAM17 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3706] [GtoPdb: 1662] [UniProtKB: P78536] | ||||||||
| ChEMBL | Inhibition of LPS-stimulated TNF-alpha release in human whole blood | F | 6.66 | pIC50 | 220 | nM | IC50 | J Med Chem (2001) 44: 2636-2660 [PMID:11472217] |
| ADAM17 in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3332] [UniProtKB: O77636] | ||||||||
| ChEMBL | Inhibition of porcine TNF-alpha converting enzyme (pTACE). | B | 7.92 | pKi | 12 | nM | Ki | J Med Chem (2001) 44: 2636-2660 [PMID:11472217] |
| MMP1/Matrix metalloproteinase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL332] [GtoPdb: 1628] [UniProtKB: P03956] | ||||||||
| ChEMBL | In vitro inhibition of human MMP-1. | B | 8.52 | pKi | 3 | nM | Ki | J Med Chem (2001) 44: 2636-2660 [PMID:11472217] |
| MMP13/Matrix metalloproteinase 13 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL280] [GtoPdb: 1637] [UniProtKB: P45452] | ||||||||
| ChEMBL | Inhibition of matrix metalloprotease-13 | B | 9.35 | pKi | 0.45 | nM | Ki | J Med Chem (2001) 44: 2636-2660 [PMID:11472217] |
| GtoPdb | - | - | 9.35 | pKi | 0.45 | nM | Ki | J Med Chem (2001) 44: 2636-60 [PMID:11472217] |
| MMP14/Matrix metalloproteinase 14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3869] [GtoPdb: 1638] [UniProtKB: P50281] | ||||||||
| ChEMBL | Inhibition of matrix metalloprotease-14 | B | 7.03 | pKi | 94 | nM | Ki | J Med Chem (2001) 44: 2636-2660 [PMID:11472217] |
| MMP15/Matrix metalloproteinase 15 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2963] [GtoPdb: 1639] [UniProtKB: P51511] | ||||||||
| ChEMBL | Inhibition of matrix metalloprotease-15 | B | 7.7 | pKi | 20 | nM | Ki | J Med Chem (2001) 44: 2636-2660 [PMID:11472217] |
| GtoPdb | - | - | 7.7 | pKi | 20 | nM | Ki | J Med Chem (2001) 44: 2636-60 [PMID:11472217] |
| MMP16/Matrix metalloproteinase 16 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2200] [GtoPdb: 1640] [UniProtKB: P51512] | ||||||||
| ChEMBL | Inhibition of matrix metalloprotease-16 | B | 7.46 | pKi | 35 | nM | Ki | J Med Chem (2001) 44: 2636-2660 [PMID:11472217] |
| GtoPdb | - | - | 7.46 | pKi | 35 | nM | Ki | J Med Chem (2001) 44: 2636-60 [PMID:11472217] |
| MMP2/Matrix metalloproteinase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL333] [GtoPdb: 1629] [UniProtKB: P08253] | ||||||||
| ChEMBL | Inhibition of matrix metalloprotease-2 | B | 8.96 | pKi | 1.1 | nM | Ki | J Med Chem (2001) 44: 2636-2660 [PMID:11472217] |
| MMP3/Matrix metalloproteinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL283] [GtoPdb: 1630] [UniProtKB: P08254] | ||||||||
| ChEMBL | Inhibition of human MMP-3. | B | 7.85 | pKi | 14 | nM | Ki | J Med Chem (2001) 44: 2636-2660 [PMID:11472217] |
| MMP7/Matrix metalloproteinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4073] [GtoPdb: 1631] [UniProtKB: P09237] | ||||||||
| ChEMBL | Inhibition of matrix metalloprotease-7 | B | 9.1 | pKi | 0.8 | nM | Ki | J Med Chem (2001) 44: 2636-2660 [PMID:11472217] |
| GtoPdb | - | - | 9.1 | pKi | 0.8 | nM | Ki | J Med Chem (2001) 44: 2636-60 [PMID:11472217] |
| MMP8/Matrix metalloproteinase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4588] [GtoPdb: 1632] [UniProtKB: P22894] | ||||||||
| GtoPdb | - | - | 9.3 | pKi | 0.5 | nM | Ki | J Med Chem (2001) 44: 2636-60 [PMID:11472217] |
| ChEMBL | Inhibition of matrix metalloprotease-8 | B | 9.3 | pKi | 0.5 | nM | Ki | J Med Chem (2001) 44: 2636-2660 [PMID:11472217] |
| MMP9/Matrix metalloproteinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL321] [GtoPdb: 1633] [UniProtKB: P14780] | ||||||||
| ChEMBL | In vitro inhibition of human MMP-9. | B | 9.05 | pKi | 0.9 | nM | Ki | J Med Chem (2001) 44: 2636-2660 [PMID:11472217] |
| GtoPdb | - | - | 9.05 | pKi | 0.9 | nM | Ki | J Med Chem (2001) 44: 2636-60 [PMID:11472217] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
