SL422 [Ligand Id: 8629] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL88520
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  • MMP1/Matrix metalloproteinase-1 in Human [ChEMBL: CHEMBL332] [GtoPdb: 1628] [UniProtKB: P03956]
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  • MMP13/Matrix metalloproteinase 13 in Human [ChEMBL: CHEMBL280] [GtoPdb: 1637] [UniProtKB: P45452]
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  • MMP14/Matrix metalloproteinase 14 in Human [ChEMBL: CHEMBL3869] [GtoPdb: 1638] [UniProtKB: P50281]
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  • MMP15/Matrix metalloproteinase 15 in Human [ChEMBL: CHEMBL2963] [GtoPdb: 1639] [UniProtKB: P51511]
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  • MMP16/Matrix metalloproteinase 16 in Human [ChEMBL: CHEMBL2200] [GtoPdb: 1640] [UniProtKB: P51512]
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  • MMP2/Matrix metalloproteinase-2 in Human [ChEMBL: CHEMBL333] [GtoPdb: 1629] [UniProtKB: P08253]
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  • MMP3/Matrix metalloproteinase 3 in Human [ChEMBL: CHEMBL283] [GtoPdb: 1630] [UniProtKB: P08254]
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  • MMP9/Matrix metalloproteinase 9 in Human [ChEMBL: CHEMBL321] [GtoPdb: 1633] [UniProtKB: P14780]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
ADAM17 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3706] [GtoPdb: 1662] [UniProtKB: P78536]
ChEMBL Inhibition of LPS-stimulated TNF-alpha release in human whole blood F 6.66 pIC50 220 nM IC50 J Med Chem (2001) 44: 2636-2660 [PMID:11472217]
ADAM17 in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3332] [UniProtKB: O77636]
ChEMBL Inhibition of porcine TNF-alpha converting enzyme (pTACE). B 7.92 pKi 12 nM Ki J Med Chem (2001) 44: 2636-2660 [PMID:11472217]
MMP1/Matrix metalloproteinase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL332] [GtoPdb: 1628] [UniProtKB: P03956]
ChEMBL In vitro inhibition of human MMP-1. B 8.52 pKi 3 nM Ki J Med Chem (2001) 44: 2636-2660 [PMID:11472217]
MMP13/Matrix metalloproteinase 13 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL280] [GtoPdb: 1637] [UniProtKB: P45452]
ChEMBL Inhibition of matrix metalloprotease-13 B 9.35 pKi 0.45 nM Ki J Med Chem (2001) 44: 2636-2660 [PMID:11472217]
GtoPdb - - 9.35 pKi 0.45 nM Ki J Med Chem (2001) 44: 2636-60 [PMID:11472217]
MMP14/Matrix metalloproteinase 14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3869] [GtoPdb: 1638] [UniProtKB: P50281]
ChEMBL Inhibition of matrix metalloprotease-14 B 7.03 pKi 94 nM Ki J Med Chem (2001) 44: 2636-2660 [PMID:11472217]
MMP15/Matrix metalloproteinase 15 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2963] [GtoPdb: 1639] [UniProtKB: P51511]
ChEMBL Inhibition of matrix metalloprotease-15 B 7.7 pKi 20 nM Ki J Med Chem (2001) 44: 2636-2660 [PMID:11472217]
GtoPdb - - 7.7 pKi 20 nM Ki J Med Chem (2001) 44: 2636-60 [PMID:11472217]
MMP16/Matrix metalloproteinase 16 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2200] [GtoPdb: 1640] [UniProtKB: P51512]
ChEMBL Inhibition of matrix metalloprotease-16 B 7.46 pKi 35 nM Ki J Med Chem (2001) 44: 2636-2660 [PMID:11472217]
GtoPdb - - 7.46 pKi 35 nM Ki J Med Chem (2001) 44: 2636-60 [PMID:11472217]
MMP2/Matrix metalloproteinase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL333] [GtoPdb: 1629] [UniProtKB: P08253]
ChEMBL Inhibition of matrix metalloprotease-2 B 8.96 pKi 1.1 nM Ki J Med Chem (2001) 44: 2636-2660 [PMID:11472217]
MMP3/Matrix metalloproteinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL283] [GtoPdb: 1630] [UniProtKB: P08254]
ChEMBL Inhibition of human MMP-3. B 7.85 pKi 14 nM Ki J Med Chem (2001) 44: 2636-2660 [PMID:11472217]
MMP7/Matrix metalloproteinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4073] [GtoPdb: 1631] [UniProtKB: P09237]
ChEMBL Inhibition of matrix metalloprotease-7 B 9.1 pKi 0.8 nM Ki J Med Chem (2001) 44: 2636-2660 [PMID:11472217]
GtoPdb - - 9.1 pKi 0.8 nM Ki J Med Chem (2001) 44: 2636-60 [PMID:11472217]
MMP8/Matrix metalloproteinase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4588] [GtoPdb: 1632] [UniProtKB: P22894]
GtoPdb - - 9.3 pKi 0.5 nM Ki J Med Chem (2001) 44: 2636-60 [PMID:11472217]
ChEMBL Inhibition of matrix metalloprotease-8 B 9.3 pKi 0.5 nM Ki J Med Chem (2001) 44: 2636-2660 [PMID:11472217]
MMP9/Matrix metalloproteinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL321] [GtoPdb: 1633] [UniProtKB: P14780]
ChEMBL In vitro inhibition of human MMP-9. B 9.05 pKi 0.9 nM Ki J Med Chem (2001) 44: 2636-2660 [PMID:11472217]
GtoPdb - - 9.05 pKi 0.9 nM Ki J Med Chem (2001) 44: 2636-60 [PMID:11472217]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]