M826 [Ligand Id: 8654] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL1184755
  • Caspase 1 in Human [GtoPdb: 1617] [UniProtKB: P29466]
There should be some charts here, you may need to enable JavaScript!
  • Caspase 3 in Human [GtoPdb: 1619] [UniProtKB: P42574]
There should be some charts here, you may need to enable JavaScript!
  • Caspase 4 in Human [GtoPdb: 1620] [UniProtKB: P49662]
There should be some charts here, you may need to enable JavaScript!
  • Caspase 5 in Human [GtoPdb: 1621] [UniProtKB: P51878]
There should be some charts here, you may need to enable JavaScript!
  • Caspase 7 in Human [GtoPdb: 1623] [UniProtKB: P55210]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Caspase 1 in Human [GtoPdb: 1617] [UniProtKB: P29466]
GtoPdb - - 7.3 pIC50 50 nM IC50 Bioorg Med Chem Lett (2005) 15: 1173-80 [PMID:15686936]
Caspase 3 in Human [GtoPdb: 1619] [UniProtKB: P42574]
GtoPdb - - 8.3 pKi 5 nM Ki Bioorg Med Chem Lett (2005) 15: 1173-80 [PMID:15686936]
Caspase 4 in Human [GtoPdb: 1620] [UniProtKB: P49662]
GtoPdb - - 6.52 pIC50 300 nM IC50 Bioorg Med Chem Lett (2005) 15: 1173-80 [PMID:15686936]
Caspase 5 in Human [GtoPdb: 1621] [UniProtKB: P51878]
GtoPdb - - 6.7 pIC50 200 nM IC50 Bioorg Med Chem Lett (2005) 15: 1173-80 [PMID:15686936]
Caspase 7 in Human [GtoPdb: 1623] [UniProtKB: P55210]
GtoPdb - - 7.89 pIC50 13 nM IC50 Bioorg Med Chem Lett (2005) 15: 1173-80 [PMID:15686936]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]