LDN-91946 [Ligand Id: 8661] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1190585 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Caspase 3/Caspase-3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2334] [GtoPdb: 1619] [UniProtKB: P42574] | ||||||||
| ChEMBL | Inhibition of caspase3 | B | 4 | pKi | 100000 | nM | Ki | Nat Chem Biol (2007) 3: 697-705 [PMID:17948018] |
| transglutaminase 2/Protein-glutamine gamma-glutamyltransferase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2730] [GtoPdb: 3015] [UniProtKB: P21980] | ||||||||
| ChEMBL | Inhibition of tissue transglutaminase | B | 4 | pKi | 100000 | nM | Ki | Nat Chem Biol (2007) 3: 697-705 [PMID:17948018] |
| ubiquitin specific peptidase 5/Ubiquitin carboxyl-terminal hydrolase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6158] [GtoPdb: 2431] [UniProtKB: P45974] | ||||||||
| ChEMBL | Inhibition of isopeptidase T | B | 4 | pKi | 100000 | nM | Ki | Nat Chem Biol (2007) 3: 697-705 [PMID:17948018] |
| ubiquitin C-terminal hydrolase L1/Ubiquitin carboxyl-terminal hydrolase isozyme L1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6159] [GtoPdb: 2426] [UniProtKB: P09936] | ||||||||
| ChEMBL | Inhibition of UCHL1 | B | 5.55 | pKi | 2800 | nM | Ki | Nat Chem Biol (2007) 3: 697-705 [PMID:17948018] |
| ChEMBL | Inhibition of UCHL1 | B | 5.64 | pKi | 2300 | nM | Ki | Nat Chem Biol (2007) 3: 697-705 [PMID:17948018] |
| GtoPdb | - | - | 5.64 | pKi | 2300 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 3729-32 [PMID:17449248] |
| ubiquitin C-terminal hydrolase L3/Ubiquitin carboxyl-terminal hydrolase isozyme L3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6195] [GtoPdb: 2427] [UniProtKB: P15374] | ||||||||
| ChEMBL | Inhibition of UCHL3 | B | 4 | pKi | 100000 | nM | Ki | Nat Chem Biol (2007) 3: 697-705 [PMID:17948018] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
