compound 10 [PMID: 18790648] [Ligand Id: 8665] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL447457
  • MMP11/Matrix metalloproteinase 11 in Human [ChEMBL: CHEMBL2867] [GtoPdb: 1635] [UniProtKB: P24347]
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  • MMP13/Matrix metalloproteinase 13 in Human [ChEMBL: CHEMBL280] [GtoPdb: 1637] [UniProtKB: P45452]
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  • MMP14/Matrix metalloproteinase 14 in Human [ChEMBL: CHEMBL3869] [GtoPdb: 1638] [UniProtKB: P50281]
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  • MMP2/Matrix metalloproteinase-2 in Human [ChEMBL: CHEMBL333] [GtoPdb: 1629] [UniProtKB: P08253]
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  • MMP9/Matrix metalloproteinase 9 in Human [ChEMBL: CHEMBL321] [GtoPdb: 1633] [UniProtKB: P14780]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
MMP11/Matrix metalloproteinase 11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2867] [GtoPdb: 1635] [UniProtKB: P24347]
GtoPdb - - 6.64 pKi 230 nM Ki Bioorg Med Chem (2008) 16: 8781-94 [PMID:18790648]
ChEMBL Inhibition of MMP11 B 9.64 pKi 0.23 nM Ki Bioorg. Med. Chem. (2008) 16: 8781-8794 [PMID:18790648]
MMP13/Matrix metalloproteinase 13 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL280] [GtoPdb: 1637] [UniProtKB: P45452]
ChEMBL Inhibition of MMP13 B 7.8 pKi 15.7 nM Ki Bioorg. Med. Chem. (2008) 16: 8781-8794 [PMID:18790648]
MMP14/Matrix metalloproteinase 14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3869] [GtoPdb: 1638] [UniProtKB: P50281]
ChEMBL Inhibition of MMP14 B 6.8 pKi 160 nM Ki Bioorg. Med. Chem. (2008) 16: 8781-8794 [PMID:18790648]
MMP2/Matrix metalloproteinase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL333] [GtoPdb: 1629] [UniProtKB: P08253]
ChEMBL Inhibition of MMP2 B 7.52 pKi 30 nM Ki Bioorg. Med. Chem. (2008) 16: 8781-8794 [PMID:18790648]
MMP8/Matrix metalloproteinase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4588] [GtoPdb: 1632] [UniProtKB: P22894]
ChEMBL Inhibition of MMP8 B 7.41 pKi 38.9 nM Ki Bioorg. Med. Chem. (2008) 16: 8781-8794 [PMID:18790648]
MMP9/Matrix metalloproteinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL321] [GtoPdb: 1633] [UniProtKB: P14780]
ChEMBL Inhibition of MMP9 B 7.45 pKi 35.6 nM Ki Bioorg. Med. Chem. (2008) 16: 8781-8794 [PMID:18790648]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]