VS-4718 [Ligand Id: 8742] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL3040440 (VS-4718)
  • mitogen-activated protein kinase 9/c-Jun N-terminal kinase 2 in Human [ChEMBL: CHEMBL4179] [GtoPdb: 1497] [UniProtKB: P45984]
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  • mitogen-activated protein kinase 10/c-Jun N-terminal kinase 3 in Human [ChEMBL: CHEMBL2637] [GtoPdb: 1498] [UniProtKB: P53779]
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  • protein tyrosine kinase 2 in Human [GtoPdb: 2180] [UniProtKB: Q05397]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
mitogen-activated protein kinase 9/c-Jun N-terminal kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4179] [GtoPdb: 1497] [UniProtKB: P45984]
ChEMBL Inhibition of JNK2 (unknown origin) using biotinylated ATF2 by HTRF method B 6.92 pIC50 120 nM IC50 MedChemComm (2012) 3: 238-243
mitogen-activated protein kinase 10/c-Jun N-terminal kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2637] [GtoPdb: 1498] [UniProtKB: P53779]
ChEMBL Inhibition of JNK3 (unknown origin) using biotinylated ATF2 by HTRF method B 6.8 pIC50 160 nM IC50 MedChemComm (2012) 3: 238-243
protein tyrosine kinase 2 in Human [GtoPdb: 2180] [UniProtKB: Q05397]
GtoPdb - - 8.82 pIC50 1.5 nM IC50 Cancer Biol Ther (2010) 9: 764-77 [PMID:20234191]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]