compound 19 [PMID: 22142545] [Ligand Id: 8758] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1939914
  • phosphodiesterase 10A/Phosphodiesterase 10A in Human [ChEMBL: CHEMBL4409] [GtoPdb: 1310] [UniProtKB: Q9Y233]
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  • phosphodiesterase 11A/Phosphodiesterase 11A in Human [ChEMBL: CHEMBL2717] [GtoPdb: 1311] [UniProtKB: Q9HCR9]
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  • phosphodiesterase 1A/Phosphodiesterase 1A in Human [ChEMBL: CHEMBL3421] [GtoPdb: 1294] [UniProtKB: P54750]
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  • phosphodiesterase 2A/Phosphodiesterase 2A in Human [ChEMBL: CHEMBL2652] [GtoPdb: 1297] [UniProtKB: O00408]
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  • phosphodiesterase 3A/Phosphodiesterase 3A in Human [ChEMBL: CHEMBL241] [GtoPdb: 1298] [UniProtKB: Q14432]
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  • phosphodiesterase 4B/Phosphodiesterase 4B in Human [ChEMBL: CHEMBL275] [GtoPdb: 1301] [UniProtKB: Q07343]
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  • phosphodiesterase 5A/Phosphodiesterase 5A in Human [ChEMBL: CHEMBL1827] [GtoPdb: 1304] [UniProtKB: O76074]
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  • phosphodiesterase 7A/Phosphodiesterase 7A in Human [ChEMBL: CHEMBL3012] [GtoPdb: 1305] [UniProtKB: Q13946]
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  • phosphodiesterase 8A/Phosphodiesterase 8A in Human [ChEMBL: CHEMBL4640] [GtoPdb: 1307] [UniProtKB: O60658]
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  • phosphodiesterase 9A/Phosphodiesterase 9A in Human [ChEMBL: CHEMBL3535] [GtoPdb: 1309] [UniProtKB: O76083]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
phosphodiesterase 10A/Phosphodiesterase 10A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4409] [GtoPdb: 1310] [UniProtKB: Q9Y233]
GtoPdb - - 9 pKi 1 nM Ki Bioorg. Med. Chem. Lett. (2012) 22: 235-9 [PMID:22142545]
ChEMBL Displacement of [3H]cAMP from human recombinant PDE10A1 by competitive binding assay B 9 pKi 1 nM Ki Bioorg. Med. Chem. Lett. (2012) 22: 235-239 [PMID:22142545]
phosphodiesterase 11A/Phosphodiesterase 11A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2717] [GtoPdb: 1311] [UniProtKB: Q9HCR9]
ChEMBL Displacement of [3H]cAMP from PDE11A3 by competitive binding assay B 4.84 pKi 14600 nM Ki Bioorg. Med. Chem. Lett. (2012) 22: 235-239 [PMID:22142545]
phosphodiesterase 1A/Phosphodiesterase 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3421] [GtoPdb: 1294] [UniProtKB: P54750]
ChEMBL Displacement of [3H]cAMP from PDE1A3 by competitive binding assay B 5 pKi >10000 nM Ki Bioorg. Med. Chem. Lett. (2012) 22: 235-239 [PMID:22142545]
phosphodiesterase 2A/Phosphodiesterase 2A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2652] [GtoPdb: 1297] [UniProtKB: O00408]
ChEMBL Displacement of [3H]cAMP from PDE2A by competitive binding assay B 5 pKi >10000 nM Ki Bioorg. Med. Chem. Lett. (2012) 22: 235-239 [PMID:22142545]
phosphodiesterase 3A/Phosphodiesterase 3A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL241] [GtoPdb: 1298] [UniProtKB: Q14432]
ChEMBL Displacement of [3H]cAMP from PDE3A by competitive binding assay B 5 pKi >10000 nM Ki Bioorg. Med. Chem. Lett. (2012) 22: 235-239 [PMID:22142545]
phosphodiesterase 4B/Phosphodiesterase 4B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL275] [GtoPdb: 1301] [UniProtKB: Q07343]
ChEMBL Displacement of [3H]cAMP from PDE4B2 by competitive binding assay B 5 pKi >10000 nM Ki Bioorg. Med. Chem. Lett. (2012) 22: 235-239 [PMID:22142545]
phosphodiesterase 5A/Phosphodiesterase 5A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1827] [GtoPdb: 1304] [UniProtKB: O76074]
ChEMBL Displacement of [3H]cAMP from PDE5A1 by competitive binding assay B 4.97 pKi 10600 nM Ki Bioorg. Med. Chem. Lett. (2012) 22: 235-239 [PMID:22142545]
phosphodiesterase 7A/Phosphodiesterase 7A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3012] [GtoPdb: 1305] [UniProtKB: Q13946]
ChEMBL Displacement of [3H]cAMP from PDE7A1 by competitive binding assay B 5 pKi >10000 nM Ki Bioorg. Med. Chem. Lett. (2012) 22: 235-239 [PMID:22142545]
phosphodiesterase 8A/Phosphodiesterase 8A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4640] [GtoPdb: 1307] [UniProtKB: O60658]
ChEMBL Displacement of [3H]cAMP from PDE8A1 by competitive binding assay B 5 pKi >10000 nM Ki Bioorg. Med. Chem. Lett. (2012) 22: 235-239 [PMID:22142545]
phosphodiesterase 9A/Phosphodiesterase 9A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3535] [GtoPdb: 1309] [UniProtKB: O76083]
ChEMBL Displacement of [3H]cAMP from PDE9A1 by competitive binding assay B 5 pKi >10000 nM Ki Bioorg. Med. Chem. Lett. (2012) 22: 235-239 [PMID:22142545]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]