compound 44 [PMID: 19748780] [Ligand Id: 8761] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL565406 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| mPGES1/Prostaglandin E synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5658] [GtoPdb: 1377] [UniProtKB: O14684] | ||||||||
| GtoPdb | - | - | 9 | pIC50 | 1 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5837-41 [PMID:19748780] |
| ChEMBL | Displacement of [3H]PGH2 from human recombinant PGES1 expressed in CHOK1 cells | B | 9 | pIC50 | 1 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5837-5841 [PMID:19748780] |
| ChEMBL | Inhibition of mPGES-1 in IL-1beta-stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 formation incubated for 15 mins using PGH2 substrate by RP-HPLC method | B | 9 | pIC50 | 1 | nM | IC50 | Bioorg Med Chem (2015) 23: 4839-4845 [PMID:26088337] |
| mPGES2/Prostaglandin E synthase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4411] [GtoPdb: 1378] [UniProtKB: Q9H7Z7] | ||||||||
| ChEMBL | Inhibition of human PGES2 | B | 4.52 | pIC50 | >30000 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5837-5841 [PMID:19748780] |
| CYP5A1/Thromboxane-A synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1835] [GtoPdb: 1353] [UniProtKB: P24557] | ||||||||
| ChEMBL | Inhibition of TX synthase | B | 4.52 | pIC50 | 30000 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5837-5841 [PMID:19748780] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
