compound 57 [PMID: 16610804] [Ligand Id: 8771] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL443834
  • cPLA2-4A/Cytosolic phospholipase A2 in Human [ChEMBL: CHEMBL3816] [GtoPdb: 1424] [UniProtKB: P47712]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
cPLA2-4A/Cytosolic phospholipase A2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3816] [GtoPdb: 1424] [UniProtKB: P47712]
ChEMBL Inhibition of cPLA2alpha activity assessed by A23187-induced arachidonic acid release in human platelet F 6.24 pIC50 570 nM IC50 J. Med. Chem. (2006) 49: 2611-2620 [PMID:16610804]
ChEMBL Inhibition of human isolated cPLA2-alpha by vesicle assay B 8.37 pIC50 4.3 nM IC50 J. Med. Chem. (2006) 49: 2611-2620 [PMID:16610804]
GtoPdb Inhibition of human isolated cPLA2-4A in a lipid vesicle assay. - 8.37 pIC50 4.3 nM IC50 J Med Chem (2006) 49: 2611-20 [PMID:16610804]
ChEMBL Inhibition of cPLA2-alpha activity assessed by TPA-induced arachidonic acid release in human platelet F 9.05 pIC50 0.9 nM IC50 J. Med. Chem. (2006) 49: 2611-2620 [PMID:16610804]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]