compound 8e [PMID: 23044371] [Ligand Id: 8780] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2159857 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| SUMO specific peptidase 1/Sentrin-specific protease 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1909484] [GtoPdb: 2414] [UniProtKB: Q9P0U3] | ||||||||
| GtoPdb | - | - | 5.73 | pIC50 | 1856 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 6867-70 [PMID:23044371] |
| ChEMBL | Inhibition of recombinant His-tagged SENP1 catalytic domain expressed in Escherichia coli BL21(DE3) using His-tagged deltaRanGAP-SUMO2 as substrate incubated for 10 mins prior to substrate addition measured after 45 mins by SDS-PAGE analysis | B | 5.97 | pIC50 | 1080 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 6867-6870 [PMID:23044371] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
