compound 8e [PMID: 23044371] [Ligand Id: 8780] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2159857 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| SUMO specific peptidase 1/Sentrin-specific protease 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1909484] [GtoPdb: 2414] [UniProtKB: Q9P0U3] | ||||||||
| GtoPdb | - | - | 5.73 | pIC50 | 1856 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 6867-70 [PMID:23044371] |
| ChEMBL | Inhibition of recombinant His-tagged SENP1 catalytic domain expressed in Escherichia coli BL21(DE3) using His-tagged deltaRanGAP-SUMO2 as substrate incubated for 10 mins prior to substrate addition measured after 45 mins by SDS-PAGE analysis | B | 5.97 | pIC50 | 1080 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 6867-6870 [PMID:23044371] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
