compound 8e [PMID: 23044371] [Ligand Id: 8780] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2159857
  • SUMO specific peptidase 1/Sentrin-specific protease 1 in Human [ChEMBL: CHEMBL1909484] [GtoPdb: 2414] [UniProtKB: Q9P0U3]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
SUMO specific peptidase 1/Sentrin-specific protease 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1909484] [GtoPdb: 2414] [UniProtKB: Q9P0U3]
GtoPdb - - 5.73 pIC50 1856 nM IC50 Bioorg. Med. Chem. Lett. (2012) 22: 6867-70 [PMID:23044371]
ChEMBL Inhibition of recombinant His-tagged SENP1 catalytic domain expressed in Escherichia coli BL21(DE3) using His-tagged deltaRanGAP-SUMO2 as substrate incubated for 10 mins prior to substrate addition measured after 45 mins by SDS-PAGE analysis B 5.97 pIC50 1080 nM IC50 Bioorg. Med. Chem. Lett. (2012) 22: 6867-6870 [PMID:23044371]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]