FIPI [Ligand Id: 8781] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL398567
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
PLD1/Phospholipase D1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2536] [GtoPdb: 1433] [UniProtKB: Q13393]
GtoPdb - - 8.02 pIC50 9.5 nM IC50 Nat Chem Biol (2009) 5: 108-17 [PMID:19136975]
ChEMBL Inhibition of human PLD1 assessed as release of methyl-[3H]choline from choline-methyl-[3H]dipalmitoylphosphatidylcholine after 30 mins by exogenous substrate assay B 8.02 pIC50 9.5 nM IC50 Nat Chem Biol (2009) 5: 108-117 [PMID:19136975]
ChEMBL Inhibition of PLD1 in human Calu-1 cells assessed as decrease in phosphatidylbutanol-[d9] production after 30 mins by mass spectrometric analysis B 9 pIC50 1 nM IC50 Nat Chem Biol (2009) 5: 108-117 [PMID:19136975]
PLD1/Phospholipase D1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3308939] [GtoPdb: 1433] [UniProtKB: P70496]
ChEMBL Inhibition of N-terminally truncated rat PLD1 assessed as release of methyl-[3H]choline from choline-methyl-[3H]dipalmitoylphosphatidylcholine after 30 mins by exogenous substrate assay B 7.48 pIC50 33 nM IC50 Nat Chem Biol (2009) 5: 108-117 [PMID:19136975]
PLD2/Phospholipase D2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2734] [GtoPdb: 1434] [UniProtKB: O14939]
ChEMBL Inhibition of GFP-tagged human PLD2 expressed in human HEK293 cells assessed as decrease in phosphatidylbutanol-[d9] production after 30 mins by mass spectrometric analysis B 6.52 pIC50 300 nM IC50 Nat Chem Biol (2009) 5: 108-117 [PMID:19136975]
ChEMBL Inhibition of PLD2 B 7.7 pIC50 20 nM IC50 Bioorg Med Chem Lett (2007) 17: 2310-2311 [PMID:17317170]
ChEMBL Inhibition of human PLD2 assessed as release of methyl-[3H]choline from choline-methyl-[3H]dipalmitoylphosphatidylcholine after 30 mins by exogenous substrate assay B 7.77 pIC50 17 nM IC50 Nat Chem Biol (2009) 5: 108-117 [PMID:19136975]
GtoPdb - - 7.77 pIC50 17 nM IC50 Nat Chem Biol (2009) 5: 108-17 [PMID:19136975]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]