FIPI [Ligand Id: 8781] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL398567
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
PLD1/Phospholipase D1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2536] [GtoPdb: 1433] [UniProtKB: Q13393]
GtoPdb - - 8.02 pIC50 9.5 nM IC50 Nat Chem Biol (2009) 5: 108-17 [PMID:19136975]
ChEMBL Inhibition of human PLD1 assessed as release of methyl-[3H]choline from choline-methyl-[3H]dipalmitoylphosphatidylcholine after 30 mins by exogenous substrate assay B 8.02 pIC50 9.5 nM IC50 Nat. Chem. Biol. (2009) 5: 108-117 [PMID:19136975]
ChEMBL Inhibition of PLD1 in human Calu-1 cells assessed as decrease in phosphatidylbutanol-[d9] production after 30 mins by mass spectrometric analysis B 9 pIC50 1 nM IC50 Nat. Chem. Biol. (2009) 5: 108-117 [PMID:19136975]
PLD1/Phospholipase D1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3308939] [GtoPdb: 1433] [UniProtKB: P70496]
ChEMBL Inhibition of N-terminally truncated rat PLD1 assessed as release of methyl-[3H]choline from choline-methyl-[3H]dipalmitoylphosphatidylcholine after 30 mins by exogenous substrate assay B 7.48 pIC50 33 nM IC50 Nat. Chem. Biol. (2009) 5: 108-117 [PMID:19136975]
PLD2/Phospholipase D2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2734] [GtoPdb: 1434] [UniProtKB: O14939]
ChEMBL Inhibition of GFP-tagged human PLD2 expressed in human HEK293 cells assessed as decrease in phosphatidylbutanol-[d9] production after 30 mins by mass spectrometric analysis B 6.52 pIC50 300 nM IC50 Nat. Chem. Biol. (2009) 5: 108-117 [PMID:19136975]
ChEMBL Inhibition of PLD2 B 7.7 pIC50 20 nM IC50 Bioorg. Med. Chem. Lett. (2007) 17: 2310-2311 [PMID:17317170]
ChEMBL Inhibition of human PLD2 assessed as release of methyl-[3H]choline from choline-methyl-[3H]dipalmitoylphosphatidylcholine after 30 mins by exogenous substrate assay B 7.77 pIC50 17 nM IC50 Nat. Chem. Biol. (2009) 5: 108-117 [PMID:19136975]
GtoPdb - - 7.77 pIC50 17 nM IC50 Nat Chem Biol (2009) 5: 108-17 [PMID:19136975]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]