compound 12e [PMID: 18605714] [Ligand Id: 8787] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL515637
  • sPLA2-2D/Group IID secretory phospholipase A2 in Human [ChEMBL: CHEMBL4281] [GtoPdb: 1418] [UniProtKB: Q9UNK4]
  • sPLA2-2D/Group IID secretory phospholipase A2 in Mouse [ChEMBL: CHEMBL5537] [GtoPdb: 1418] [UniProtKB: Q9WVF6]
There should be some charts here, you may need to enable JavaScript!
  • sPLA2-2E/Group IIE secretory phospholipase A2 in Human [ChEMBL: CHEMBL2154] [GtoPdb: 1419] [UniProtKB: Q9NZK7]
  • sPLA2-2E/Group IIE secretory phospholipase A2 in Mouse [ChEMBL: CHEMBL4201] [GtoPdb: 1419] [UniProtKB: Q9QUL3]
There should be some charts here, you may need to enable JavaScript!
  • sPLA2-2F/Group IIF secretory phospholipase A2 in Human [ChEMBL: CHEMBL4278] [GtoPdb: 1420] [UniProtKB: Q9BZM2]
  • sPLA2-2F/Group IIF secretory phospholipase A2 in Mouse [ChEMBL: CHEMBL5361] [GtoPdb: 1420] [UniProtKB: Q9QZT4]
There should be some charts here, you may need to enable JavaScript!
  • sPLA2-10/Group X secretory phospholipase A2 in Human [ChEMBL: CHEMBL4342] [GtoPdb: 1422] [UniProtKB: O15496]
  • sPLA2-10/Group X secretory phospholipase A2 in Mouse [ChEMBL: CHEMBL4200] [GtoPdb: 1422] [UniProtKB: Q9QXX3]
There should be some charts here, you may need to enable JavaScript!
  • sPLA2-1B/Phospholipase A2 group 1B in Human [ChEMBL: CHEMBL4426] [GtoPdb: 1416] [UniProtKB: P04054]
  • sPLA2-1B/Phospholipase A2 group 1B in Mouse [ChEMBL: CHEMBL4378] [GtoPdb: 1416] [UniProtKB: Q9Z0Y2]
There should be some charts here, you may need to enable JavaScript!
  • sPLA2-2A/Phospholipase A2 group IIA in Human [ChEMBL: CHEMBL3474] [GtoPdb: 1417] [UniProtKB: P14555]
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
  • sPLA2-2A in Human [GtoPdb: 1417] [UniProtKB: P14555]
  • sPLA2-2A/Phospholipase A2, membrane associated in Mouse [ChEMBL: CHEMBL5761] [GtoPdb: 1417] [UniProtKB: P31482]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
sPLA2-2D/Group IID secretory phospholipase A2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4281] [GtoPdb: 1418] [UniProtKB: Q9UNK4]
GtoPdb - - 8.15 pIC50 7 nM IC50 J Med Chem (2008) 51: 4708-14 [PMID:18605714]
ChEMBL Inhibition of human group2D phospholipase A2 by [3H]oleic acid-labeled Escherichia coli membrane assay B 8.15 pIC50 7 nM IC50 J Med Chem (2008) 51: 4708-4714 [PMID:18605714]
sPLA2-2D/Group IID secretory phospholipase A2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5537] [GtoPdb: 1418] [UniProtKB: Q9WVF6]
ChEMBL Inhibition of mouse group2D phospholipase A2 fluorimetric assay B 6.49 pIC50 320 nM IC50 J Med Chem (2008) 51: 4708-4714 [PMID:18605714]
sPLA2-2E/Group IIE secretory phospholipase A2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2154] [GtoPdb: 1419] [UniProtKB: Q9NZK7]
GtoPdb - - 8.15 pIC50 7 nM IC50 J Med Chem (2008) 51: 4708-14 [PMID:18605714]
ChEMBL Inhibition of human group2E phospholipase A2 fluorimetric assay B 8.15 pIC50 7 nM IC50 J Med Chem (2008) 51: 4708-4714 [PMID:18605714]
sPLA2-2E/Group IIE secretory phospholipase A2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4201] [GtoPdb: 1419] [UniProtKB: Q9QUL3]
ChEMBL Inhibition of mouse group2E phospholipase A2 fluorimetric assay B 7.74 pIC50 18 nM IC50 J Med Chem (2008) 51: 4708-4714 [PMID:18605714]
sPLA2-2F/Group IIF secretory phospholipase A2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4278] [GtoPdb: 1420] [UniProtKB: Q9BZM2]
GtoPdb - - 7.3 pIC50 50 nM IC50 J Med Chem (2008) 51: 4708-14 [PMID:18605714]
ChEMBL Inhibition of human group2F phospholipase A2 fluorimetric assay B 7.3 pIC50 50 nM IC50 J Med Chem (2008) 51: 4708-4714 [PMID:18605714]
sPLA2-2F/Group IIF secretory phospholipase A2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5361] [GtoPdb: 1420] [UniProtKB: Q9QZT4]
ChEMBL Inhibition of mouse group2F phospholipase A2 fluorimetric assay B 6.77 pIC50 170 nM IC50 J Med Chem (2008) 51: 4708-4714 [PMID:18605714]
sPLA2-10/Group X secretory phospholipase A2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4342] [GtoPdb: 1422] [UniProtKB: O15496]
ChEMBL Inhibition of human group2X phospholipase A2 fluorimetric assay B 7.7 pIC50 20 nM IC50 J Med Chem (2008) 51: 4708-4714 [PMID:18605714]
GtoPdb - - 7.7 pIC50 20 nM IC50 J Med Chem (2008) 51: 4708-14 [PMID:18605714]
sPLA2-10/Group X secretory phospholipase A2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4200] [GtoPdb: 1422] [UniProtKB: Q9QXX3]
ChEMBL Inhibition of mouse group2X phospholipase A2 fluorimetric assay B 8.22 pIC50 6 nM IC50 J Med Chem (2008) 51: 4708-4714 [PMID:18605714]
sPLA2-1B/Phospholipase A2 group 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4426] [GtoPdb: 1416] [UniProtKB: P04054]
ChEMBL Inhibition of human group1B phospholipase A2 fluorimetric assay B 7.08 pIC50 84 nM IC50 J Med Chem (2008) 51: 4708-4714 [PMID:18605714]
GtoPdb - - 7.08 pIC50 84 nM IC50 J Med Chem (2008) 51: 4708-14 [PMID:18605714]
sPLA2-1B/Phospholipase A2 group 1B in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4378] [GtoPdb: 1416] [UniProtKB: Q9Z0Y2]
ChEMBL Inhibition of mouse group1B phospholipase A2 fluorimetric assay B 6.8 pIC50 160 nM IC50 J Med Chem (2008) 51: 4708-4714 [PMID:18605714]
sPLA2-2A/Phospholipase A2 group IIA in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3474] [GtoPdb: 1417] [UniProtKB: P14555]
ChEMBL Inhibition of human group2A phospholipase A2 fluorimetric assay B 7.4 pIC50 40 nM IC50 J Med Chem (2008) 51: 4708-4714 [PMID:18605714]
GtoPdb - - 7.4 pIC50 40 nM IC50 J Med Chem (2008) 51: 4708-14 [PMID:18605714]
PLA2-G5/Phospholipase A2 group V in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4323] [GtoPdb: 1430] [UniProtKB: P39877]
ChEMBL Inhibition of human group2V phospholipase A2 fluorimetric assay B 7.46 pIC50 35 nM IC50 J Med Chem (2008) 51: 4708-4714 [PMID:18605714]
GtoPdb - - 7.46 pIC50 35 nM IC50 J Med Chem (2008) 51: 4708-14 [PMID:18605714]
PLA2-G5/Phospholipase A2 group V in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4167] [GtoPdb: 1430] [UniProtKB: P97391]
ChEMBL Inhibition of mouse group2V phospholipase A2 fluorimetric assay B 7.7 pIC50 20 nM IC50 J Med Chem (2008) 51: 4708-4714 [PMID:18605714]
sPLA2-2A in Human [GtoPdb: 1417] [UniProtKB: P14555]
GtoPdb - - 7.4 pIC50 40 nM IC50 J Med Chem (2008) 51: 4708-14 [PMID:18605714]
sPLA2-2A/Phospholipase A2, membrane associated in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5761] [GtoPdb: 1417] [UniProtKB: P31482]
ChEMBL Inhibition of mouse group2A phospholipase A2 fluorimetric assay B 7.52 pIC50 30 nM IC50 J Med Chem (2008) 51: 4708-4714 [PMID:18605714]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]