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ChEMBL ligand: CHEMBL515637 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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sPLA2-2D/Group IID secretory phospholipase A2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4281] [GtoPdb: 1418] [UniProtKB: Q9UNK4] | ||||||||
GtoPdb | - | - | 8.15 | pIC50 | 7 | nM | IC50 | J Med Chem (2008) 51: 4708-14 [PMID:18605714] |
ChEMBL | Inhibition of human group2D phospholipase A2 by [3H]oleic acid-labeled Escherichia coli membrane assay | B | 8.15 | pIC50 | 7 | nM | IC50 | J Med Chem (2008) 51: 4708-4714 [PMID:18605714] |
sPLA2-2D/Group IID secretory phospholipase A2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5537] [GtoPdb: 1418] [UniProtKB: Q9WVF6] | ||||||||
ChEMBL | Inhibition of mouse group2D phospholipase A2 fluorimetric assay | B | 6.49 | pIC50 | 320 | nM | IC50 | J Med Chem (2008) 51: 4708-4714 [PMID:18605714] |
sPLA2-2E/Group IIE secretory phospholipase A2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2154] [GtoPdb: 1419] [UniProtKB: Q9NZK7] | ||||||||
GtoPdb | - | - | 8.15 | pIC50 | 7 | nM | IC50 | J Med Chem (2008) 51: 4708-14 [PMID:18605714] |
ChEMBL | Inhibition of human group2E phospholipase A2 fluorimetric assay | B | 8.15 | pIC50 | 7 | nM | IC50 | J Med Chem (2008) 51: 4708-4714 [PMID:18605714] |
sPLA2-2E/Group IIE secretory phospholipase A2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4201] [GtoPdb: 1419] [UniProtKB: Q9QUL3] | ||||||||
ChEMBL | Inhibition of mouse group2E phospholipase A2 fluorimetric assay | B | 7.74 | pIC50 | 18 | nM | IC50 | J Med Chem (2008) 51: 4708-4714 [PMID:18605714] |
sPLA2-2F/Group IIF secretory phospholipase A2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4278] [GtoPdb: 1420] [UniProtKB: Q9BZM2] | ||||||||
GtoPdb | - | - | 7.3 | pIC50 | 50 | nM | IC50 | J Med Chem (2008) 51: 4708-14 [PMID:18605714] |
ChEMBL | Inhibition of human group2F phospholipase A2 fluorimetric assay | B | 7.3 | pIC50 | 50 | nM | IC50 | J Med Chem (2008) 51: 4708-4714 [PMID:18605714] |
sPLA2-2F/Group IIF secretory phospholipase A2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5361] [GtoPdb: 1420] [UniProtKB: Q9QZT4] | ||||||||
ChEMBL | Inhibition of mouse group2F phospholipase A2 fluorimetric assay | B | 6.77 | pIC50 | 170 | nM | IC50 | J Med Chem (2008) 51: 4708-4714 [PMID:18605714] |
sPLA2-10/Group X secretory phospholipase A2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4342] [GtoPdb: 1422] [UniProtKB: O15496] | ||||||||
ChEMBL | Inhibition of human group2X phospholipase A2 fluorimetric assay | B | 7.7 | pIC50 | 20 | nM | IC50 | J Med Chem (2008) 51: 4708-4714 [PMID:18605714] |
GtoPdb | - | - | 7.7 | pIC50 | 20 | nM | IC50 | J Med Chem (2008) 51: 4708-14 [PMID:18605714] |
sPLA2-10/Group X secretory phospholipase A2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4200] [GtoPdb: 1422] [UniProtKB: Q9QXX3] | ||||||||
ChEMBL | Inhibition of mouse group2X phospholipase A2 fluorimetric assay | B | 8.22 | pIC50 | 6 | nM | IC50 | J Med Chem (2008) 51: 4708-4714 [PMID:18605714] |
sPLA2-1B/Phospholipase A2 group 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4426] [GtoPdb: 1416] [UniProtKB: P04054] | ||||||||
ChEMBL | Inhibition of human group1B phospholipase A2 fluorimetric assay | B | 7.08 | pIC50 | 84 | nM | IC50 | J Med Chem (2008) 51: 4708-4714 [PMID:18605714] |
GtoPdb | - | - | 7.08 | pIC50 | 84 | nM | IC50 | J Med Chem (2008) 51: 4708-14 [PMID:18605714] |
sPLA2-1B/Phospholipase A2 group 1B in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4378] [GtoPdb: 1416] [UniProtKB: Q9Z0Y2] | ||||||||
ChEMBL | Inhibition of mouse group1B phospholipase A2 fluorimetric assay | B | 6.8 | pIC50 | 160 | nM | IC50 | J Med Chem (2008) 51: 4708-4714 [PMID:18605714] |
sPLA2-2A/Phospholipase A2 group IIA in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3474] [GtoPdb: 1417] [UniProtKB: P14555] | ||||||||
ChEMBL | Inhibition of human group2A phospholipase A2 fluorimetric assay | B | 7.4 | pIC50 | 40 | nM | IC50 | J Med Chem (2008) 51: 4708-4714 [PMID:18605714] |
GtoPdb | - | - | 7.4 | pIC50 | 40 | nM | IC50 | J Med Chem (2008) 51: 4708-14 [PMID:18605714] |
PLA2-G5/Phospholipase A2 group V in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4323] [GtoPdb: 1430] [UniProtKB: P39877] | ||||||||
ChEMBL | Inhibition of human group2V phospholipase A2 fluorimetric assay | B | 7.46 | pIC50 | 35 | nM | IC50 | J Med Chem (2008) 51: 4708-4714 [PMID:18605714] |
GtoPdb | - | - | 7.46 | pIC50 | 35 | nM | IC50 | J Med Chem (2008) 51: 4708-14 [PMID:18605714] |
PLA2-G5/Phospholipase A2 group V in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4167] [GtoPdb: 1430] [UniProtKB: P97391] | ||||||||
ChEMBL | Inhibition of mouse group2V phospholipase A2 fluorimetric assay | B | 7.7 | pIC50 | 20 | nM | IC50 | J Med Chem (2008) 51: 4708-4714 [PMID:18605714] |
sPLA2-2A in Human [GtoPdb: 1417] [UniProtKB: P14555] | ||||||||
GtoPdb | - | - | 7.4 | pIC50 | 40 | nM | IC50 | J Med Chem (2008) 51: 4708-14 [PMID:18605714] |
sPLA2-2A/Phospholipase A2, membrane associated in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5761] [GtoPdb: 1417] [UniProtKB: P31482] | ||||||||
ChEMBL | Inhibition of mouse group2A phospholipase A2 fluorimetric assay | B | 7.52 | pIC50 | 30 | nM | IC50 | J Med Chem (2008) 51: 4708-4714 [PMID:18605714] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]