compound 7p [PMID: 7861416] [Ligand Id: 8795] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL159859
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
CYP8A1/Prostaglandin I2 synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4428] [GtoPdb: 1356] [UniProtKB: Q16647]
ChEMBL In vitro inhibition of Prostaglandin I2 synthase from human blood platelet microsomes B 5.4 pIC50 4000 nM IC50 J Med Chem (1995) 38: 686-694 [PMID:7861416]
ChEMBL In vitro inhibition of Prostaglandin I2 synthase from human blood platelet microsomes B 5.47 pIC50 3400 nM IC50 J Med Chem (1995) 38: 686-694 [PMID:7861416]
GtoPdb - - 6 pIC50 <1000 nM IC50 J Med Chem (1995) 38: 686-94 [PMID:7861416]
ChEMBL In vitro inhibition of Prostaglandin I2 synthase from human blood platelet microsomes B 6 pIC50 <1000 nM IC50 J Med Chem (1995) 38: 686-694 [PMID:7861416]
CYP5A1/Thromboxane-A synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1835] [GtoPdb: 1353] [UniProtKB: P24557]
GtoPdb - - 5 pIC50 >10000 nM IC50 J Med Chem (1995) 38: 686-94 [PMID:7861416]
ChEMBL In vitro Inhibition of thromboxane synthase from human blood platelet microsomes B 5 pIC50 >10000 nM IC50 J Med Chem (1995) 38: 686-694 [PMID:7861416]
ChEMBL In vitro Inhibition of thromboxane synthase from human blood platelet microsomes B 7.29 pIC50 51 nM IC50 J Med Chem (1995) 38: 686-694 [PMID:7861416]
ChEMBL In vitro Inhibition of thromboxane synthase from human blood platelet microsomes B 7.66 pIC50 22 nM IC50 J Med Chem (1995) 38: 686-694 [PMID:7861416]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]