compound 7p [PMID: 7861416] [Ligand Id: 8795] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL159859 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CYP8A1/Prostaglandin I2 synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4428] [GtoPdb: 1356] [UniProtKB: Q16647] | ||||||||
| ChEMBL | In vitro inhibition of Prostaglandin I2 synthase from human blood platelet microsomes | B | 5.4 | pIC50 | 4000 | nM | IC50 | J Med Chem (1995) 38: 686-694 [PMID:7861416] |
| ChEMBL | In vitro inhibition of Prostaglandin I2 synthase from human blood platelet microsomes | B | 5.47 | pIC50 | 3400 | nM | IC50 | J Med Chem (1995) 38: 686-694 [PMID:7861416] |
| GtoPdb | - | - | 6 | pIC50 | <1000 | nM | IC50 | J Med Chem (1995) 38: 686-94 [PMID:7861416] |
| ChEMBL | In vitro inhibition of Prostaglandin I2 synthase from human blood platelet microsomes | B | 6 | pIC50 | <1000 | nM | IC50 | J Med Chem (1995) 38: 686-694 [PMID:7861416] |
| CYP5A1/Thromboxane-A synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1835] [GtoPdb: 1353] [UniProtKB: P24557] | ||||||||
| GtoPdb | - | - | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (1995) 38: 686-94 [PMID:7861416] |
| ChEMBL | In vitro Inhibition of thromboxane synthase from human blood platelet microsomes | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (1995) 38: 686-694 [PMID:7861416] |
| ChEMBL | In vitro Inhibition of thromboxane synthase from human blood platelet microsomes | B | 7.29 | pIC50 | 51 | nM | IC50 | J Med Chem (1995) 38: 686-694 [PMID:7861416] |
| ChEMBL | In vitro Inhibition of thromboxane synthase from human blood platelet microsomes | B | 7.66 | pIC50 | 22 | nM | IC50 | J Med Chem (1995) 38: 686-694 [PMID:7861416] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
