naphthylvinylmethylpyridine [Ligand Id: 8807] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL106212
  • choline O-acetyltransferase/Choline acetylase in Human [ChEMBL: CHEMBL4039] [GtoPdb: 2480] [UniProtKB: P28329]
  • choline O-acetyltransferase in Mouse [GtoPdb: 2480] [UniProtKB: Q03059]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
choline O-acetyltransferase/Choline acetylase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4039] [GtoPdb: 2480] [UniProtKB: P28329]
ChEMBL Inhibition of Choline Acetyltransferase B 6.4 pIC50 400 nM IC50 J Med Chem (1994) 37: 3128-3131 [PMID:7932536]
choline O-acetyltransferase in Mouse [GtoPdb: 2480] [UniProtKB: Q03059]
GtoPdb - - 6.47 pIC50 340 nM IC50 J Med Chem (1988) 31: 807-14 [PMID:3351860]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]