compound 53 [PMID: 19631533] [Ligand Id: 8811] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL567470
  • phosphodiesterase 11A/Phosphodiesterase 11A in Human [ChEMBL: CHEMBL2717] [GtoPdb: 1311] [UniProtKB: Q9HCR9]
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  • phosphodiesterase 1A/Phosphodiesterase 1A in Human [ChEMBL: CHEMBL3421] [GtoPdb: 1294] [UniProtKB: P54750]
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  • phosphodiesterase 1B/Phosphodiesterase 1B in Human [ChEMBL: CHEMBL4425] [GtoPdb: 1295] [UniProtKB: Q01064]
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  • phosphodiesterase 1C/Phosphodiesterase 1C in Human [ChEMBL: CHEMBL4619] [GtoPdb: 1296] [UniProtKB: Q14123]
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  • phosphodiesterase 2A/Phosphodiesterase 2A in Human [ChEMBL: CHEMBL2652] [GtoPdb: 1297] [UniProtKB: O00408]
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  • phosphodiesterase 3A/Phosphodiesterase 3A in Human [ChEMBL: CHEMBL241] [GtoPdb: 1298] [UniProtKB: Q14432]
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  • phosphodiesterase 3B/Phosphodiesterase 3B in Human [ChEMBL: CHEMBL290] [GtoPdb: 1299] [UniProtKB: Q13370]
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  • phosphodiesterase 4A/Phosphodiesterase 4A in Human [ChEMBL: CHEMBL254] [GtoPdb: 1300] [UniProtKB: P27815]
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  • phosphodiesterase 4B/Phosphodiesterase 4B in Human [ChEMBL: CHEMBL275] [GtoPdb: 1301] [UniProtKB: Q07343]
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  • phosphodiesterase 4C/Phosphodiesterase 4C in Human [ChEMBL: CHEMBL291] [GtoPdb: 1302] [UniProtKB: Q08493]
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  • phosphodiesterase 4D/Phosphodiesterase 4D in Human [ChEMBL: CHEMBL288] [GtoPdb: 1303] [UniProtKB: Q08499]
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  • phosphodiesterase 5A/Phosphodiesterase 5A in Human [ChEMBL: CHEMBL1827] [GtoPdb: 1304] [UniProtKB: O76074]
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  • phosphodiesterase 6A/Phosphodiesterase 6A in Human [ChEMBL: CHEMBL3878] [GtoPdb: 1312] [UniProtKB: P16499]
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  • phosphodiesterase 7A/Phosphodiesterase 7A in Human [ChEMBL: CHEMBL3012] [GtoPdb: 1305] [UniProtKB: Q13946]
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  • phosphodiesterase 7B/Phosphodiesterase 7B in Human [ChEMBL: CHEMBL4716] [GtoPdb: 1306] [UniProtKB: Q9NP56]
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  • phosphodiesterase 8A/Phosphodiesterase 8A in Human [ChEMBL: CHEMBL4640] [GtoPdb: 1307] [UniProtKB: O60658]
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  • phosphodiesterase 8B/Phosphodiesterase 8B in Human [ChEMBL: CHEMBL4408] [GtoPdb: 1308] [UniProtKB: O95263]
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  • phosphodiesterase 9A/Phosphodiesterase 9A in Human [ChEMBL: CHEMBL3535] [GtoPdb: 1309] [UniProtKB: O76083]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
phosphodiesterase 11A/Phosphodiesterase 11A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2717] [GtoPdb: 1311] [UniProtKB: Q9HCR9]
ChEMBL Inhibition of PDE11 B 7.19 pIC50 64.1 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 5209-5213 [PMID:19631533]
phosphodiesterase 1A/Phosphodiesterase 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3421] [GtoPdb: 1294] [UniProtKB: P54750]
ChEMBL Inhibition of PDE1A B 5.7 pIC50 >2000 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 5209-5213 [PMID:19631533]
phosphodiesterase 1B/Phosphodiesterase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4425] [GtoPdb: 1295] [UniProtKB: Q01064]
ChEMBL Inhibition of PDE1B B 5.7 pIC50 >2000 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 5209-5213 [PMID:19631533]
phosphodiesterase 1C/Phosphodiesterase 1C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4619] [GtoPdb: 1296] [UniProtKB: Q14123]
ChEMBL Inhibition of PDE1C B 5.7 pIC50 >2000 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 5209-5213 [PMID:19631533]
phosphodiesterase 2A/Phosphodiesterase 2A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2652] [GtoPdb: 1297] [UniProtKB: O00408]
ChEMBL Inhibition of PDE2 B 5.7 pIC50 >2000 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 5209-5213 [PMID:19631533]
phosphodiesterase 3A/Phosphodiesterase 3A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL241] [GtoPdb: 1298] [UniProtKB: Q14432]
ChEMBL Inhibition of PDE3A B 5.7 pIC50 >2000 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 5209-5213 [PMID:19631533]
phosphodiesterase 3B/Phosphodiesterase 3B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL290] [GtoPdb: 1299] [UniProtKB: Q13370]
ChEMBL Inhibition of PDE3B B 5.7 pIC50 >2000 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 5209-5213 [PMID:19631533]
phosphodiesterase 4A/Phosphodiesterase 4A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL254] [GtoPdb: 1300] [UniProtKB: P27815]
ChEMBL Inhibition of PDE4A B 5.7 pIC50 >2000 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 5209-5213 [PMID:19631533]
phosphodiesterase 4B/Phosphodiesterase 4B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL275] [GtoPdb: 1301] [UniProtKB: Q07343]
ChEMBL Inhibition of PDE4B B 5.7 pIC50 >2000 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 5209-5213 [PMID:19631533]
ChEMBL Inhibition of PDE4B B 6.54 pIC50 290 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 5209-5213 [PMID:19631533]
phosphodiesterase 4C/Phosphodiesterase 4C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL291] [GtoPdb: 1302] [UniProtKB: Q08493]
ChEMBL Inhibition of PDE4C B 5.7 pIC50 >2000 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 5209-5213 [PMID:19631533]
phosphodiesterase 4D/Phosphodiesterase 4D in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL288] [GtoPdb: 1303] [UniProtKB: Q08499]
ChEMBL Inhibition of PDE4D B 5.92 pIC50 1210 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 5209-5213 [PMID:19631533]
phosphodiesterase 5A/Phosphodiesterase 5A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1827] [GtoPdb: 1304] [UniProtKB: O76074]
GtoPdb - - 10.3 pIC50 0.05 nM IC50 Bioorg Med Chem Lett (2009) 19: 5209-13 [PMID:19631533]
ChEMBL Inhibition of PDE5 B 10.3 pIC50 0.05 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 5209-5213 [PMID:19631533]
phosphodiesterase 6A/Phosphodiesterase 6A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3878] [GtoPdb: 1312] [UniProtKB: P16499]
ChEMBL Inhibition of PDE6 B 8.01 pIC50 9.8 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 5209-5213 [PMID:19631533]
GtoPdb - - 8.01 pIC50 9.8 nM IC50 Bioorg Med Chem Lett (2009) 19: 5209-13 [PMID:19631533]
phosphodiesterase 7A/Phosphodiesterase 7A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3012] [GtoPdb: 1305] [UniProtKB: Q13946]
ChEMBL Inhibition of PDE7A B 5.7 pIC50 >2000 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 5209-5213 [PMID:19631533]
phosphodiesterase 7B/Phosphodiesterase 7B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4716] [GtoPdb: 1306] [UniProtKB: Q9NP56]
ChEMBL Inhibition of PDE7B B 5.7 pIC50 >2000 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 5209-5213 [PMID:19631533]
phosphodiesterase 8A/Phosphodiesterase 8A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4640] [GtoPdb: 1307] [UniProtKB: O60658]
ChEMBL Inhibition of PDE8A B 5.7 pIC50 >2000 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 5209-5213 [PMID:19631533]
phosphodiesterase 8B/Phosphodiesterase 8B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4408] [GtoPdb: 1308] [UniProtKB: O95263]
ChEMBL Inhibition of PDE8B B 5.7 pIC50 >2000 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 5209-5213 [PMID:19631533]
phosphodiesterase 9A/Phosphodiesterase 9A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3535] [GtoPdb: 1309] [UniProtKB: O76083]
ChEMBL Inhibition of PDE9 B 5.7 pIC50 >2000 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 5209-5213 [PMID:19631533]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]