compound 53 [PMID: 19631533] [Ligand Id: 8811] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL567470 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| phosphodiesterase 11A/Phosphodiesterase 11A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2717] [GtoPdb: 1311] [UniProtKB: Q9HCR9] | ||||||||
| ChEMBL | Inhibition of PDE11 | B | 7.19 | pIC50 | 64.1 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533] |
| phosphodiesterase 1A/Phosphodiesterase 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3421] [GtoPdb: 1294] [UniProtKB: P54750] | ||||||||
| ChEMBL | Inhibition of PDE1A | B | 5.7 | pIC50 | >2000 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533] |
| phosphodiesterase 1B/Phosphodiesterase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4425] [GtoPdb: 1295] [UniProtKB: Q01064] | ||||||||
| ChEMBL | Inhibition of PDE1B | B | 5.7 | pIC50 | >2000 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533] |
| phosphodiesterase 1C/Phosphodiesterase 1C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4619] [GtoPdb: 1296] [UniProtKB: Q14123] | ||||||||
| ChEMBL | Inhibition of PDE1C | B | 5.7 | pIC50 | >2000 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533] |
| phosphodiesterase 2A/Phosphodiesterase 2A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2652] [GtoPdb: 1297] [UniProtKB: O00408] | ||||||||
| ChEMBL | Inhibition of PDE2 | B | 5.7 | pIC50 | >2000 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533] |
| phosphodiesterase 3A/Phosphodiesterase 3A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL241] [GtoPdb: 1298] [UniProtKB: Q14432] | ||||||||
| ChEMBL | Inhibition of PDE3A | B | 5.7 | pIC50 | >2000 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533] |
| phosphodiesterase 3B/Phosphodiesterase 3B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL290] [GtoPdb: 1299] [UniProtKB: Q13370] | ||||||||
| ChEMBL | Inhibition of PDE3B | B | 5.7 | pIC50 | >2000 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533] |
| phosphodiesterase 4A/Phosphodiesterase 4A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL254] [GtoPdb: 1300] [UniProtKB: P27815] | ||||||||
| ChEMBL | Inhibition of PDE4A | B | 5.7 | pIC50 | >2000 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533] |
| phosphodiesterase 4B/Phosphodiesterase 4B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL275] [GtoPdb: 1301] [UniProtKB: Q07343] | ||||||||
| ChEMBL | Inhibition of PDE4B | B | 5.7 | pIC50 | >2000 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533] |
| ChEMBL | Inhibition of PDE4B | B | 6.54 | pIC50 | 290 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533] |
| phosphodiesterase 4C/Phosphodiesterase 4C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL291] [GtoPdb: 1302] [UniProtKB: Q08493] | ||||||||
| ChEMBL | Inhibition of PDE4C | B | 5.7 | pIC50 | >2000 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533] |
| phosphodiesterase 4D/Phosphodiesterase 4D in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL288] [GtoPdb: 1303] [UniProtKB: Q08499] | ||||||||
| ChEMBL | Inhibition of PDE4D | B | 5.92 | pIC50 | 1210 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533] |
| phosphodiesterase 5A/Phosphodiesterase 5A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1827] [GtoPdb: 1304] [UniProtKB: O76074] | ||||||||
| GtoPdb | - | - | 10.3 | pIC50 | 0.05 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5209-13 [PMID:19631533] |
| ChEMBL | Inhibition of PDE5 | B | 10.3 | pIC50 | 0.05 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533] |
| phosphodiesterase 6A/Phosphodiesterase 6A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3878] [GtoPdb: 1312] [UniProtKB: P16499] | ||||||||
| ChEMBL | Inhibition of PDE6 | B | 8.01 | pIC50 | 9.8 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533] |
| GtoPdb | - | - | 8.01 | pIC50 | 9.8 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5209-13 [PMID:19631533] |
| phosphodiesterase 7A/Phosphodiesterase 7A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3012] [GtoPdb: 1305] [UniProtKB: Q13946] | ||||||||
| ChEMBL | Inhibition of PDE7A | B | 5.7 | pIC50 | >2000 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533] |
| phosphodiesterase 7B/Phosphodiesterase 7B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4716] [GtoPdb: 1306] [UniProtKB: Q9NP56] | ||||||||
| ChEMBL | Inhibition of PDE7B | B | 5.7 | pIC50 | >2000 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533] |
| phosphodiesterase 8A/Phosphodiesterase 8A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4640] [GtoPdb: 1307] [UniProtKB: O60658] | ||||||||
| ChEMBL | Inhibition of PDE8A | B | 5.7 | pIC50 | >2000 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533] |
| phosphodiesterase 8B/Phosphodiesterase 8B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4408] [GtoPdb: 1308] [UniProtKB: O95263] | ||||||||
| ChEMBL | Inhibition of PDE8B | B | 5.7 | pIC50 | >2000 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533] |
| phosphodiesterase 9A/Phosphodiesterase 9A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3535] [GtoPdb: 1309] [UniProtKB: O76083] | ||||||||
| ChEMBL | Inhibition of PDE9 | B | 5.7 | pIC50 | >2000 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
