compound 30 [PMID: 16455256] [Ligand Id: 8813] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL205742
  • Monocarboxylate transporter 1 in Human [ChEMBL: CHEMBL4360] [GtoPdb: 988] [UniProtKB: P53985]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Monocarboxylate transporter 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4360] [GtoPdb: 988] [UniProtKB: P53985]
ChEMBL Displacement of [3H]5-[(3-hydroxypropyl)thio]-3-methyl-1-[2-(methyl-t)propyl-2,3-t2]-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione from MCT1 in human Jurkat cell membranes B 7.51 pKi 30.9 nM Ki Nat Chem Biol (2005) 1: 371-376 [PMID:16370372]
ChEMBL Binding affinity to MCT1 by SPA B 8.32 pKi 4.8 nM Ki Bioorg Med Chem Lett (2006) 16: 2260-2265 [PMID:16455256]
ChEMBL Binding affinity to MCT1 B 8.32 pKi 4.8 nM Ki J Med Chem (2007) 50: 254-263 [PMID:17228867]
GtoPdb - - 8.32 pKi 4.8 nM Ki Bioorg Med Chem Lett (2006) 16: 2260-5 [PMID:16455256]
ChEMBL Displacement of [3H]5-[(3-hydroxypropyl)thio]-3-methyl-1-[2-(methyl-t)propyl-2,3-t2]-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione from human MCT1 expressed in INS1 cell membrane B 8.48 pKi 3.31 nM Ki Nat Chem Biol (2005) 1: 371-376 [PMID:16370372]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]