7ACC2 [Ligand Id: 8818] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2442509
  • Monocarboxylate transporter 4 in Human [ChEMBL: CHEMBL2073663] [GtoPdb: 989] [UniProtKB: O15427]
  • This target only has 0 pki data point
  • 0
1 CHEMBL2442509_lig_chart_1 Monocarboxylate transporter 4 Human
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  • Monocarboxylate transporter 2 in Human [GtoPdb: 990] [UniProtKB: O60669]
  • This target only has 0 pki data point
  • 0
2 CHEMBL2442509_lig_chart_2 Monocarboxylate transporter 2 Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Monocarboxylate transporter 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073663] [GtoPdb: 989] [UniProtKB: O15427]
ChEMBL Inhibition of MCT4-mediated [14C]-lactate uptake in human SiHa cells in lactate-containing medium assessed as remaining lactate concentration in culture medium after 24 hrs by liquid scintillation counting B 7.23 pIC50 59 nM IC50 Bioorg. Med. Chem. (2013) 21: 7107-7117 [PMID:24095010]
ChEMBL Inhibition of MCT4-mediated [14C]-lactate uptake in human SiHa cells in lactate-containing medium assessed as remaining lactate concentration in culture medium after 12 mins by liquid scintillation counting B 8 pIC50 10 nM IC50 Bioorg. Med. Chem. (2013) 21: 7107-7117 [PMID:24095010]
Monocarboxylate transporter 2 in Human [GtoPdb: 990] [UniProtKB: O60669]
GtoPdb - - 7.96 pIC50 11 nM IC50 Bioorg Med Chem (2013) 21: 7107-17 [PMID:24095010]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]