7ACC2 [Ligand Id: 8818] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2442509
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  • Monocarboxylate transporter 2 in Human [GtoPdb: 990] [UniProtKB: O60669]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Monocarboxylate transporter 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073663] [GtoPdb: 989] [UniProtKB: O15427]
ChEMBL Inhibition of MCT4-mediated [14C]-lactate uptake in human SiHa cells in lactate-containing medium assessed as remaining lactate concentration in culture medium after 24 hrs by liquid scintillation counting B 7.23 pIC50 59 nM IC50 Bioorg Med Chem (2013) 21: 7107-7117 [PMID:24095010]
ChEMBL Inhibition of MCT4-mediated [14C]-lactate uptake in human SiHa cells in lactate-containing medium assessed as remaining lactate concentration in culture medium after 12 mins by liquid scintillation counting B 8 pIC50 10 nM IC50 Bioorg Med Chem (2013) 21: 7107-7117 [PMID:24095010]
Monocarboxylate transporter 2 in Human [GtoPdb: 990] [UniProtKB: O60669]
GtoPdb - - 7.96 pIC50 11 nM IC50 Bioorg Med Chem (2013) 21: 7107-17 [PMID:24095010]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]