ChEMBL ligand: CHEMBL106820
NG,NG-Dimethylarginine dimethylaminohydrolase 1/N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 in Human [ChEMBL: CHEMBL6036] [GtoPdb: 1247] [UniProtKB: O94760] There should be some charts here, you may need to enable JavaScript!
Neuronal NOS/Nitric-oxide synthase, brain in Human [ChEMBL: CHEMBL3568] [GtoPdb: 1251] [UniProtKB: P29475] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
NG,NG-Dimethylarginine dimethylaminohydrolase 1/N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6036] [GtoPdb: 1247] [UniProtKB: O94760]
ChEMBL	Inhibition of human DDAH1 by plate-reader assay	B	5.7	pKi	2000	nM	Ki	Bioorg. Med. Chem. (2008) 16: 10205-10209 [PMID:19013076]
ChEMBL	Inhibition of 6xHis-tagged recombinant human DDAH1 expressed in Escherichia coli BL21 cells using NMMA as substrate measured after 30 mins by colder reagent based microplate reader assay	B	5.7	pKi	2000	nM	Ki	J Med Chem (2020) 63: 425-432 [PMID:31841335]
GtoPdb	-	-	5.7	pKi	2000	nM	Ki	Bioorg Med Chem (2008) 16: 10205-9 [PMID:19013076]
ChEMBL	Inhibition of human DDAH1 by plate-reader assay	B	4.89	pIC50	13000	nM	IC50	Bioorg. Med. Chem. (2008) 16: 10205-10209 [PMID:19013076]
Neuronal NOS/Nitric-oxide synthase, brain in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3568] [GtoPdb: 1251] [UniProtKB: P29475]
ChEMBL	Inhibition of nNOS assessed as conversion of L-[3H]arginine to L-[3H]citrulline	B	7	pKi	100	nM	Ki	Bioorg. Med. Chem. (2008) 16: 6193-6206 [PMID:18477512]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]