compound 8a [PMID: 23713581] [Ligand Id: 8856] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2396718 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Dual specificity protein phosphatase 15 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2396507] [UniProtKB: Q9H1R2] | ||||||||
| ChEMBL | Inhibition of recombinant VHX (unknown origin) using pNPP as substrate by spectrophotometric analysis | B | 5.54 | pIC50 | 2900 | nM | IC50 | J Med Chem (2013) 56: 4990-5008 [PMID:23713581] |
| Dual specificity protein phosphatase 23 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2396506] [UniProtKB: Q9BVJ7] | ||||||||
| ChEMBL | Inhibition of recombinant VHZ (unknown origin) using pNPP as substrate by spectrophotometric analysis | B | 5.47 | pIC50 | 3400 | nM | IC50 | J Med Chem (2013) 56: 4990-5008 [PMID:23713581] |
| Dual specificity protein phosphatase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2635] [UniProtKB: P51452] | ||||||||
| ChEMBL | Inhibition of recombinant VHR (unknown origin) using pNPP as substrate by spectrophotometric analysis | B | 5.23 | pIC50 | 5900 | nM | IC50 | J Med Chem (2013) 56: 4990-5008 [PMID:23713581] |
| protein tyrosine phosphatase non-receptor type 22/Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2889] [GtoPdb: 3084] [UniProtKB: Q9Y2R2] | ||||||||
| ChEMBL | Inhibition of N-terminal 6xHis-tagged LYP catalytic domain (1 to 303) (unknown origin) expressed in Escherichia coli BL21(DE3) using pNPP as substrate by spectrophotometric analysis | B | 6.77 | pIC50 | 171 | nM | IC50 | J Med Chem (2013) 56: 4990-5008 [PMID:23713581] |
| GtoPdb | - | - | 6.77 | pIC50 | 171 | nM | IC50 | J Med Chem (2013) 56: 4990-5008 [PMID:23713581] |
| RTP Type C/Leukocyte common antigen in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3243] [GtoPdb: 1852] [UniProtKB: P08575] | ||||||||
| ChEMBL | Inhibition of recombinant CD45 (unknown origin) using pNPP as substrate by spectrophotometric analysis | B | 5.49 | pIC50 | 3200 | nM | IC50 | J Med Chem (2013) 56: 4990-5008 [PMID:23713581] |
| Low molecular weight phosphotyrosine protein phosphatase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4903] [UniProtKB: P24666] | ||||||||
| ChEMBL | Inhibition of recombinant LMWPTP (unknown origin) using pNPP as substrate by spectrophotometric analysis | B | 6.47 | pIC50 | 340 | nM | IC50 | J Med Chem (2013) 56: 4990-5008 [PMID:23713581] |
| protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031] | ||||||||
| ChEMBL | Inhibition of recombinant PTP1B (unknown origin) using pNPP as substrate by spectrophotometric analysis | B | 5.77 | pIC50 | 1700 | nM | IC50 | J Med Chem (2013) 56: 4990-5008 [PMID:23713581] |
| Protein-tyrosine phosphatase 1C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3166] [UniProtKB: P29350] | ||||||||
| ChEMBL | Inhibition of recombinant SHP-1 (unknown origin) using pNPP as substrate by spectrophotometric analysis | B | 6.04 | pIC50 | 910 | nM | IC50 | J Med Chem (2013) 56: 4990-5008 [PMID:23713581] |
| Protein-tyrosine phosphatase 1E in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2976] [UniProtKB: Q12923] | ||||||||
| ChEMBL | Inhibition of recombinant FAP-1 (unknown origin) using pNPP as substrate by spectrophotometric analysis | B | 6.41 | pIC50 | 390 | nM | IC50 | J Med Chem (2013) 56: 4990-5008 [PMID:23713581] |
| protein tyrosine phosphatase non-receptor type 11/Protein-tyrosine phosphatase 2C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3864] [GtoPdb: 3203] [UniProtKB: Q06124] | ||||||||
| ChEMBL | Inhibition of recombinant SHP-2 (unknown origin) using pNPP as substrate by spectrophotometric analysis | B | 6.25 | pIC50 | 560 | nM | IC50 | J Med Chem (2013) 56: 4990-5008 [PMID:23713581] |
| Protein-tyrosine phosphatase G1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3236] [UniProtKB: Q05209] | ||||||||
| ChEMBL | Inhibition of recombinant PTP-PEST (unknown origin) using pNPP as substrate by spectrophotometric analysis | B | 6.1 | pIC50 | 800 | nM | IC50 | J Med Chem (2013) 56: 4990-5008 [PMID:23713581] |
| Protein-tyrosine phosphatase LC-PTP in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2219] [UniProtKB: P35236] | ||||||||
| ChEMBL | Inhibition of recombinant HEPTP (unknown origin) using pNPP as substrate by spectrophotometric analysis | B | 5.52 | pIC50 | 3000 | nM | IC50 | J Med Chem (2013) 56: 4990-5008 [PMID:23713581] |
| RTP Type B/Receptor-type tyrosine-protein phosphatase beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2706] [GtoPdb: 1851] [UniProtKB: P23467] | ||||||||
| ChEMBL | Inhibition of recombinant PTPbeta (unknown origin) using pNPP as substrate by spectrophotometric analysis | B | 6.33 | pIC50 | 470 | nM | IC50 | J Med Chem (2013) 56: 4990-5008 [PMID:23713581] |
| RTP Type E/Receptor-type tyrosine-protein phosphatase epsilon in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4850] [GtoPdb: 1854] [UniProtKB: P23469] | ||||||||
| ChEMBL | Inhibition of recombinant PTPepsilon (unknown origin) using pNPP as substrate by spectrophotometric analysis | B | 4.6 | pIC50 | >25000 | nM | IC50 | J Med Chem (2013) 56: 4990-5008 [PMID:23713581] |
| RTP Type G/Receptor-type tyrosine-protein phosphatase gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4905] [GtoPdb: 1856] [UniProtKB: P23470] | ||||||||
| ChEMBL | Inhibition of recombinant PTPgamma (unknown origin) using pNPP as substrate by spectrophotometric analysis | B | 5.4 | pIC50 | 4000 | nM | IC50 | J Med Chem (2013) 56: 4990-5008 [PMID:23713581] |
| RTP Type M/Receptor-type tyrosine-protein phosphatase mu in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4661] [GtoPdb: 1860] [UniProtKB: P28827] | ||||||||
| GtoPdb | - | - | 5.15 | pIC50 | 7000 | nM | IC50 | J Med Chem (2013) 56: 4990-5008 [PMID:23713581] |
| ChEMBL | Inhibition of recombinant PTPmu (unknown origin) using pNPP as substrate by spectrophotometric analysis | B | 5.15 | pIC50 | 7000 | nM | IC50 | J Med Chem (2013) 56: 4990-5008 [PMID:23713581] |
| protein tyrosine phosphatase non-receptor type 2/T-cell protein-tyrosine phosphatase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3807] [GtoPdb: 3255] [UniProtKB: P17706] | ||||||||
| ChEMBL | Inhibition of recombinant TCPTP (unknown origin) using pNPP as substrate by spectrophotometric analysis | B | 4.95 | pIC50 | 11300 | nM | IC50 | J Med Chem (2013) 56: 4990-5008 [PMID:23713581] |
| Tyrosine-protein phosphatase non-receptor type 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2396509] [UniProtKB: P26045] | ||||||||
| ChEMBL | Inhibition of recombinant PTPH1 (unknown origin) using pNPP as substrate by spectrophotometric analysis | B | 5.8 | pIC50 | 1600 | nM | IC50 | J Med Chem (2013) 56: 4990-5008 [PMID:23713581] |
| Tyrosine-protein phosphatase non-receptor type 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6117] [UniProtKB: P43378] | ||||||||
| ChEMBL | Inhibition of recombinant PTP-MEG2 (unknown origin) using pNPP as substrate by spectrophotometric analysis | B | 6.23 | pIC50 | 590 | nM | IC50 | J Med Chem (2013) 56: 4990-5008 [PMID:23713581] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
