ChEMBL ligand: CHEMBL1410015
ubiquitin specific peptidase 14/Ubiquitin carboxyl-terminal hydrolase 14 in Human [ChEMBL: CHEMBL1293295] [GtoPdb: 2429] [UniProtKB: P54578] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
ubiquitin specific peptidase 14/Ubiquitin carboxyl-terminal hydrolase 14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293295] [GtoPdb: 2429] [UniProtKB: P54578]
ChEMBL	Inhibition of full-length human USP14 using Ub-AMC substrate	B	4.91	pIC50	12300	nM	IC50	J Med Chem (2020) 63: 2731-2750 [PMID:31682427]
ChEMBL	Inhibition of human USP14 using Ub-PA as substrate assessed as deubiquitination level incubated for 1 hr by SDS-PAGE assay	B	4.91	pIC50	12250	nM	IC50	Eur J Med Chem (2020) 191: 112107-112107 [PMID:32092586]
GtoPdb	Measuring inhibition of Ub–AMC hydrolysis by proteasome-bound USP14	-	5.33	pIC50	4700	nM	IC50	Nature (2010) 467: 179-84 [PMID:20829789]
ChEMBL	Inhibition of human USP14	B	5.4	pIC50	4000	nM	IC50	Bioorg Med Chem Lett (2013) 23: 4328-4331 [PMID:23791076]
ChEMBL	Inhibition of USP14 (unknown origin) by Ub-AMC assay	B	5.4	pIC50	4000	nM	IC50	J Med Chem (2015) 58: 1581-1595 [PMID:25364867]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]