IU1 [Ligand Id: 8880] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1410015 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| ubiquitin specific peptidase 14/Ubiquitin carboxyl-terminal hydrolase 14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293295] [GtoPdb: 2429] [UniProtKB: P54578] | ||||||||
| ChEMBL | Inhibition of full-length human USP14 using Ub-AMC substrate | B | 4.91 | pIC50 | 12300 | nM | IC50 | J Med Chem (2020) 63: 2731-2750 [PMID:31682427] |
| GtoPdb | Measuring inhibition of Ub–AMC hydrolysis by proteasome-bound USP14 | - | 5.33 | pIC50 | 4700 | nM | IC50 | Nature (2010) 467: 179-84 [PMID:20829789] |
| ChEMBL | Inhibition of human USP14 | B | 5.4 | pIC50 | 4000 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 4328-4331 [PMID:23791076] |
| ChEMBL | Inhibition of USP14 (unknown origin) by Ub-AMC assay | B | 5.4 | pIC50 | 4000 | nM | IC50 | J Med Chem (2015) 58: 1581-1595 [PMID:25364867] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
